FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018581247> ?p ?o ?g. }

• W2018581247 endingPage "58" @default.
• W2018581247 startingPage "47" @default.
• W2018581247 abstract "Induction of heat shock-related stress proteins Pfhsp and Pfgrp, similar in sequence to hsp70 (heat shock protein) and grp78 (glucose-regulated protein), respectively, was studied in culture-derived parasite Plasmodium falciparum. Elevation in temperature from 26 degrees C to 37 degrees C and higher caused significant induction of Pfhsp with a moderate effect on the synthesis of Pfgrp also. Synthesis of Pfgrp, however, was not induced by partial glucose deprivation. On the contrary, lack of glucose in the medium resulted in cessation of protein synthesis in the parasites. Other known inducers of grp synthesis in mammalian cells, i.e., calcium ionophore A23187 and inhibitors of glycosylation (tunicamycin, 2-deoxy glucose) were also without any apparent effect on the synthesis of Pfgrp. Heat shock-induced responses were transient in nature: removal of stress caused repression of these responses. The effect of glucose deprivation was only partially reversible with better recovery if parasites were subjected to glucose starvation at 26 degrees C than at 37 degrees C. Northern blot analysis and in vitro translation of mRNA revealed a parallel increase in the levels of mRNA for Pfhsp upon heat shock. Immuno-gold electron microscopy with cultured parasites revealed nuclear location of Pfhsp and primarily cytoplasmic (probably endoplasmic reticulum) location of Pfgrp. These findings suggest that SDEL (carboxy terminal sequence of Pfgrp) might play a similar role in the cellular localization of Pfgrp as does the sequence KDEL in mammalian cells and HDEL in yeast." @default.
• W2018581247 created "2016-06-24" @default.
• W2018581247 creator A5010287780 @default.
• W2018581247 creator A5055673972 @default.
• W2018581247 creator A5062615352 @default.
• W2018581247 creator A5064861833 @default.
• W2018581247 creator A5089797668 @default.
• W2018581247 date "1991-09-01" @default.
• W2018581247 modified "2023-10-17" @default.
• W2018581247 title "Induction and localization of Plasmodium falciparum stress proteins related to the heat shock protein 70 family" @default.
• W2018581247 cites W1516276392 @default.
• W2018581247 cites W1614185919 @default.
• W2018581247 cites W1648904426 @default.
• W2018581247 cites W1899388892 @default.
• W2018581247 cites W1909596236 @default.
• W2018581247 cites W1969419906 @default.
• W2018581247 cites W1970732391 @default.
• W2018581247 cites W1977388184 @default.
• W2018581247 cites W1982011220 @default.
• W2018581247 cites W1986936966 @default.
• W2018581247 cites W1994744146 @default.
• W2018581247 cites W2005383788 @default.
• W2018581247 cites W2014002820 @default.
• W2018581247 cites W2020437934 @default.
• W2018581247 cites W2023966699 @default.
• W2018581247 cites W2031684542 @default.
• W2018581247 cites W2042985028 @default.
• W2018581247 cites W2043753352 @default.
• W2018581247 cites W2056037336 @default.
• W2018581247 cites W2061824817 @default.
• W2018581247 cites W2085326030 @default.
• W2018581247 cites W2093955069 @default.
• W2018581247 cites W2100508228 @default.
• W2018581247 cites W2100837269 @default.
• W2018581247 cites W2120092043 @default.
• W2018581247 cites W2145835877 @default.
• W2018581247 cites W2164179462 @default.
• W2018581247 cites W2165113979 @default.
• W2018581247 cites W2317559132 @default.
• W2018581247 cites W4294216491 @default.
• W2018581247 doi "https://doi.org/10.1016/0166-6851(91)90163-z" @default.
• W2018581247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1779989" @default.
• W2018581247 hasPublicationYear "1991" @default.
• W2018581247 type Work @default.
• W2018581247 sameAs 2018581247 @default.
• W2018581247 citedByCount "155" @default.
• W2018581247 countsByYear W20185812472012 @default.
• W2018581247 countsByYear W20185812472013 @default.
• W2018581247 countsByYear W20185812472014 @default.
• W2018581247 countsByYear W20185812472015 @default.
• W2018581247 countsByYear W20185812472016 @default.
• W2018581247 countsByYear W20185812472017 @default.
• W2018581247 countsByYear W20185812472018 @default.
• W2018581247 countsByYear W20185812472019 @default.
• W2018581247 countsByYear W20185812472020 @default.
• W2018581247 countsByYear W20185812472021 @default.
• W2018581247 countsByYear W20185812472022 @default.
• W2018581247 countsByYear W20185812472023 @default.
• W2018581247 crossrefType "journal-article" @default.
• W2018581247 hasAuthorship W2018581247A5010287780 @default.
• W2018581247 hasAuthorship W2018581247A5055673972 @default.
• W2018581247 hasAuthorship W2018581247A5062615352 @default.
• W2018581247 hasAuthorship W2018581247A5064861833 @default.
• W2018581247 hasAuthorship W2018581247A5089797668 @default.
• W2018581247 hasBestOaLocation W20185812471 @default.
• W2018581247 hasConcept C104317684 @default.
• W2018581247 hasConcept C119062480 @default.
• W2018581247 hasConcept C139447449 @default.
• W2018581247 hasConcept C153911025 @default.
• W2018581247 hasConcept C158617107 @default.
• W2018581247 hasConcept C205260736 @default.
• W2018581247 hasConcept C2777575526 @default.
• W2018581247 hasConcept C2780995651 @default.
• W2018581247 hasConcept C2781373781 @default.
• W2018581247 hasConcept C3675279 @default.
• W2018581247 hasConcept C55493867 @default.
• W2018581247 hasConcept C68991219 @default.
• W2018581247 hasConcept C86803240 @default.
• W2018581247 hasConceptScore W2018581247C104317684 @default.
• W2018581247 hasConceptScore W2018581247C119062480 @default.
• W2018581247 hasConceptScore W2018581247C139447449 @default.
• W2018581247 hasConceptScore W2018581247C153911025 @default.
• W2018581247 hasConceptScore W2018581247C158617107 @default.
• W2018581247 hasConceptScore W2018581247C205260736 @default.
• W2018581247 hasConceptScore W2018581247C2777575526 @default.
• W2018581247 hasConceptScore W2018581247C2780995651 @default.
• W2018581247 hasConceptScore W2018581247C2781373781 @default.
• W2018581247 hasConceptScore W2018581247C3675279 @default.
• W2018581247 hasConceptScore W2018581247C55493867 @default.
• W2018581247 hasConceptScore W2018581247C68991219 @default.
• W2018581247 hasConceptScore W2018581247C86803240 @default.
• W2018581247 hasIssue "1" @default.
• W2018581247 hasLocation W20185812471 @default.
• W2018581247 hasLocation W20185812472 @default.
• W2018581247 hasOpenAccess W2018581247 @default.
• W2018581247 hasPrimaryLocation W20185812471 @default.
• W2018581247 hasRelatedWork W1531324722 @default.
• W2018581247 hasRelatedWork W1996372072 @default.

• next