FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018559670> ?p ?o ?g. }

• W2018559670 endingPage "1292" @default.
• W2018559670 startingPage "1283" @default.
• W2018559670 abstract "A family of injectable, biodegradable, and thermosensitive copolymers based on N-isopropylacrylamide, acrylic acid, N-acryloxysuccinimide, and a macromer polylactide-hydroxyethyl methacrylate were synthesized by free radical polymerization. Copolymers were injectable at or below room temperature and formed robust hydrogels at 37 degrees C. The effects of monomer ratio, polylactide length, and AAc content on the chemical and physical properties of the hydrogel were investigated. Copolymers exhibited lower critical solution temperatures (LCSTs) from 18 to 26 degrees C. After complete hydrolysis, hydrogels were soluble in phosphate buffered saline at 37 degrees C with LCSTs above 40.8 degrees C. Incorporation of type I collagen at varying mass fractions by covalent reaction with the copolymer backbone slightly increased LCSTs. Water content was 32-80% without collagen and increased to 230% with collagen at 37 degrees C. Hydrogels were highly flexible and relatively strong at 37 degrees C, with tensile strengths from 0.3 to 1.1 MPa and elongations at break from 344 to 1841% depending on NIPAAm/HEMAPLA ratio, AAc content, and polylactide length. Increasing the collagen content decreased both elongation at break and tensile strength. Hydrogel weight loss at 37 degrees C was 85-96% over 21 days and varied with polylactide content. Hydrogel weight loss at 37 degrees C was 85-96% over 21 days and varied with polylactide content. Degradation products were shown to be noncytotoxic. Cell adhesion on the hydrogels was 30% of that for tissue culture polystyrene but increased to statistically approximate this control surface after collagen incorporation. These newly described thermoresponsive copolymers demonstrated attractive properties to serve as cell or pharmaceutical delivery vehicles for a variety of tissue engineering applications." @default.
• W2018559670 created "2016-06-24" @default.
• W2018559670 creator A5007830637 @default.
• W2018559670 creator A5045386624 @default.
• W2018559670 creator A5045877983 @default.
• W2018559670 creator A5090064010 @default.
• W2018559670 date "2008-03-07" @default.
• W2018559670 modified "2023-09-25" @default.
• W2018559670 title "Protein-Reactive, Thermoresponsive Copolymers with High Flexibility and Biodegradability" @default.
• W2018559670 cites W131033098 @default.
• W2018559670 cites W1971413820 @default.
• W2018559670 cites W1977492547 @default.
• W2018559670 cites W1988186759 @default.
• W2018559670 cites W1991986285 @default.
• W2018559670 cites W2005048924 @default.
• W2018559670 cites W2005150737 @default.
• W2018559670 cites W2009328092 @default.
• W2018559670 cites W2015663302 @default.
• W2018559670 cites W2021625203 @default.
• W2018559670 cites W2025328826 @default.
• W2018559670 cites W2058509094 @default.
• W2018559670 cites W2058864000 @default.
• W2018559670 cites W2065968002 @default.
• W2018559670 cites W2068531535 @default.
• W2018559670 cites W2072386662 @default.
• W2018559670 cites W2072639108 @default.
• W2018559670 cites W2074923625 @default.
• W2018559670 cites W2081030247 @default.
• W2018559670 cites W2084610464 @default.
• W2018559670 cites W2088003749 @default.
• W2018559670 cites W2089858022 @default.
• W2018559670 cites W2093215475 @default.
• W2018559670 cites W2120949673 @default.
• W2018559670 cites W2154693046 @default.
• W2018559670 doi "https://doi.org/10.1021/bm701265j" @default.
• W2018559670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860788" @default.
• W2018559670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18324775" @default.
• W2018559670 hasPublicationYear "2008" @default.
• W2018559670 type Work @default.
• W2018559670 sameAs 2018559670 @default.
• W2018559670 citedByCount "85" @default.
• W2018559670 countsByYear W20185596702012 @default.
• W2018559670 countsByYear W20185596702013 @default.
• W2018559670 countsByYear W20185596702014 @default.
• W2018559670 countsByYear W20185596702015 @default.
• W2018559670 countsByYear W20185596702016 @default.
• W2018559670 countsByYear W20185596702017 @default.
• W2018559670 countsByYear W20185596702018 @default.
• W2018559670 countsByYear W20185596702019 @default.
• W2018559670 countsByYear W20185596702020 @default.
• W2018559670 countsByYear W20185596702021 @default.
• W2018559670 countsByYear W20185596702022 @default.
• W2018559670 countsByYear W20185596702023 @default.
• W2018559670 crossrefType "journal-article" @default.
• W2018559670 hasAuthorship W2018559670A5007830637 @default.
• W2018559670 hasAuthorship W2018559670A5045386624 @default.
• W2018559670 hasAuthorship W2018559670A5045877983 @default.
• W2018559670 hasAuthorship W2018559670A5090064010 @default.
• W2018559670 hasBestOaLocation W20185596702 @default.
• W2018559670 hasConcept C108586683 @default.
• W2018559670 hasConcept C111998727 @default.
• W2018559670 hasConcept C112950240 @default.
• W2018559670 hasConcept C127413603 @default.
• W2018559670 hasConcept C132050475 @default.
• W2018559670 hasConcept C136520611 @default.
• W2018559670 hasConcept C15920480 @default.
• W2018559670 hasConcept C159985019 @default.
• W2018559670 hasConcept C166940927 @default.
• W2018559670 hasConcept C185592680 @default.
• W2018559670 hasConcept C188027245 @default.
• W2018559670 hasConcept C188109995 @default.
• W2018559670 hasConcept C192562407 @default.
• W2018559670 hasConcept C2780503075 @default.
• W2018559670 hasConcept C42360764 @default.
• W2018559670 hasConcept C44228677 @default.
• W2018559670 hasConcept C521977710 @default.
• W2018559670 hasConceptScore W2018559670C108586683 @default.
• W2018559670 hasConceptScore W2018559670C111998727 @default.
• W2018559670 hasConceptScore W2018559670C112950240 @default.
• W2018559670 hasConceptScore W2018559670C127413603 @default.
• W2018559670 hasConceptScore W2018559670C132050475 @default.
• W2018559670 hasConceptScore W2018559670C136520611 @default.
• W2018559670 hasConceptScore W2018559670C15920480 @default.
• W2018559670 hasConceptScore W2018559670C159985019 @default.
• W2018559670 hasConceptScore W2018559670C166940927 @default.
• W2018559670 hasConceptScore W2018559670C185592680 @default.
• W2018559670 hasConceptScore W2018559670C188027245 @default.
• W2018559670 hasConceptScore W2018559670C188109995 @default.
• W2018559670 hasConceptScore W2018559670C192562407 @default.
• W2018559670 hasConceptScore W2018559670C2780503075 @default.
• W2018559670 hasConceptScore W2018559670C42360764 @default.
• W2018559670 hasConceptScore W2018559670C44228677 @default.
• W2018559670 hasConceptScore W2018559670C521977710 @default.
• W2018559670 hasIssue "4" @default.
• W2018559670 hasLocation W20185596701 @default.
• W2018559670 hasLocation W20185596702 @default.
• W2018559670 hasLocation W20185596703 @default.
• W2018559670 hasLocation W20185596704 @default.

• next