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- W2018589822 abstract "Stable mutant strains of Leishmania tarentolae promastigotes resistant to chloramphenicol (CAP) were isolated by replica-plating techniques. In addition, cell lines stress-adapted to streptomycin and to high culture temperature (33 C) were obtained. Drug resistance was influenced by temperature, culture media, and plating technique. Inhibition of amino acid incorporation into protein occurs in CAP-resistant cells when exposed to 600 μg CAP/ml but this inhibition was 50–80% lower than that found in wild type sensitive cells. The primary site of CAP action appears to be inhibition of protein synthesis. CAP also adversely affected proline oxidation." @default.
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- W2018589822 date "1976-04-01" @default.
- W2018589822 modified "2023-09-27" @default.
- W2018589822 title "Leishmania tarentolae: Streptomycin and chloramphenicol resistance of promastigotes" @default.
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- W2018589822 doi "https://doi.org/10.1016/0014-4894(76)90122-3" @default.
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