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- W2018590483 abstract "Habituation of rats to the testing environment and procedures reduces flexor withdrawal latencies to those of spinalised animals. We have now recorded surface temperatures at 3 sites on the tail and tail-flick latencies simultaneously in experimentally naive (novice) rats and in habituated rats. At usual ambient temperatures (20 ± 1°C), tail temperatures fluctuated in accordance with the predictions of an on-off controller. There was an inverse correlation between the tail-flick latency and the temperature at the site of noxious stimulation. A similar correlation was found when the pre-stimulus temperature of the tip of the tail was held at temperatures ranging from 21°C to 35°C. Habituated animals exhibited a similar linear regression slope factor but lower latencies than novice animals at each temperature. We conclude (1) that tail-flick latency is determined partly by the pre-stimulus temperature at the site of noxious thermal stimulation, and (2) that the effects of habituation on tail-flick latency are more likely to be explained by differences in nociception than in regional vasomotor tone." @default.
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- W2018590483 date "1989-10-01" @default.
- W2018590483 modified "2023-09-27" @default.
- W2018590483 title "Habituation to sham testing procedures modifies tail-flick latencies: Effects on nociception rather than vasomotor tone" @default.
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- W2018590483 doi "https://doi.org/10.1016/0304-3959(89)90180-2" @default.
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