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• W2018595535 abstract "Oxygen is necessary for maintaining cell proliferation and viability and extracellular matrix (ECM) production in 3-dimensional tissue engineering. Typically, diffusion is the primary mode for oxygen transport in vitro; thus, ensuring an adequate oxygen supply is essential. In this study, we determined the oxygen diffusion coefficients of 3 natural ECMs that are being investigated as construct scaffolds for tendon tissue engineering: small-intestine submucosa (SIS), human dermis (Alloderm), and canine fascia lata. Diffusion coefficients were determined using a standard diffusion cell system. The ranges for each matrix type were: SIS: 7 x 10(-6) - 2 x 10(-5) cm2/s, Alloderm: 1.9 - 3.1 x 10(-5) cm2/s, and canine fascia lata: 1.6 - 4 x 10(-5) cm2/s. We used the experimental oxygen diffusivity data for these natural ECMs in a mathematical model of oxygen diffusion through a cell-seeded scaffold to estimate the critical size of cell-seeded scaffold that can be cultured in vitro." @default.
• W2018595535 created "2016-06-24" @default.
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• W2018595535 date "2008-04-01" @default.
• W2018595535 modified "2023-10-14" @default.
• W2018595535 title "Oxygen Diffusion through Natural Extracellular Matrices: Implications for Estimating “Critical Thickness” Values in Tendon Tissue Engineering" @default.
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• W2018595535 doi "https://doi.org/10.1089/tea.2006.0361" @default.
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