Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018558103> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2018558103 endingPage "698" @default.
- W2018558103 startingPage "S" @default.
- W2018558103 abstract "[Background & Aims]The granulocytapheresis (GCAP) for ulcerative colitis (UC) has been developed in Japan. GCAP is a non-pharmacological therapy thereby does not have severe adverse effect. The mechanism of GCAP is expected to reduce inflammatory cytokines and the production of L-selectin by absorbing selected active granulocytes. Weakness of GCAP is the difficulty of the anticipation of treatment effect in early treatment stage. In this study, we focused on adhesion molecules which are thought to be associated with the pathophysiology of UC. We examined 5 SNPs in 3 adhesion molecule genes. [Methods] Twenty eight UC patients (M12, F16, averaged age 37.9y.o.) who received GCAP in past 5 years were examined. These patients were 21 pancolitis, 5 left sided colitis and 2 proctitis. DNA was extracted from all patients by colonic biopsy or blood sample and examined about the polymorphisms by PCR-RFLP. Genes and polymorphisms were L-selectin -642C>T and 725C>T, PECAM-1 codon125 V>L, E-selectin 98G>T in exon2 and S128R in exon4. The differences of the clinical activity index (CAI) scores of preand post-treatment of each 1 course (5 times of GCAP performed) or 2 course (10times of GCAP performed) were used for the evaluation of UC activity. Statistical analysis was done by Mann-Whitney U test. [Results] L-selectin-642C>T C carrier tended to be contributed to better treatment results after 2 course. L-selectin 725C>T polymorphism was not associated with treatment effect. PECAM-1 codon125 V>L, L/L or L/V was significantly associated with better treatment effect within 1 course treatment than V/V (p T and S128R polymorphisms showed no effect about GCAP treatment. [Conclusions] In this study, a significant effect of polymorphisms in PECAM-1 was found. Future study will be needed to confirm this result in next step." @default.
- W2018558103 created "2016-06-24" @default.
- W2018558103 creator A5023712329 @default.
- W2018558103 creator A5043240541 @default.
- W2018558103 creator A5045596987 @default.
- W2018558103 creator A5050935984 @default.
- W2018558103 creator A5079534102 @default.
- W2018558103 date "2010-05-01" @default.
- W2018558103 modified "2023-09-26" @default.
- W2018558103 title "W1316 Genetic Polymorphisms of Adhesion Molecules and the Effect of Granulocytapheresis Treatment for Ulcerative Colitis" @default.
- W2018558103 doi "https://doi.org/10.1016/s0016-5085(10)63207-6" @default.
- W2018558103 hasPublicationYear "2010" @default.
- W2018558103 type Work @default.
- W2018558103 sameAs 2018558103 @default.
- W2018558103 citedByCount "0" @default.
- W2018558103 crossrefType "journal-article" @default.
- W2018558103 hasAuthorship W2018558103A5023712329 @default.
- W2018558103 hasAuthorship W2018558103A5043240541 @default.
- W2018558103 hasAuthorship W2018558103A5045596987 @default.
- W2018558103 hasAuthorship W2018558103A5050935984 @default.
- W2018558103 hasAuthorship W2018558103A5079534102 @default.
- W2018558103 hasConcept C126322002 @default.
- W2018558103 hasConcept C16224149 @default.
- W2018558103 hasConcept C178790620 @default.
- W2018558103 hasConcept C185592680 @default.
- W2018558103 hasConcept C2779134260 @default.
- W2018558103 hasConcept C2780479503 @default.
- W2018558103 hasConcept C54355233 @default.
- W2018558103 hasConcept C71924100 @default.
- W2018558103 hasConcept C84416704 @default.
- W2018558103 hasConcept C86803240 @default.
- W2018558103 hasConceptScore W2018558103C126322002 @default.
- W2018558103 hasConceptScore W2018558103C16224149 @default.
- W2018558103 hasConceptScore W2018558103C178790620 @default.
- W2018558103 hasConceptScore W2018558103C185592680 @default.
- W2018558103 hasConceptScore W2018558103C2779134260 @default.
- W2018558103 hasConceptScore W2018558103C2780479503 @default.
- W2018558103 hasConceptScore W2018558103C54355233 @default.
- W2018558103 hasConceptScore W2018558103C71924100 @default.
- W2018558103 hasConceptScore W2018558103C84416704 @default.
- W2018558103 hasConceptScore W2018558103C86803240 @default.
- W2018558103 hasIssue "5" @default.
- W2018558103 hasLocation W20185581031 @default.
- W2018558103 hasOpenAccess W2018558103 @default.
- W2018558103 hasPrimaryLocation W20185581031 @default.
- W2018558103 hasRelatedWork W181348724 @default.
- W2018558103 hasRelatedWork W2025048290 @default.
- W2018558103 hasRelatedWork W2086156447 @default.
- W2018558103 hasRelatedWork W2375240245 @default.
- W2018558103 hasRelatedWork W2464962541 @default.
- W2018558103 hasRelatedWork W2475104063 @default.
- W2018558103 hasRelatedWork W2765379856 @default.
- W2018558103 hasRelatedWork W2896381073 @default.
- W2018558103 hasRelatedWork W4210249856 @default.
- W2018558103 hasRelatedWork W4322722440 @default.
- W2018558103 hasVolume "138" @default.
- W2018558103 isParatext "false" @default.
- W2018558103 isRetracted "false" @default.
- W2018558103 magId "2018558103" @default.
- W2018558103 workType "article" @default.