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• W2018559734 abstract "Urinary excretion of the post-translationally modified amino-acid 3-methylhistidine, derived from the contractile proteins actin and myosin, was measured in patients with conditions associated with nitrogen loss. The ratio of 3-methylhistidine:creatinine excretion, a measure of the fractional catabolic rate of myofibrillar protein was increased in severe injury, thyrotoxicosis, neoplastic disease, prednisolone administration, and sometimes Duchenne muscular dystrophy. In myxoedema, osteomalacia, and hypothermia the ratio was decreased; and starvation, elective operations, and rheumatoid arthritis had little effect. Provided that the diet is meat free, measurement of urinary 3-methylhistidine may provide useful information on the cause of protein loss." @default.
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• W2018559734 date "1981-01-31" @default.
• W2018559734 modified "2023-10-18" @default.
• W2018559734 title "Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown." @default.
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• W2018559734 doi "https://doi.org/10.1136/bmj.282.6261.351" @default.
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