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- W2018605557 abstract "<h3>ABSTRACT</h3> We present the first high-resolution determination of transcriptome architecture in the priority pathogen <i>Acinetobacter baumannii</i>. Pooled RNA from 16 laboratory conditions was used for differential RNA-seq (dRNA-seq) to identify 3731 transcriptional start sites (TSS) and 110 small RNAs, including the first identification in <i>A. baumannii</i> of sRNAs encoded at the 3’ end of coding genes. Most sRNAs were conserved among sequenced <i>A. baumannii</i> genomes, but were only weakly conserved or absent in other <i>Acinetobacter</i> species. Single nucleotide mapping of TSS enabled prediction of −10 and −35 RNA polymerase binding sites and revealed an unprecedented base preference at position +2 that hints at an unrecognized transcriptional regulatory mechanism. To apply functional genomics to the problem of antimicrobial resistance, we dissected the transcriptional regulation of the drug efflux pump responsible for chloramphenicol resistance, <i>craA</i>. The two <i>craA</i> promoters were both down-regulated >1000-fold when cells were shifted to nutrient limited medium. This conditional down-regulation of <i>craA</i> expression renders cells sensitive to chloramphenicol, a highly effective antibiotic for the treatment of multidrug resistant infections. An online interface that facilitates open data access and visualization is provided as “AcinetoCom” (http://bioinf.gen.tcd.ie/acinetocom/)." @default.
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- W2018605557 title "Cerebral palsy and socioeconomic status: a retrospective cohort study" @default.
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- W2018605557 doi "https://doi.org/10.1136/adc.2002.018937" @default.
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