FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018590883> ?p ?o ?g. }

• W2018590883 endingPage "2600" @default.
• W2018590883 startingPage "2595" @default.
• W2018590883 abstract "Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. Histone deacetylase inhibitors (HDACi) have highly effective anti-metastatic and anti-angiogenic activity in various types of cancer, while the molecular mechanisms involved in this process are not fully understood. In the present study, trichostatin A (TSA), a HDACi, was found to suppress MCF-7 breast carcinoma cell invasion and upregulate TET1 expression in a dose-dependent manner. TET1, a dioxygenase involved in cytosine demethylation, is downregulated during breast cancer progression. TET1 knockdown in MCF-7 cells facilitates cell invasion, inhibits the expression of tissue inhibitors of metalloproteinase 2/3 (TIMP2/3) and promotes matrix metalloproteinases (MMP) 2/9 transcriptional activity. Importantly, TET1 depletion impaired the inhibitory effect of TSA on breast cancer cell invasion. Together, these results illustrated a mechanism by which TET1 partially mediates HDACi elicited suppression of breast cancer invasion." @default.
• W2018590883 created "2016-06-24" @default.
• W2018590883 creator A5000009653 @default.
• W2018590883 creator A5010458663 @default.
• W2018590883 creator A5014975276 @default.
• W2018590883 creator A5015782146 @default.
• W2018590883 creator A5016700682 @default.
• W2018590883 creator A5018925855 @default.
• W2018590883 creator A5034620850 @default.
• W2018590883 creator A5036045846 @default.
• W2018590883 creator A5043069455 @default.
• W2018590883 creator A5063710096 @default.
• W2018590883 creator A5064437687 @default.
• W2018590883 creator A5073800512 @default.
• W2018590883 creator A5079454108 @default.
• W2018590883 date "2014-08-26" @default.
• W2018590883 modified "2023-10-18" @default.
• W2018590883 title "TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion" @default.
• W2018590883 cites W1498135837 @default.
• W2018590883 cites W1967018540 @default.
• W2018590883 cites W1970145665 @default.
• W2018590883 cites W1973962086 @default.
• W2018590883 cites W1974006411 @default.
• W2018590883 cites W1977208190 @default.
• W2018590883 cites W1979397921 @default.
• W2018590883 cites W1991718508 @default.
• W2018590883 cites W1994567037 @default.
• W2018590883 cites W1994705026 @default.
• W2018590883 cites W1997914837 @default.
• W2018590883 cites W2003356506 @default.
• W2018590883 cites W2008054969 @default.
• W2018590883 cites W2011660168 @default.
• W2018590883 cites W2014623973 @default.
• W2018590883 cites W2019084941 @default.
• W2018590883 cites W2042146687 @default.
• W2018590883 cites W2043103956 @default.
• W2018590883 cites W2057607475 @default.
• W2018590883 cites W2060719968 @default.
• W2018590883 cites W2065084243 @default.
• W2018590883 cites W2071205030 @default.
• W2018590883 cites W2072106835 @default.
• W2018590883 cites W2072259101 @default.
• W2018590883 cites W2075116781 @default.
• W2018590883 cites W2088296885 @default.
• W2018590883 cites W2094964650 @default.
• W2018590883 cites W2101292434 @default.
• W2018590883 cites W2104591325 @default.
• W2018590883 cites W2119391432 @default.
• W2018590883 cites W2137598443 @default.
• W2018590883 cites W2149386327 @default.
• W2018590883 cites W2158971210 @default.
• W2018590883 cites W2331534532 @default.
• W2018590883 cites W3190412754 @default.
• W2018590883 cites W4211075966 @default.
• W2018590883 doi "https://doi.org/10.3892/mmr.2014.2517" @default.
• W2018590883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25175940" @default.
• W2018590883 hasPublicationYear "2014" @default.
• W2018590883 type Work @default.
• W2018590883 sameAs 2018590883 @default.
• W2018590883 citedByCount "18" @default.
• W2018590883 countsByYear W20185908832015 @default.
• W2018590883 countsByYear W20185908832016 @default.
• W2018590883 countsByYear W20185908832017 @default.
• W2018590883 countsByYear W20185908832018 @default.
• W2018590883 countsByYear W20185908832019 @default.
• W2018590883 countsByYear W20185908832020 @default.
• W2018590883 countsByYear W20185908832021 @default.
• W2018590883 countsByYear W20185908832022 @default.
• W2018590883 countsByYear W20185908832023 @default.
• W2018590883 crossrefType "journal-article" @default.
• W2018590883 hasAuthorship W2018590883A5000009653 @default.
• W2018590883 hasAuthorship W2018590883A5010458663 @default.
• W2018590883 hasAuthorship W2018590883A5014975276 @default.
• W2018590883 hasAuthorship W2018590883A5015782146 @default.
• W2018590883 hasAuthorship W2018590883A5016700682 @default.
• W2018590883 hasAuthorship W2018590883A5018925855 @default.
• W2018590883 hasAuthorship W2018590883A5034620850 @default.
• W2018590883 hasAuthorship W2018590883A5036045846 @default.
• W2018590883 hasAuthorship W2018590883A5043069455 @default.
• W2018590883 hasAuthorship W2018590883A5063710096 @default.
• W2018590883 hasAuthorship W2018590883A5064437687 @default.
• W2018590883 hasAuthorship W2018590883A5073800512 @default.
• W2018590883 hasAuthorship W2018590883A5079454108 @default.
• W2018590883 hasBestOaLocation W20185908831 @default.
• W2018590883 hasConcept C104317684 @default.
• W2018590883 hasConcept C121608353 @default.
• W2018590883 hasConcept C167227067 @default.
• W2018590883 hasConcept C173396325 @default.
• W2018590883 hasConcept C190283241 @default.
• W2018590883 hasConcept C2776202225 @default.
• W2018590883 hasConcept C2777865847 @default.
• W2018590883 hasConcept C2778305200 @default.
• W2018590883 hasConcept C2781018059 @default.
• W2018590883 hasConcept C29537977 @default.
• W2018590883 hasConcept C41091548 @default.
• W2018590883 hasConcept C502942594 @default.
• W2018590883 hasConcept C530470458 @default.
• W2018590883 hasConcept C54355233 @default.

• next