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- W2018590127 abstract "It is now customary practice to couple separately metered infusions via a manifold to a common catheter that enters the patient. Nitroprusside, however, is considered incompatible with all other medications. Critically ill patients who require multiple infusions of vasoactive and inotropic medications would benefit if physicians had additional information regarding compatibility of nitroprusside with other commonly used infusions. Utilizing high-performance liquid chromatography, the authors investigated the physical and chemical compatibility of nitroprusside, dobutamine, and nitroglycerin in solutions of 5% dextrose or 0.9% NaCl at clinically relevant concentrations. AH drugs were present within the guidelines of the U.S. Pharmacopeia (±10%) over 24 h in NaCl, but nitroglycerin degraded over 24 h when the three drugs were mixed in dextrose. We recommend diluting these medicines in NaCl when mixtures of them would exist for ≥ h." @default.
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- W2018590127 date "1990-08-01" @default.
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- W2018590127 title "Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible" @default.
- W2018590127 doi "https://doi.org/10.1097/00003246-199008000-00013" @default.
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