Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018602018> ?p ?o ?g. }
- W2018602018 endingPage "8" @default.
- W2018602018 startingPage "1" @default.
- W2018602018 abstract "Summary The non‐dialysable proteins present in the latex of plant Calotropis procera possess anti‐inflammatory and analgesic properties. The aim of this study was to evaluate the effect of latex proteins ( LP ) on the level of inflammatory mediators, oxidative stress markers and tissue histology in the rat model of carrageenan‐induced acute inflammation. This study also aimed at evaluating the anti‐inflammatory efficacy of LP against different mediators and comparing it with their respective antagonists. Paw inflammation was induced by subplantar injection of carrageenan, and the effect of LP was evaluated on oedema volume, level of TNF ‐α, PGE 2 , myeloperoxidase, nitric oxide, reduced glutathione, thiobarbituric acid‐reactive substances and tissue histology at the time of peak inflammation. Paw inflammation was also induced by histamine, serotonin, bradykinin and PGE 2 , and the inhibitory effect of LP against these mediators was compared with their respective antagonists at the time of peak effect. Treatment with LP produced a dose‐dependent inhibition of oedema formation, and its anti‐inflammatory effect against carrageenan‐induced paw inflammation was accompanied by reduction in the levels of inflammatory mediators, oxidative stress markers and normalization of tissue architecture. LP also produced a dose‐dependent inhibition of oedema formation induced by different inflammatory mediators, and its efficacy was comparable to their respective antagonists and more pronounced than that of diclofenac. Thus, our study shows that LP has a potential to be used for the treatment of various inflammatory conditions where the role of these mediators is well established." @default.
- W2018602018 created "2016-06-24" @default.
- W2018602018 creator A5019919335 @default.
- W2018602018 creator A5025250448 @default.
- W2018602018 creator A5041279326 @default.
- W2018602018 creator A5045822471 @default.
- W2018602018 creator A5052691457 @default.
- W2018602018 creator A5065279528 @default.
- W2018602018 date "2015-04-17" @default.
- W2018602018 modified "2023-10-05" @default.
- W2018602018 title "Protective effect of proteins derived from<i>Calotropis procera</i>latex against acute inflammation in rat" @default.
- W2018602018 cites W1549887147 @default.
- W2018602018 cites W1866959613 @default.
- W2018602018 cites W1969482797 @default.
- W2018602018 cites W1969733378 @default.
- W2018602018 cites W1974588272 @default.
- W2018602018 cites W1981819970 @default.
- W2018602018 cites W1983310681 @default.
- W2018602018 cites W1984055946 @default.
- W2018602018 cites W1989953567 @default.
- W2018602018 cites W1996462445 @default.
- W2018602018 cites W1998223853 @default.
- W2018602018 cites W2006370393 @default.
- W2018602018 cites W2007187686 @default.
- W2018602018 cites W2014234970 @default.
- W2018602018 cites W2020358486 @default.
- W2018602018 cites W2020493471 @default.
- W2018602018 cites W2031084334 @default.
- W2018602018 cites W2032999990 @default.
- W2018602018 cites W2037186296 @default.
- W2018602018 cites W2052908553 @default.
- W2018602018 cites W2058012462 @default.
- W2018602018 cites W2059043613 @default.
- W2018602018 cites W2066881328 @default.
- W2018602018 cites W2066913925 @default.
- W2018602018 cites W2069518932 @default.
- W2018602018 cites W2078077176 @default.
- W2018602018 cites W2078259729 @default.
- W2018602018 cites W2115412021 @default.
- W2018602018 cites W2121295785 @default.
- W2018602018 cites W2129935236 @default.
- W2018602018 cites W3022468203 @default.
- W2018602018 doi "https://doi.org/10.1111/aap.12022" @default.
- W2018602018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25882716" @default.
- W2018602018 hasPublicationYear "2015" @default.
- W2018602018 type Work @default.
- W2018602018 sameAs 2018602018 @default.
- W2018602018 citedByCount "14" @default.
- W2018602018 countsByYear W20186020182015 @default.
- W2018602018 countsByYear W20186020182016 @default.
- W2018602018 countsByYear W20186020182017 @default.
- W2018602018 countsByYear W20186020182018 @default.
- W2018602018 countsByYear W20186020182019 @default.
- W2018602018 countsByYear W20186020182020 @default.
- W2018602018 countsByYear W20186020182021 @default.
- W2018602018 countsByYear W20186020182022 @default.
- W2018602018 countsByYear W20186020182023 @default.
- W2018602018 crossrefType "journal-article" @default.
- W2018602018 hasAuthorship W2018602018A5019919335 @default.
- W2018602018 hasAuthorship W2018602018A5025250448 @default.
- W2018602018 hasAuthorship W2018602018A5041279326 @default.
- W2018602018 hasAuthorship W2018602018A5045822471 @default.
- W2018602018 hasAuthorship W2018602018A5052691457 @default.
- W2018602018 hasAuthorship W2018602018A5065279528 @default.
- W2018602018 hasConcept C1122143 @default.
- W2018602018 hasConcept C170493617 @default.
- W2018602018 hasConcept C181199279 @default.
- W2018602018 hasConcept C185592680 @default.
- W2018602018 hasConcept C203014093 @default.
- W2018602018 hasConcept C203565725 @default.
- W2018602018 hasConcept C2776151105 @default.
- W2018602018 hasConcept C2776914184 @default.
- W2018602018 hasConcept C2779406593 @default.
- W2018602018 hasConcept C2779591629 @default.
- W2018602018 hasConcept C2779703632 @default.
- W2018602018 hasConcept C2781227287 @default.
- W2018602018 hasConcept C538909803 @default.
- W2018602018 hasConcept C55493867 @default.
- W2018602018 hasConcept C556039675 @default.
- W2018602018 hasConcept C71924100 @default.
- W2018602018 hasConcept C98274493 @default.
- W2018602018 hasConceptScore W2018602018C1122143 @default.
- W2018602018 hasConceptScore W2018602018C170493617 @default.
- W2018602018 hasConceptScore W2018602018C181199279 @default.
- W2018602018 hasConceptScore W2018602018C185592680 @default.
- W2018602018 hasConceptScore W2018602018C203014093 @default.
- W2018602018 hasConceptScore W2018602018C203565725 @default.
- W2018602018 hasConceptScore W2018602018C2776151105 @default.
- W2018602018 hasConceptScore W2018602018C2776914184 @default.
- W2018602018 hasConceptScore W2018602018C2779406593 @default.
- W2018602018 hasConceptScore W2018602018C2779591629 @default.
- W2018602018 hasConceptScore W2018602018C2779703632 @default.
- W2018602018 hasConceptScore W2018602018C2781227287 @default.
- W2018602018 hasConceptScore W2018602018C538909803 @default.
- W2018602018 hasConceptScore W2018602018C55493867 @default.
- W2018602018 hasConceptScore W2018602018C556039675 @default.
- W2018602018 hasConceptScore W2018602018C71924100 @default.
- W2018602018 hasConceptScore W2018602018C98274493 @default.