Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018561645> ?p ?o ?g. }
- W2018561645 endingPage "182" @default.
- W2018561645 startingPage "176" @default.
- W2018561645 abstract "To examine regional differences of synaptic transmission, the effects of midazolam were observed on inhibitory postsynaptic currents (IPSCs) in CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. Midazolam is one of the most popular benzodiazepines. The monosynaptic IPSCs in the CA1-PCs and DG-GCs were evoked by electrical stimulation of GABAergic interneurons and recorded by whole cell patch-clamp techniques. The effects of specific concentrations of midazolam (0.3, 1, 10 and 75 μM) on the IPSCs in CA1-PCs and DG-GCs were examined at particular membrane potentials (20 mV steps, from −120 to +40 mV). In all midazolam concentrations tested, the conductance of the IPSCs was significantly larger than that in control and was increased by increasing the concentration of midazolam in CA1-PCs (normalized conductance, 0.3 μM, 121%; 1 μM, 125%; 10 μM, 147%; 75 μM, 147%). However, midazolam did not significantly change the conductance of the IPSCs in DG-GCs (normalized conductance, 0.3 μM, 92%; 1 μM, 92%; 10 μM, 91%; 75 μM, 115%). The normalized conductance was significantly different between the CA1-PCs and DG-GCs in 1 and 10 μM midazolam. The results strongly suggest that the differential effects of midazolam on IPSCs in CA1-PCs and DG-GCs could be, at least in part, due to the different sensitivity to midazolam of the GABAA receptor subtypes." @default.
- W2018561645 created "2016-06-24" @default.
- W2018561645 creator A5012475189 @default.
- W2018561645 creator A5020811322 @default.
- W2018561645 creator A5049147459 @default.
- W2018561645 creator A5087085530 @default.
- W2018561645 date "2004-04-01" @default.
- W2018561645 modified "2023-10-16" @default.
- W2018561645 title "Differential effects of midazolam on inhibitory postsynaptic currents in CA1 pyramidal cells and dentate gyrus granule cells of rat hippocampal slices" @default.
- W2018561645 cites W1524203275 @default.
- W2018561645 cites W1597869519 @default.
- W2018561645 cites W182099624 @default.
- W2018561645 cites W1971273652 @default.
- W2018561645 cites W1972589569 @default.
- W2018561645 cites W1974914532 @default.
- W2018561645 cites W1976589926 @default.
- W2018561645 cites W1977052342 @default.
- W2018561645 cites W1986905703 @default.
- W2018561645 cites W1988930626 @default.
- W2018561645 cites W1997212266 @default.
- W2018561645 cites W2009952187 @default.
- W2018561645 cites W2010374860 @default.
- W2018561645 cites W2011296924 @default.
- W2018561645 cites W2018345842 @default.
- W2018561645 cites W2022378061 @default.
- W2018561645 cites W2022381402 @default.
- W2018561645 cites W2024328209 @default.
- W2018561645 cites W2025810192 @default.
- W2018561645 cites W2038996858 @default.
- W2018561645 cites W2039947173 @default.
- W2018561645 cites W2047243202 @default.
- W2018561645 cites W2048602049 @default.
- W2018561645 cites W2053445039 @default.
- W2018561645 cites W2057298285 @default.
- W2018561645 cites W2060589548 @default.
- W2018561645 cites W2061042379 @default.
- W2018561645 cites W2071487865 @default.
- W2018561645 cites W2071526018 @default.
- W2018561645 cites W2082050133 @default.
- W2018561645 cites W2084566100 @default.
- W2018561645 cites W2106001183 @default.
- W2018561645 cites W2272879872 @default.
- W2018561645 cites W2299687596 @default.
- W2018561645 cites W29188351 @default.
- W2018561645 doi "https://doi.org/10.1016/j.brainres.2004.01.015" @default.
- W2018561645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15019577" @default.
- W2018561645 hasPublicationYear "2004" @default.
- W2018561645 type Work @default.
- W2018561645 sameAs 2018561645 @default.
- W2018561645 citedByCount "16" @default.
- W2018561645 countsByYear W20185616452012 @default.
- W2018561645 countsByYear W20185616452015 @default.
- W2018561645 countsByYear W20185616452016 @default.
- W2018561645 countsByYear W20185616452019 @default.
- W2018561645 countsByYear W20185616452020 @default.
- W2018561645 countsByYear W20185616452021 @default.
- W2018561645 crossrefType "journal-article" @default.
- W2018561645 hasAuthorship W2018561645A5012475189 @default.
- W2018561645 hasAuthorship W2018561645A5020811322 @default.
- W2018561645 hasAuthorship W2018561645A5049147459 @default.
- W2018561645 hasAuthorship W2018561645A5087085530 @default.
- W2018561645 hasConcept C112592302 @default.
- W2018561645 hasConcept C12554922 @default.
- W2018561645 hasConcept C147944092 @default.
- W2018561645 hasConcept C148762608 @default.
- W2018561645 hasConcept C168258287 @default.
- W2018561645 hasConcept C169760540 @default.
- W2018561645 hasConcept C170493617 @default.
- W2018561645 hasConcept C17077164 @default.
- W2018561645 hasConcept C185263204 @default.
- W2018561645 hasConcept C185592680 @default.
- W2018561645 hasConcept C197341189 @default.
- W2018561645 hasConcept C2776464000 @default.
- W2018561645 hasConcept C2776814716 @default.
- W2018561645 hasConcept C2778000748 @default.
- W2018561645 hasConcept C2910581834 @default.
- W2018561645 hasConcept C55493867 @default.
- W2018561645 hasConcept C86803240 @default.
- W2018561645 hasConcept C98274493 @default.
- W2018561645 hasConceptScore W2018561645C112592302 @default.
- W2018561645 hasConceptScore W2018561645C12554922 @default.
- W2018561645 hasConceptScore W2018561645C147944092 @default.
- W2018561645 hasConceptScore W2018561645C148762608 @default.
- W2018561645 hasConceptScore W2018561645C168258287 @default.
- W2018561645 hasConceptScore W2018561645C169760540 @default.
- W2018561645 hasConceptScore W2018561645C170493617 @default.
- W2018561645 hasConceptScore W2018561645C17077164 @default.
- W2018561645 hasConceptScore W2018561645C185263204 @default.
- W2018561645 hasConceptScore W2018561645C185592680 @default.
- W2018561645 hasConceptScore W2018561645C197341189 @default.
- W2018561645 hasConceptScore W2018561645C2776464000 @default.
- W2018561645 hasConceptScore W2018561645C2776814716 @default.
- W2018561645 hasConceptScore W2018561645C2778000748 @default.
- W2018561645 hasConceptScore W2018561645C2910581834 @default.
- W2018561645 hasConceptScore W2018561645C55493867 @default.
- W2018561645 hasConceptScore W2018561645C86803240 @default.
- W2018561645 hasConceptScore W2018561645C98274493 @default.
- W2018561645 hasFunder F4320320912 @default.