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- W2018585764 abstract "Congenital chloride diarrhea is a rare autosomal recessive disorder characterized by defective chloride-bicarbonate exchange in the ileum and possibly the colon, which results in diarrhea with marked losses of chloride in the stool [l-3]. Diarrhea usually begins within the first 24 hours after birth and may result in hypovolemia and chronic metabolic alkalosis due to chloride depletion. With aggressive sodium and potassium chloride replacement beginning in infancy, normal development and survival into adulthood are possible [2]. To our knowledge, this is the first report of a patient with this disorder who has survived to adulthood without major complications, except impairment of renal function, while receiving no specific therapy to correct the associated metabolic abnormalities. Chloride-responsive metabolic alkalosis related to chloride depletion and chloride-resistant metabolic alkalosis related to coexisting profound potassium depletion have both been observed in the course of clinical evaluation." @default.
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- W2018585764 date "1988-10-01" @default.
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- W2018585764 title "Chloride-resistant metabolic alkalosis in an adult with congenital chloride diarrhea" @default.
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- W2018585764 doi "https://doi.org/10.1016/s0002-9343(88)80101-3" @default.
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