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- W201858718 abstract "Activation of innate and adaptive immune responses in drug-induced liver injury (DILI) is a response to an initial hepatocellular injury during xenobiotic metabolism. Indeed, in most cases of DILI, this secondary activation of the immune response is required for acute liver failure. Kupffer cells, the resident macrophages in the liver, as well as peripheral monocytes/macrophages recruited to the liver, have complex roles in the response of the liver to injury. An initial activation of macrophages is part of the innate immune response to endogenously produced danger signals (or DAMPs) and facilitates the recovery of the liver following injury. However, if the activation of hepatic macrophages is not appropriately resolved, then activated macrophages can contribute to the uncontrolled expression of proinflammatory cytokines and further exacerbate injury in the liver. Understanding the protective versus harmful effects of hepatic macrophages in DILI may facilitate the development of therapeutic strategies for improving clinical outcomes in DILI." @default.
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- W201858718 date "2013-01-01" @default.
- W201858718 modified "2023-09-23" @default.
- W201858718 title "Macrophages and Kupffer Cells in Drug-Induced Liver Injury" @default.
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- W201858718 doi "https://doi.org/10.1016/b978-0-12-387817-5.00009-1" @default.
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