Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018582321> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2018582321 endingPage "848" @default.
- W2018582321 startingPage "839" @default.
- W2018582321 abstract "We have investigated the modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers by the neurohormone norepinephrine. We find that 0.5 microM norepinephrine increases this K channel current by a factor of 2.7. A maximal increase of about four was found for concentrations of 1 microM and above. Norepinephrine produced a small (less than 5 mV) and variable shift of the K channel reversal potential toward more negative values. The kinetics of the potassium channel are well described by a two-exponential process, both in the absence and presence of norepinephrine. However, norepinephrine substantially decreases the slower time constant with no significant effect on the fast time constant. Potassium channel activation curves in the presence of norepinephrine are very similar to control curves except at large positive potentials. A simple sequential three-state model for this channel can reproduce these data both with and without norepinephrine. The logarithms of the rate constants derived from this model are quadratic functions of voltage, suggesting the involvement of electric field-induced dipoles in the gating of this channel. Most of the kinetic effects of norepinephrine appear to be on a single rate constant." @default.
- W2018582321 created "2016-06-24" @default.
- W2018582321 creator A5014178831 @default.
- W2018582321 creator A5028340262 @default.
- W2018582321 creator A5057783545 @default.
- W2018582321 creator A5085075737 @default.
- W2018582321 date "1986-04-01" @default.
- W2018582321 modified "2023-10-02" @default.
- W2018582321 title "Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers" @default.
- W2018582321 cites W1969797153 @default.
- W2018582321 cites W1974323167 @default.
- W2018582321 cites W1984336411 @default.
- W2018582321 cites W1986355133 @default.
- W2018582321 cites W2004047950 @default.
- W2018582321 cites W2008289905 @default.
- W2018582321 cites W2013011061 @default.
- W2018582321 cites W2015724584 @default.
- W2018582321 cites W2018931883 @default.
- W2018582321 cites W2028237738 @default.
- W2018582321 cites W2034223710 @default.
- W2018582321 cites W2036874203 @default.
- W2018582321 cites W2042217106 @default.
- W2018582321 cites W2044586377 @default.
- W2018582321 cites W2045376669 @default.
- W2018582321 cites W2047631697 @default.
- W2018582321 cites W2069450192 @default.
- W2018582321 cites W2069642958 @default.
- W2018582321 cites W2080039322 @default.
- W2018582321 cites W2080962219 @default.
- W2018582321 cites W2085188793 @default.
- W2018582321 cites W2087403500 @default.
- W2018582321 cites W2088914168 @default.
- W2018582321 cites W2112217263 @default.
- W2018582321 cites W2125366542 @default.
- W2018582321 cites W2403277721 @default.
- W2018582321 cites W2416824523 @default.
- W2018582321 cites W2886104155 @default.
- W2018582321 cites W4289965383 @default.
- W2018582321 doi "https://doi.org/10.1016/s0006-3495(86)83713-4" @default.
- W2018582321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1329536" @default.
- W2018582321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2424513" @default.
- W2018582321 hasPublicationYear "1986" @default.
- W2018582321 type Work @default.
- W2018582321 sameAs 2018582321 @default.
- W2018582321 citedByCount "68" @default.
- W2018582321 countsByYear W20185823212012 @default.
- W2018582321 countsByYear W20185823212015 @default.
- W2018582321 countsByYear W20185823212022 @default.
- W2018582321 crossrefType "journal-article" @default.
- W2018582321 hasAuthorship W2018582321A5014178831 @default.
- W2018582321 hasAuthorship W2018582321A5028340262 @default.
- W2018582321 hasAuthorship W2018582321A5057783545 @default.
- W2018582321 hasAuthorship W2018582321A5085075737 @default.
- W2018582321 hasBestOaLocation W20185823211 @default.
- W2018582321 hasConcept C126322002 @default.
- W2018582321 hasConcept C134018914 @default.
- W2018582321 hasConcept C178790620 @default.
- W2018582321 hasConcept C185592680 @default.
- W2018582321 hasConcept C2778514916 @default.
- W2018582321 hasConcept C513476851 @default.
- W2018582321 hasConcept C517785266 @default.
- W2018582321 hasConcept C71924100 @default.
- W2018582321 hasConcept C83743174 @default.
- W2018582321 hasConcept C86803240 @default.
- W2018582321 hasConceptScore W2018582321C126322002 @default.
- W2018582321 hasConceptScore W2018582321C134018914 @default.
- W2018582321 hasConceptScore W2018582321C178790620 @default.
- W2018582321 hasConceptScore W2018582321C185592680 @default.
- W2018582321 hasConceptScore W2018582321C2778514916 @default.
- W2018582321 hasConceptScore W2018582321C513476851 @default.
- W2018582321 hasConceptScore W2018582321C517785266 @default.
- W2018582321 hasConceptScore W2018582321C71924100 @default.
- W2018582321 hasConceptScore W2018582321C83743174 @default.
- W2018582321 hasConceptScore W2018582321C86803240 @default.
- W2018582321 hasIssue "4" @default.
- W2018582321 hasLocation W20185823211 @default.
- W2018582321 hasLocation W20185823212 @default.
- W2018582321 hasLocation W20185823213 @default.
- W2018582321 hasLocation W20185823214 @default.
- W2018582321 hasOpenAccess W2018582321 @default.
- W2018582321 hasPrimaryLocation W20185823211 @default.
- W2018582321 hasRelatedWork W1973095062 @default.
- W2018582321 hasRelatedWork W1997653766 @default.
- W2018582321 hasRelatedWork W2006923825 @default.
- W2018582321 hasRelatedWork W2007920416 @default.
- W2018582321 hasRelatedWork W2029739536 @default.
- W2018582321 hasRelatedWork W2044985824 @default.
- W2018582321 hasRelatedWork W2054491688 @default.
- W2018582321 hasRelatedWork W2166688422 @default.
- W2018582321 hasRelatedWork W2324925659 @default.
- W2018582321 hasRelatedWork W2400592423 @default.
- W2018582321 hasVolume "49" @default.
- W2018582321 isParatext "false" @default.
- W2018582321 isRetracted "false" @default.
- W2018582321 magId "2018582321" @default.
- W2018582321 workType "article" @default.