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- W2018621056 endingPage "385" @default.
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- W2018621056 abstract "Bioisosteric replacement and scaffold hopping are twin methods used in drug design to improve the synthetic accessibility, potency and drug like properties of a compound and to move into novel chemical space. Bioisosteric replacement involves swapping functional groups of a molecule with other functional groups that have similar biological properties. Scaffold hopping is the replacement of the core framework of a molecule with another scaffold that will improve the properties of the molecule or to find similar potent compounds that exist in novel chemical space. This review outlines the key concepts, importance and challenges of both methods using examples and comparisons of techniques available for finding bioisosteric replacements and scaffold hops. There are many methods available for bioisosteric replacement and scaffold hopping, all with their own advantages and disadvantages. Drug design projects would benefit from a combination of these methods to retrieve diverse and complimentary results. Continuing progress in these fields will allow further validation of both methods as well as the accumulation of knowledge on bioisosteres and possible scaffold replacements." @default.
- W2018621056 created "2016-06-24" @default.
- W2018621056 creator A5025468315 @default.
- W2018621056 creator A5026586349 @default.
- W2018621056 creator A5072218846 @default.
- W2018621056 date "2010-05-05" @default.
- W2018621056 modified "2023-10-14" @default.
- W2018621056 title "Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization" @default.
- W2018621056 cites W1462940822 @default.
- W2018621056 cites W1507388445 @default.
- W2018621056 cites W1578639442 @default.
- W2018621056 cites W1595350250 @default.
- W2018621056 cites W1972155638 @default.
- W2018621056 cites W1978188288 @default.
- W2018621056 cites W1978644181 @default.
- W2018621056 cites W1979338194 @default.
- W2018621056 cites W1982727795 @default.
- W2018621056 cites W1983393839 @default.
- W2018621056 cites W1987027966 @default.
- W2018621056 cites W1987752375 @default.
- W2018621056 cites W1988883534 @default.
- W2018621056 cites W1990065809 @default.
- W2018621056 cites W1991262449 @default.
- W2018621056 cites W1991286793 @default.
- W2018621056 cites W1991621136 @default.
- W2018621056 cites W1992605554 @default.
- W2018621056 cites W1993452491 @default.
- W2018621056 cites W1997757562 @default.
- W2018621056 cites W1999025148 @default.
- W2018621056 cites W2007066266 @default.
- W2018621056 cites W2007910999 @default.
- W2018621056 cites W2009046773 @default.
- W2018621056 cites W2009707403 @default.
- W2018621056 cites W2012414836 @default.
- W2018621056 cites W2014540789 @default.
- W2018621056 cites W2015271090 @default.
- W2018621056 cites W2017189009 @default.
- W2018621056 cites W2019248806 @default.
- W2018621056 cites W2022125914 @default.
- W2018621056 cites W2026910177 @default.
- W2018621056 cites W2031082832 @default.
- W2018621056 cites W2031372687 @default.
- W2018621056 cites W2036893453 @default.
- W2018621056 cites W2037167896 @default.
- W2018621056 cites W2039472955 @default.
- W2018621056 cites W2039831563 @default.
- W2018621056 cites W2040426776 @default.
- W2018621056 cites W2042110087 @default.
- W2018621056 cites W2043204069 @default.
- W2018621056 cites W2048312836 @default.
- W2018621056 cites W2050451453 @default.
- W2018621056 cites W2052943632 @default.
- W2018621056 cites W2057350662 @default.
- W2018621056 cites W2058190282 @default.
- W2018621056 cites W2059556517 @default.
- W2018621056 cites W2060068498 @default.
- W2018621056 cites W2060531713 @default.
- W2018621056 cites W2061360855 @default.
- W2018621056 cites W2063021257 @default.
- W2018621056 cites W2064440950 @default.
- W2018621056 cites W2070505319 @default.
- W2018621056 cites W2074026532 @default.
- W2018621056 cites W2075186867 @default.
- W2018621056 cites W2075917770 @default.
- W2018621056 cites W2082670236 @default.
- W2018621056 cites W2085637483 @default.
- W2018621056 cites W2086632126 @default.
- W2018621056 cites W2087465523 @default.
- W2018621056 cites W2087952495 @default.
- W2018621056 cites W2092302310 @default.
- W2018621056 cites W2092325228 @default.
- W2018621056 cites W2093257291 @default.
- W2018621056 cites W2095103987 @default.
- W2018621056 cites W2096725584 @default.
- W2018621056 cites W2097475255 @default.
- W2018621056 cites W2100124621 @default.
- W2018621056 cites W2109885520 @default.
- W2018621056 cites W2116007667 @default.
- W2018621056 cites W2118958548 @default.
- W2018621056 cites W2125109129 @default.
- W2018621056 cites W2130958227 @default.
- W2018621056 cites W2146436588 @default.
- W2018621056 cites W2150155198 @default.
- W2018621056 cites W2155741020 @default.
- W2018621056 cites W2159822007 @default.
- W2018621056 cites W2160790360 @default.
- W2018621056 cites W2166478947 @default.
- W2018621056 cites W2167710978 @default.
- W2018621056 cites W2170966614 @default.
- W2018621056 cites W2179066627 @default.
- W2018621056 cites W2200017991 @default.
- W2018621056 cites W2203775767 @default.
- W2018621056 cites W2210141040 @default.
- W2018621056 cites W2214067381 @default.
- W2018621056 cites W2221103459 @default.
- W2018621056 cites W2317089277 @default.
- W2018621056 cites W2766040292 @default.
- W2018621056 cites W2951725785 @default.