FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018622408> ?p ?o ?g. }

• W2018622408 endingPage "185" @default.
• W2018622408 startingPage "181" @default.
• W2018622408 abstract "Aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 have been shown to play crucial roles in cartilage destruction in arthritic diseases, including rheumatoid arthritis and osteoarthritis. In this study, we examined the effects of nobiletin, a citrus polymethoxy flavone, on the expression and production of ADAMTS-4 and -5 in vitro and in vivo. Nobiletin (16-64muM) interfered with the interleukin (IL)-1beta-mediated ADAMTS-4 and -5 mRNA expression in cultured human synovial fibroblasts. Furthermore, intraperitoneal administration of nobiletin (15, 30, and 60mg/kg) also suppressed ADAMTS-4 and -5 mRNA expression in the joint tissues of collagen-induced arthritic (CIA) mice. Immunohistochemical analysis using an antibody against aggrecan neoepitope (NVTEGE(373)) revealed that aggrecanase-mediated degradation of aggrecan in cartilage was effectively inhibited by nobiletin. These results provide novel evidence that nobiletin effectively interferes with gene expression of ADAMTS-4 and -5, and thereby prevents cartilage destruction in CIA mice." @default.
• W2018622408 created "2016-06-24" @default.
• W2018622408 creator A5006113054 @default.
• W2018622408 creator A5016455326 @default.
• W2018622408 creator A5037837951 @default.
• W2018622408 creator A5045631892 @default.
• W2018622408 creator A5052308910 @default.
• W2018622408 creator A5052949240 @default.
• W2018622408 creator A5054832481 @default.
• W2018622408 creator A5070825498 @default.
• W2018622408 date "2008-08-01" @default.
• W2018622408 modified "2023-09-25" @default.
• W2018622408 title "Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice" @default.
• W2018622408 cites W1950911242 @default.
• W2018622408 cites W1972490124 @default.
• W2018622408 cites W1978635532 @default.
• W2018622408 cites W1984248230 @default.
• W2018622408 cites W1992837858 @default.
• W2018622408 cites W2027844006 @default.
• W2018622408 cites W2034919108 @default.
• W2018622408 cites W2048889862 @default.
• W2018622408 cites W2056522555 @default.
• W2018622408 cites W2075230292 @default.
• W2018622408 cites W2092494171 @default.
• W2018622408 cites W2101840353 @default.
• W2018622408 cites W2120146996 @default.
• W2018622408 cites W2120840387 @default.
• W2018622408 cites W2133032095 @default.
• W2018622408 cites W2135068351 @default.
• W2018622408 cites W2157234417 @default.
• W2018622408 cites W345774991 @default.
• W2018622408 doi "https://doi.org/10.1016/j.bbrc.2008.05.171" @default.
• W2018622408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18541144" @default.
• W2018622408 hasPublicationYear "2008" @default.
• W2018622408 type Work @default.
• W2018622408 sameAs 2018622408 @default.
• W2018622408 citedByCount "51" @default.
• W2018622408 countsByYear W20186224082012 @default.
• W2018622408 countsByYear W20186224082013 @default.
• W2018622408 countsByYear W20186224082014 @default.
• W2018622408 countsByYear W20186224082015 @default.
• W2018622408 countsByYear W20186224082016 @default.
• W2018622408 countsByYear W20186224082017 @default.
• W2018622408 countsByYear W20186224082019 @default.
• W2018622408 countsByYear W20186224082020 @default.
• W2018622408 countsByYear W20186224082021 @default.
• W2018622408 countsByYear W20186224082022 @default.
• W2018622408 countsByYear W20186224082023 @default.
• W2018622408 crossrefType "journal-article" @default.
• W2018622408 hasAuthorship W2018622408A5006113054 @default.
• W2018622408 hasAuthorship W2018622408A5016455326 @default.
• W2018622408 hasAuthorship W2018622408A5037837951 @default.
• W2018622408 hasAuthorship W2018622408A5045631892 @default.
• W2018622408 hasAuthorship W2018622408A5052308910 @default.
• W2018622408 hasAuthorship W2018622408A5052949240 @default.
• W2018622408 hasAuthorship W2018622408A5054832481 @default.
• W2018622408 hasAuthorship W2018622408A5070825498 @default.
• W2018622408 hasConcept C105702510 @default.
• W2018622408 hasConcept C109523444 @default.
• W2018622408 hasConcept C142724271 @default.
• W2018622408 hasConcept C153911025 @default.
• W2018622408 hasConcept C167814343 @default.
• W2018622408 hasConcept C185592680 @default.
• W2018622408 hasConcept C197534660 @default.
• W2018622408 hasConcept C204787440 @default.
• W2018622408 hasConcept C2776157581 @default.
• W2018622408 hasConcept C2776164576 @default.
• W2018622408 hasConcept C2776224515 @default.
• W2018622408 hasConcept C2778004101 @default.
• W2018622408 hasConcept C2778401301 @default.
• W2018622408 hasConcept C2779054382 @default.
• W2018622408 hasConcept C2780550940 @default.
• W2018622408 hasConcept C3020332539 @default.
• W2018622408 hasConcept C55493867 @default.
• W2018622408 hasConcept C55728118 @default.
• W2018622408 hasConcept C71924100 @default.
• W2018622408 hasConcept C86803240 @default.
• W2018622408 hasConcept C95444343 @default.
• W2018622408 hasConceptScore W2018622408C105702510 @default.
• W2018622408 hasConceptScore W2018622408C109523444 @default.
• W2018622408 hasConceptScore W2018622408C142724271 @default.
• W2018622408 hasConceptScore W2018622408C153911025 @default.
• W2018622408 hasConceptScore W2018622408C167814343 @default.
• W2018622408 hasConceptScore W2018622408C185592680 @default.
• W2018622408 hasConceptScore W2018622408C197534660 @default.
• W2018622408 hasConceptScore W2018622408C204787440 @default.
• W2018622408 hasConceptScore W2018622408C2776157581 @default.
• W2018622408 hasConceptScore W2018622408C2776164576 @default.
• W2018622408 hasConceptScore W2018622408C2776224515 @default.
• W2018622408 hasConceptScore W2018622408C2778004101 @default.
• W2018622408 hasConceptScore W2018622408C2778401301 @default.
• W2018622408 hasConceptScore W2018622408C2779054382 @default.
• W2018622408 hasConceptScore W2018622408C2780550940 @default.
• W2018622408 hasConceptScore W2018622408C3020332539 @default.
• W2018622408 hasConceptScore W2018622408C55493867 @default.
• W2018622408 hasConceptScore W2018622408C55728118 @default.
• W2018622408 hasConceptScore W2018622408C71924100 @default.
• W2018622408 hasConceptScore W2018622408C86803240 @default.

• next