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• W2018561922 abstract "Understanding the metabolic and structural changes during the course of Alzheimer's disease (AD) is a task of major relevance since it would allow identifying clinical biomarkers suitable for an early diagnosis. In the frame of IMI-PharmaCog European Consortium, we performed a longitudinal MRI and 1 H MRS analysis in 3 different transgenic mice models and their wild-type controls. We performed high-res (146x117x146 μm voxel) in vivo MRI with a 7 Tesla Bruker Biospec. MRS measurements were performed in two single voxels (4 and 7.5 mm 3) positioned respectively in the dorsal hippocampus and in the thalamus (PRESS sequence TR=2500 ms, TE=10 ms). We followed from 4 to 24 months single APP (PDAPP), double APPxPS-1 (TASTPM) and triple TAUSP2_APP transgenic mice. The metabolite contents were expressed as ratios over Creatine (Cr). The hippocampal volume shows a progressive atrophy in PDAPP and TAUSP2_APP; frontal cortex and striatum exhibited a progressive atrophy with time in all models. The progressive atrophy started in the cortex at 13 months in both TASTPM and TAUPS2_APP, while in PDAPP it occurred earlier. An increase in ventricle volume with aging was found in both PDAPP and TASTPM. The MRS analyses between the three models demonstrated distinct metabolic profiles. In particular, from 15 months a lower NAA/Cr (N-acetylaspartate) and higher mIns/Cr (myo-Inositol) content were found only in TASTPM with respect to wild-type controls. The structural and metabolic changes observed in these transgenic mice are partially reminiscent of the cerebral alterations occurring in familial AD subjects suggesting that these models are potentially relevant in translational studies of the effects of progressive Aβ deposition. The reduction of NAA/Cr found in TASTPM mice can be attributed to neuronal loss and/or dysfunction, and the elevation of myoinositol with microgliosis. The three transgenic models have in common, from a structural point of view, the progressive atrophy of the striatum and the frontal cortex. This research was conducted as part of the PharmaCog consortium (Grant Agreement n°115009, www.alzheimer-europe.org). The MRI analysis minimize the use of experimental animals and the protocols adopted have been approved by the internal ethical committee and Italian Minister of Health." @default.
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• W2018561922 date "2013-07-01" @default.
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• W2018561922 title "P1-258: Magnetic resonance imaging and Alzheimer's disease: Longitudinal studies of structural and metabolic changes in different transgenic mice models" @default.
• W2018561922 doi "https://doi.org/10.1016/j.jalz.2013.05.483" @default.
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