FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018604414> ?p ?o ?g. }

• W2018604414 endingPage "e96916" @default.
• W2018604414 startingPage "e96916" @default.
• W2018604414 abstract "Aims Oxidative stress is involved in the pathophysiology of diabetic nephropathy. Manganese superoxide dismutase (SOD2) catalyses the dismutation of superoxide, regulates the metabolism of reactive oxygen species in the mitochondria and is highly expressed in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, was found to be increased in patients with kidney disease. We investigated associations of SOD2 allelic variations, plasma SOD activity and AOPP concentration with diabetic nephropathy in type 1 diabetic subjects. Methods Eight SNPs in the SOD2 region were analysed in 1285 Caucasian subjects with type 1 diabetes from the SURGENE prospective study (n = 340; 10-year follow-up), GENESIS (n = 501) and GENEDIAB (n = 444) cross-sectional studies. Baseline plasma concentration of AOPP and SOD activity were measured in GENEDIAB participants. Hazard ratio (HR) and odds ratio (OR) were determined for incidence and prevalence of nephropathy. Analyses were adjusted or stratified by retinopathy stages. Results In the SURGENE cohort, the T-allele of rs4880 (V16A) was associated with the incidence of renal events (new cases, or the progression to a more severe stage of nephropathy; HR 1.99, 95% CI 1.24–3.12, p = 0.004) and with the decline in estimated glomerular filtration rate (eGFR) during follow-up. Similar associations were observed for rs2758329 and rs8031. Associations were replicated in GENESIS/GENEDIAB cohorts, in the subset of participants without proliferative retinopathy, and were confirmed by haplotype analyses. Risk allele and haplotype were also associated with higher plasma AOPP concentration and lower SOD activity. Conclusions SOD2 allelic variations were associated with the incidence and the progression of diabetic nephropathy, with a faster decline in eGFR and with plasma AOPP concentration and SOD activity in subjects with type 1 diabetes. These results are consistent with a role for SOD2 in the protection against oxidative stress and kidney disease in type 1 diabetes." @default.
• W2018604414 created "2016-06-24" @default.
• W2018604414 creator A5000309355 @default.
• W2018604414 creator A5010956554 @default.
• W2018604414 creator A5022075731 @default.
• W2018604414 creator A5038737554 @default.
• W2018604414 creator A5039339457 @default.
• W2018604414 creator A5041016069 @default.
• W2018604414 creator A5043088478 @default.
• W2018604414 creator A5057869899 @default.
• W2018604414 creator A5057920610 @default.
• W2018604414 date "2014-05-12" @default.
• W2018604414 modified "2023-10-16" @default.
• W2018604414 title "Manganese Superoxide Dismutase (SOD2) Polymorphisms, Plasma Advanced Oxidation Protein Products (AOPP) Concentration and Risk of Kidney Complications in Subjects with Type 1 Diabetes" @default.
• W2018604414 cites W1559531158 @default.
• W2018604414 cites W1802861244 @default.
• W2018604414 cites W1991399924 @default.
• W2018604414 cites W2011683287 @default.
• W2018604414 cites W2012749910 @default.
• W2018604414 cites W2016475020 @default.
• W2018604414 cites W2022460877 @default.
• W2018604414 cites W2030705868 @default.
• W2018604414 cites W2030899891 @default.
• W2018604414 cites W2042641359 @default.
• W2018604414 cites W2044437167 @default.
• W2018604414 cites W2055112763 @default.
• W2018604414 cites W2055864845 @default.
• W2018604414 cites W2056271246 @default.
• W2018604414 cites W2057083381 @default.
• W2018604414 cites W2059378550 @default.
• W2018604414 cites W2059407142 @default.
• W2018604414 cites W2060033647 @default.
• W2018604414 cites W2066608222 @default.
• W2018604414 cites W2068558742 @default.
• W2018604414 cites W2071072496 @default.
• W2018604414 cites W2095855977 @default.
• W2018604414 cites W2100596792 @default.
• W2018604414 cites W2103411650 @default.
• W2018604414 cites W2110812051 @default.
• W2018604414 cites W2114443210 @default.
• W2018604414 cites W2121633948 @default.
• W2018604414 cites W2126792731 @default.
• W2018604414 cites W2127923665 @default.
• W2018604414 cites W2129591434 @default.
• W2018604414 cites W2131809691 @default.
• W2018604414 cites W2139711170 @default.
• W2018604414 cites W2140454304 @default.
• W2018604414 cites W2142693924 @default.
• W2018604414 cites W2148641840 @default.
• W2018604414 cites W2159758267 @default.
• W2018604414 cites W2166500288 @default.
• W2018604414 cites W2187106138 @default.
• W2018604414 cites W2471605942 @default.
• W2018604414 cites W2769264260 @default.
• W2018604414 cites W4237857420 @default.
• W2018604414 cites W4255624811 @default.
• W2018604414 doi "https://doi.org/10.1371/journal.pone.0096916" @default.
• W2018604414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4018399" @default.
• W2018604414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24819633" @default.
• W2018604414 hasPublicationYear "2014" @default.
• W2018604414 type Work @default.
• W2018604414 sameAs 2018604414 @default.
• W2018604414 citedByCount "29" @default.
• W2018604414 countsByYear W20186044142014 @default.
• W2018604414 countsByYear W20186044142015 @default.
• W2018604414 countsByYear W20186044142016 @default.
• W2018604414 countsByYear W20186044142017 @default.
• W2018604414 countsByYear W20186044142018 @default.
• W2018604414 countsByYear W20186044142019 @default.
• W2018604414 countsByYear W20186044142020 @default.
• W2018604414 countsByYear W20186044142021 @default.
• W2018604414 countsByYear W20186044142022 @default.
• W2018604414 countsByYear W20186044142023 @default.
• W2018604414 crossrefType "journal-article" @default.
• W2018604414 hasAuthorship W2018604414A5000309355 @default.
• W2018604414 hasAuthorship W2018604414A5010956554 @default.
• W2018604414 hasAuthorship W2018604414A5022075731 @default.
• W2018604414 hasAuthorship W2018604414A5038737554 @default.
• W2018604414 hasAuthorship W2018604414A5039339457 @default.
• W2018604414 hasAuthorship W2018604414A5041016069 @default.
• W2018604414 hasAuthorship W2018604414A5043088478 @default.
• W2018604414 hasAuthorship W2018604414A5057869899 @default.
• W2018604414 hasAuthorship W2018604414A5057920610 @default.
• W2018604414 hasBestOaLocation W20186044141 @default.
• W2018604414 hasConcept C126322002 @default.
• W2018604414 hasConcept C134018914 @default.
• W2018604414 hasConcept C159641895 @default.
• W2018604414 hasConcept C2775838275 @default.
• W2018604414 hasConcept C2776108821 @default.
• W2018604414 hasConcept C2776151105 @default.
• W2018604414 hasConcept C2777180221 @default.
• W2018604414 hasConcept C2778653478 @default.
• W2018604414 hasConcept C2779922275 @default.
• W2018604414 hasConcept C2781184683 @default.
• W2018604414 hasConcept C555293320 @default.
• W2018604414 hasConcept C71924100 @default.
• W2018604414 hasConceptScore W2018604414C126322002 @default.
• W2018604414 hasConceptScore W2018604414C134018914 @default.

• next