FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018556685> ?p ?o ?g. }

• W2018556685 endingPage "137" @default.
• W2018556685 startingPage "132" @default.
• W2018556685 abstract "• Objective To detect aneuploidy of chromosomes 13, 18,21, X, and Y with use of new, directly labeled, multicolored, commercially available DNA probes from interphase cells of amniotic fluid (AF). • Material and Methods The hybridization sites of the five probes were validated by metaphase analysis. The fluorescence in situ hybridization (FISH) normal range was determined from a series of normal AF specimens and tested on a series of normal and abnormal specimens. • Results The hybridization efficiencies of the five probes were 100%. The mean AF interphase disomic signal patterns for chromosomes 13, 18, 21, XX, and XY were 95.9%, 89.1%, 94.3%, 94.7%, and 98.7%, respectively. Of a total of 508 cases analyzed, 211 were aneuploid. All cases were correctly identified and no false results occurred (in comparison with karyotypic analysis), although maternal cell contamination was relatively common. • Conclusion Clinical screening for aneuploidy of chromosomes 13,18,21, X, and Y from interphase AF cells is possible with use of these probes and FISH. Cases of maternal cell contamination and mosaicism necessitate cautious interpretation. The FISH procedure is recommended for screening of common aneuploidies, followed by a complete chromosome analysis to detect anomalies. To detect aneuploidy of chromosomes 13, 18,21, X, and Y with use of new, directly labeled, multicolored, commercially available DNA probes from interphase cells of amniotic fluid (AF). The hybridization sites of the five probes were validated by metaphase analysis. The fluorescence in situ hybridization (FISH) normal range was determined from a series of normal AF specimens and tested on a series of normal and abnormal specimens. The hybridization efficiencies of the five probes were 100%. The mean AF interphase disomic signal patterns for chromosomes 13, 18, 21, XX, and XY were 95.9%, 89.1%, 94.3%, 94.7%, and 98.7%, respectively. Of a total of 508 cases analyzed, 211 were aneuploid. All cases were correctly identified and no false results occurred (in comparison with karyotypic analysis), although maternal cell contamination was relatively common. Clinical screening for aneuploidy of chromosomes 13,18,21, X, and Y from interphase AF cells is possible with use of these probes and FISH. Cases of maternal cell contamination and mosaicism necessitate cautious interpretation. The FISH procedure is recommended for screening of common aneuploidies, followed by a complete chromosome analysis to detect anomalies." @default.
• W2018556685 created "2016-06-24" @default.
• W2018556685 creator A5007612166 @default.
• W2018556685 creator A5013059066 @default.
• W2018556685 creator A5035605122 @default.
• W2018556685 creator A5080200072 @default.
• W2018556685 date "1998-02-01" @default.
• W2018556685 modified "2023-09-22" @default.
• W2018556685 title "Prenatal Detection of Aneuploidy by Directly Labeled Multicolored Probes and Interphase Fluorescence In Situ Hybridization" @default.
• W2018556685 cites W1964572644 @default.
• W2018556685 cites W1992284406 @default.
• W2018556685 cites W2004955435 @default.
• W2018556685 cites W2006027022 @default.
• W2018556685 cites W2016394543 @default.
• W2018556685 cites W2044551972 @default.
• W2018556685 cites W2084281720 @default.
• W2018556685 cites W2126663233 @default.
• W2018556685 cites W2135175754 @default.
• W2018556685 doi "https://doi.org/10.1016/s0025-6196(11)63644-6" @default.
• W2018556685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472995" @default.
• W2018556685 hasPublicationYear "1998" @default.
• W2018556685 type Work @default.
• W2018556685 sameAs 2018556685 @default.
• W2018556685 citedByCount "35" @default.
• W2018556685 countsByYear W20185566852012 @default.
• W2018556685 countsByYear W20185566852014 @default.
• W2018556685 countsByYear W20185566852015 @default.
• W2018556685 crossrefType "journal-article" @default.
• W2018556685 hasAuthorship W2018556685A5007612166 @default.
• W2018556685 hasAuthorship W2018556685A5013059066 @default.
• W2018556685 hasAuthorship W2018556685A5035605122 @default.
• W2018556685 hasAuthorship W2018556685A5080200072 @default.
• W2018556685 hasConcept C104317684 @default.
• W2018556685 hasConcept C130197536 @default.
• W2018556685 hasConcept C142724271 @default.
• W2018556685 hasConcept C150194340 @default.
• W2018556685 hasConcept C153911025 @default.
• W2018556685 hasConcept C172680121 @default.
• W2018556685 hasConcept C2777542201 @default.
• W2018556685 hasConcept C2778194526 @default.
• W2018556685 hasConcept C2779234561 @default.
• W2018556685 hasConcept C2779672484 @default.
• W2018556685 hasConcept C29452124 @default.
• W2018556685 hasConcept C30481170 @default.
• W2018556685 hasConcept C53226629 @default.
• W2018556685 hasConcept C54355233 @default.
• W2018556685 hasConcept C552990157 @default.
• W2018556685 hasConcept C70278784 @default.
• W2018556685 hasConcept C71924100 @default.
• W2018556685 hasConcept C81439078 @default.
• W2018556685 hasConcept C86803240 @default.
• W2018556685 hasConceptScore W2018556685C104317684 @default.
• W2018556685 hasConceptScore W2018556685C130197536 @default.
• W2018556685 hasConceptScore W2018556685C142724271 @default.
• W2018556685 hasConceptScore W2018556685C150194340 @default.
• W2018556685 hasConceptScore W2018556685C153911025 @default.
• W2018556685 hasConceptScore W2018556685C172680121 @default.
• W2018556685 hasConceptScore W2018556685C2777542201 @default.
• W2018556685 hasConceptScore W2018556685C2778194526 @default.
• W2018556685 hasConceptScore W2018556685C2779234561 @default.
• W2018556685 hasConceptScore W2018556685C2779672484 @default.
• W2018556685 hasConceptScore W2018556685C29452124 @default.
• W2018556685 hasConceptScore W2018556685C30481170 @default.
• W2018556685 hasConceptScore W2018556685C53226629 @default.
• W2018556685 hasConceptScore W2018556685C54355233 @default.
• W2018556685 hasConceptScore W2018556685C552990157 @default.
• W2018556685 hasConceptScore W2018556685C70278784 @default.
• W2018556685 hasConceptScore W2018556685C71924100 @default.
• W2018556685 hasConceptScore W2018556685C81439078 @default.
• W2018556685 hasConceptScore W2018556685C86803240 @default.
• W2018556685 hasIssue "2" @default.
• W2018556685 hasLocation W20185566851 @default.
• W2018556685 hasLocation W20185566852 @default.
• W2018556685 hasOpenAccess W2018556685 @default.
• W2018556685 hasPrimaryLocation W20185566851 @default.
• W2018556685 hasRelatedWork W1968800321 @default.
• W2018556685 hasRelatedWork W2004955435 @default.
• W2018556685 hasRelatedWork W2018556685 @default.
• W2018556685 hasRelatedWork W2040635823 @default.
• W2018556685 hasRelatedWork W2053615478 @default.
• W2018556685 hasRelatedWork W2116302199 @default.
• W2018556685 hasRelatedWork W2274152414 @default.
• W2018556685 hasRelatedWork W2397564815 @default.
• W2018556685 hasRelatedWork W2414367553 @default.
• W2018556685 hasRelatedWork W2470265485 @default.
• W2018556685 hasVolume "73" @default.
• W2018556685 isParatext "false" @default.
• W2018556685 isRetracted "false" @default.
• W2018556685 magId "2018556685" @default.
• W2018556685 workType "article" @default.