Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018575079> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2018575079 endingPage "S205" @default.
- W2018575079 startingPage "S205" @default.
- W2018575079 abstract "CXCR4, the receptor for stromal cell-derived factor-1(SDF-1), belongs to the chemokine receptor family and has been shown to play an important role in regulating the directional migration of breast cancer cells to sites of metastasis. In the present study, we evaluated the expression of CXCR4 and its association with pathological features and clinical outcome in human breast cancer. Expression of CXCR4 in eight breast cancer cell lines and breast cancer tissues was investigated using conventional PCR. Levels of CXCR4 transcript and protein were examined in human breast cancer tissues (n=120) and corresponding normal tissues (n=32) using real-time quantitative PCR and immunohistochemistry, respectively. The level of CXCR4 expression was analyzed against tumour types, grade, nodal status, recurrence, metastasis, and survival over a median 120 month follow-up period. The expression of CXCR4 was detected in all breast cancer cell lines examined, as well as in breast cancer tissues and breast normal tissues. Breast cancer tissues highly expressed CXCR4 compared with corresponding normal tissues (P=0.029). The level of CXCR4 expression showed a significant difference between node-positive group and node-negative group (19±13 vs. 49.7±9, respectively, P=0.03). The level of CXCR4 expression was marginal, yet statistically insignificant, higher in tumours from patients with metastatic disease compared with those who remained disease free. No correlation was seen between levels of CXCR4 and the overall survival, although at higher levels of CXCR4 linked to shorter disease free survival (113.0 vs. 136.7 months in patients with low CXCR4, P=0.14, Cox proportional test). The level of CXCR4 expression is significantly correlated with lymph node metastasis. The elevated levels of CXCR4 suggest that the patient has high possibility of lymph node metastasis. CXCR4 may be a useful prognostic indicator and a potential therapeutic target in cancer therapies in patients with breast cancer." @default.
- W2018575079 created "2016-06-24" @default.
- W2018575079 creator A5006269574 @default.
- W2018575079 creator A5031087276 @default.
- W2018575079 creator A5065464707 @default.
- W2018575079 date "2011-09-01" @default.
- W2018575079 modified "2023-09-26" @default.
- W2018575079 title "Study of the silibinine effect on the growth of MDA-MB-231 breast cancer cell lines and chemokine receptor of CXCR4 CCR7 genes" @default.
- W2018575079 doi "https://doi.org/10.1016/j.clinbiochem.2011.08.507" @default.
- W2018575079 hasPublicationYear "2011" @default.
- W2018575079 type Work @default.
- W2018575079 sameAs 2018575079 @default.
- W2018575079 citedByCount "0" @default.
- W2018575079 crossrefType "journal-article" @default.
- W2018575079 hasAuthorship W2018575079A5006269574 @default.
- W2018575079 hasAuthorship W2018575079A5031087276 @default.
- W2018575079 hasAuthorship W2018575079A5065464707 @default.
- W2018575079 hasConcept C111683008 @default.
- W2018575079 hasConcept C118646709 @default.
- W2018575079 hasConcept C121608353 @default.
- W2018575079 hasConcept C126322002 @default.
- W2018575079 hasConcept C127801297 @default.
- W2018575079 hasConcept C12823836 @default.
- W2018575079 hasConcept C129470790 @default.
- W2018575079 hasConcept C13373296 @default.
- W2018575079 hasConcept C142724271 @default.
- W2018575079 hasConcept C143998085 @default.
- W2018575079 hasConcept C16930146 @default.
- W2018575079 hasConcept C170493617 @default.
- W2018575079 hasConcept C204232928 @default.
- W2018575079 hasConcept C2776610909 @default.
- W2018575079 hasConcept C2779013556 @default.
- W2018575079 hasConcept C502942594 @default.
- W2018575079 hasConcept C530470458 @default.
- W2018575079 hasConcept C71924100 @default.
- W2018575079 hasConcept C86803240 @default.
- W2018575079 hasConceptScore W2018575079C111683008 @default.
- W2018575079 hasConceptScore W2018575079C118646709 @default.
- W2018575079 hasConceptScore W2018575079C121608353 @default.
- W2018575079 hasConceptScore W2018575079C126322002 @default.
- W2018575079 hasConceptScore W2018575079C127801297 @default.
- W2018575079 hasConceptScore W2018575079C12823836 @default.
- W2018575079 hasConceptScore W2018575079C129470790 @default.
- W2018575079 hasConceptScore W2018575079C13373296 @default.
- W2018575079 hasConceptScore W2018575079C142724271 @default.
- W2018575079 hasConceptScore W2018575079C143998085 @default.
- W2018575079 hasConceptScore W2018575079C16930146 @default.
- W2018575079 hasConceptScore W2018575079C170493617 @default.
- W2018575079 hasConceptScore W2018575079C204232928 @default.
- W2018575079 hasConceptScore W2018575079C2776610909 @default.
- W2018575079 hasConceptScore W2018575079C2779013556 @default.
- W2018575079 hasConceptScore W2018575079C502942594 @default.
- W2018575079 hasConceptScore W2018575079C530470458 @default.
- W2018575079 hasConceptScore W2018575079C71924100 @default.
- W2018575079 hasConceptScore W2018575079C86803240 @default.
- W2018575079 hasIssue "13" @default.
- W2018575079 hasLocation W20185750791 @default.
- W2018575079 hasOpenAccess W2018575079 @default.
- W2018575079 hasPrimaryLocation W20185750791 @default.
- W2018575079 hasRelatedWork W1452354713 @default.
- W2018575079 hasRelatedWork W1505208562 @default.
- W2018575079 hasRelatedWork W174389242 @default.
- W2018575079 hasRelatedWork W1980475208 @default.
- W2018575079 hasRelatedWork W2024594909 @default.
- W2018575079 hasRelatedWork W2061643043 @default.
- W2018575079 hasRelatedWork W2354669922 @default.
- W2018575079 hasRelatedWork W2391546368 @default.
- W2018575079 hasRelatedWork W2407768814 @default.
- W2018575079 hasRelatedWork W4254528777 @default.
- W2018575079 hasVolume "44" @default.
- W2018575079 isParatext "false" @default.
- W2018575079 isRetracted "false" @default.
- W2018575079 magId "2018575079" @default.
- W2018575079 workType "article" @default.