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- W2018609969 abstract "Retinoic acid inducible gene-I (RIG-I) is a caspase recruitment domain (CARD) containing protein that acts as an intracellular RNA receptor and senses virus infection. After binding to double stranded RNA (dsRNA) or 5′-triphosphate single stranded RNA (ssRNA), RIG-I transforms into an open conformation, translocates onto mitochondria, and interacts with the downstream adaptor mitochondrial antiviral signaling (MAVS) to induce the production of type I interferon and inflammatory factors via IRF3/7 and NF-κB pathways, respectively. Recently, accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events, such as inflammation and inflammation related diseases, cell proliferation, apoptosis and even senescence. Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields." @default.
- W2018609969 created "2016-06-24" @default.
- W2018609969 creator A5042238222 @default.
- W2018609969 creator A5060470951 @default.
- W2018609969 date "2011-05-01" @default.
- W2018609969 modified "2023-09-25" @default.
- W2018609969 title "Retinoic acid inducible gene-I, more than a virus sensor" @default.
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- W2018609969 doi "https://doi.org/10.1007/s13238-011-1045-y" @default.
- W2018609969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4875335" @default.
- W2018609969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21626268" @default.
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