Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018558719> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2018558719 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCCis-diamminedichloroplatinum (II) (CDDP) is a platinum based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas, lymphomas, and germ cell tumors. There are two major concerns of cisplatin based chemotherapy: first is relapse of cancer in majority of pateints with cisplatin resistant disease and second is cisplatin associated nephrotoxicity (kidney damage). In the present study, we have demonstrated that cisplatin can be complexed using a carboxylato bond with poly-isobutylene-maleic acid, derivatized with a polyethylene glycol moiety. We found that at unique cisplatin to polymer ratio, this conjugate self-assembles into nanoparticles, and exhibits enhanced therapeutic efficacy without any nephrotoxicity as compared with cisplatin in murine lewis lung carcinoma model. The PIMA-PEG-CDDP conjugate inhibited proliferation and induced apoptosis in Lewis lung carcinoma and 4T1 breast cancer cells in vitro. The nanoparticles were taken up by cancer cells through endocytosis within 6 hours and retained in subcellular compartment over 24 hours in 4T1 breast cancer cells. Furthermore, in an in vivo 4T1 breast cancer model, PIMA-PEG-CDDP nanoparticles reduce tumor growth drastically with no side effects, thus increasing the survival rate of the mice as compared to free cisplatin treated mice. Thus our studies showed that pegylated-PIMA-CDDP can be harnessed for lung and breast cancer chemotherapy with increased therapeutic index compared with cisplatin.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3520." @default.
- W2018558719 created "2016-06-24" @default.
- W2018558719 creator A5010475526 @default.
- W2018558719 creator A5036417614 @default.
- W2018558719 creator A5040718895 @default.
- W2018558719 creator A5051647183 @default.
- W2018558719 date "2010-04-15" @default.
- W2018558719 modified "2023-09-25" @default.
- W2018558719 title "Abstract 3520: Pegylated nanoplatinates: A novel re-engineered cisplatin for cancer chemotherapy" @default.
- W2018558719 doi "https://doi.org/10.1158/1538-7445.am10-3520" @default.
- W2018558719 hasPublicationYear "2010" @default.
- W2018558719 type Work @default.
- W2018558719 sameAs 2018558719 @default.
- W2018558719 citedByCount "0" @default.
- W2018558719 crossrefType "proceedings-article" @default.
- W2018558719 hasAuthorship W2018558719A5010475526 @default.
- W2018558719 hasAuthorship W2018558719A5036417614 @default.
- W2018558719 hasAuthorship W2018558719A5040718895 @default.
- W2018558719 hasAuthorship W2018558719A5051647183 @default.
- W2018558719 hasConcept C121608353 @default.
- W2018558719 hasConcept C126189478 @default.
- W2018558719 hasConcept C126322002 @default.
- W2018558719 hasConcept C143998085 @default.
- W2018558719 hasConcept C150903083 @default.
- W2018558719 hasConcept C207001950 @default.
- W2018558719 hasConcept C2776256026 @default.
- W2018558719 hasConcept C2776694085 @default.
- W2018558719 hasConcept C2778239845 @default.
- W2018558719 hasConcept C29730261 @default.
- W2018558719 hasConcept C502942594 @default.
- W2018558719 hasConcept C530470458 @default.
- W2018558719 hasConcept C71924100 @default.
- W2018558719 hasConcept C86803240 @default.
- W2018558719 hasConcept C98274493 @default.
- W2018558719 hasConceptScore W2018558719C121608353 @default.
- W2018558719 hasConceptScore W2018558719C126189478 @default.
- W2018558719 hasConceptScore W2018558719C126322002 @default.
- W2018558719 hasConceptScore W2018558719C143998085 @default.
- W2018558719 hasConceptScore W2018558719C150903083 @default.
- W2018558719 hasConceptScore W2018558719C207001950 @default.
- W2018558719 hasConceptScore W2018558719C2776256026 @default.
- W2018558719 hasConceptScore W2018558719C2776694085 @default.
- W2018558719 hasConceptScore W2018558719C2778239845 @default.
- W2018558719 hasConceptScore W2018558719C29730261 @default.
- W2018558719 hasConceptScore W2018558719C502942594 @default.
- W2018558719 hasConceptScore W2018558719C530470458 @default.
- W2018558719 hasConceptScore W2018558719C71924100 @default.
- W2018558719 hasConceptScore W2018558719C86803240 @default.
- W2018558719 hasConceptScore W2018558719C98274493 @default.
- W2018558719 hasLocation W20185587191 @default.
- W2018558719 hasOpenAccess W2018558719 @default.
- W2018558719 hasPrimaryLocation W20185587191 @default.
- W2018558719 hasRelatedWork W1487005072 @default.
- W2018558719 hasRelatedWork W1497490920 @default.
- W2018558719 hasRelatedWork W1976611041 @default.
- W2018558719 hasRelatedWork W1985145638 @default.
- W2018558719 hasRelatedWork W1990612735 @default.
- W2018558719 hasRelatedWork W2029891359 @default.
- W2018558719 hasRelatedWork W2045192228 @default.
- W2018558719 hasRelatedWork W2063685408 @default.
- W2018558719 hasRelatedWork W2074072718 @default.
- W2018558719 hasRelatedWork W2076485964 @default.
- W2018558719 hasRelatedWork W2087032612 @default.
- W2018558719 hasRelatedWork W2117571331 @default.
- W2018558719 hasRelatedWork W2549034843 @default.
- W2018558719 hasRelatedWork W2559907794 @default.
- W2018558719 hasRelatedWork W2772171402 @default.
- W2018558719 hasRelatedWork W2810125342 @default.
- W2018558719 hasRelatedWork W2956001841 @default.
- W2018558719 hasRelatedWork W2964913676 @default.
- W2018558719 hasRelatedWork W3115953999 @default.
- W2018558719 hasRelatedWork W6349928 @default.
- W2018558719 isParatext "false" @default.
- W2018558719 isRetracted "false" @default.
- W2018558719 magId "2018558719" @default.
- W2018558719 workType "article" @default.