FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018625136> ?p ?o ?g. }

• W2018625136 endingPage "69" @default.
• W2018625136 startingPage "63" @default.
• W2018625136 abstract "Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. We demonstrated previously that central nicotinic cholinergic receptors are involved in the pressor effect of histamine. The aim of the present study was to examine influences of centrally administrated histamine on acetylcholine (ACh) release at the posterior hypothalamus-a region characterized by location of histaminergic and cholinergic neurons involved in the regulation of the sympathetic activity in the cardiovascular system-in hemorrhage-hypotensive anesthetized rats. Hemodynamic and microdialysis studies were carried out in Sprague-Dawley rats. Hemorrhagic hypotension was induced by withdrawal of a volume of 1.5 ml blood/100 g body weight over a period of 10 min. Acute hemorrhage led to a severe and long-lasting decrease in mean arterial pressure (MAP), heart rate (HR), and an increase in extracellular posterior hypothalamic ACh and choline (Ch) levels by 56% and 59%, respectively. Intracerebroventricularly (i.c.v.) administered histamine (50, 100, and 200 nmol) dose- and time-dependently increased MAP and HR and caused an additional rise in extracellular posterior hypothalamic ACh and Ch levels at the most by 102%, as compared to the control saline-treated group. Histamine H1 receptor antagonist chlorpheniramine (50 nmol; i.c.v.) completely blocked histamine-evoked hemodynamic and extracellular posterior hypothalamic ACh and Ch changes, whereas H2 and H3/H4 receptor blockers ranitidine (50 nmol; i.c.v.) and thioperamide (50 nmol; i.c.v.) had no effect. In conclusion, centrally administered histamine, acting via H1 receptors, increases ACh release at the posterior hypothalamus and causes a pressor and tachycardic response in hemorrhage-hypotensive anesthetized rats." @default.
• W2018625136 created "2016-06-24" @default.
• W2018625136 creator A5035038056 @default.
• W2018625136 creator A5059546960 @default.
• W2018625136 creator A5085478605 @default.
• W2018625136 creator A5085600620 @default.
• W2018625136 creator A5085646604 @default.
• W2018625136 date "2015-01-01" @default.
• W2018625136 modified "2023-09-24" @default.
• W2018625136 title "Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats" @default.
• W2018625136 cites W1899272159 @default.
• W2018625136 cites W1978526355 @default.
• W2018625136 cites W1987130984 @default.
• W2018625136 cites W1987716765 @default.
• W2018625136 cites W1992585061 @default.
• W2018625136 cites W1992813376 @default.
• W2018625136 cites W1998388785 @default.
• W2018625136 cites W2001187100 @default.
• W2018625136 cites W2005829741 @default.
• W2018625136 cites W2013209485 @default.
• W2018625136 cites W2015056616 @default.
• W2018625136 cites W2015210497 @default.
• W2018625136 cites W2015885252 @default.
• W2018625136 cites W2016153068 @default.
• W2018625136 cites W2016610158 @default.
• W2018625136 cites W2019170656 @default.
• W2018625136 cites W2020814029 @default.
• W2018625136 cites W2022099467 @default.
• W2018625136 cites W2022823395 @default.
• W2018625136 cites W2030327444 @default.
• W2018625136 cites W2030369635 @default.
• W2018625136 cites W2033533136 @default.
• W2018625136 cites W2035327164 @default.
• W2018625136 cites W2042166970 @default.
• W2018625136 cites W2059762599 @default.
• W2018625136 cites W2060529309 @default.
• W2018625136 cites W2071823161 @default.
• W2018625136 cites W2092128425 @default.
• W2018625136 cites W2092882996 @default.
• W2018625136 cites W2094605937 @default.
• W2018625136 cites W2114808045 @default.
• W2018625136 cites W2124800180 @default.
• W2018625136 cites W2133436949 @default.
• W2018625136 cites W2325716920 @default.
• W2018625136 cites W282295870 @default.
• W2018625136 cites W4250786658 @default.
• W2018625136 doi "https://doi.org/10.1016/j.autneu.2014.11.004" @default.
• W2018625136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25468497" @default.
• W2018625136 hasPublicationYear "2015" @default.
• W2018625136 type Work @default.
• W2018625136 sameAs 2018625136 @default.
• W2018625136 citedByCount "15" @default.
• W2018625136 countsByYear W20186251362015 @default.
• W2018625136 countsByYear W20186251362016 @default.
• W2018625136 countsByYear W20186251362017 @default.
• W2018625136 countsByYear W20186251362018 @default.
• W2018625136 countsByYear W20186251362019 @default.
• W2018625136 countsByYear W20186251362021 @default.
• W2018625136 countsByYear W20186251362022 @default.
• W2018625136 crossrefType "journal-article" @default.
• W2018625136 hasAuthorship W2018625136A5035038056 @default.
• W2018625136 hasAuthorship W2018625136A5059546960 @default.
• W2018625136 hasAuthorship W2018625136A5085478605 @default.
• W2018625136 hasAuthorship W2018625136A5085600620 @default.
• W2018625136 hasAuthorship W2018625136A5085646604 @default.
• W2018625136 hasConcept C1122143 @default.
• W2018625136 hasConcept C126322002 @default.
• W2018625136 hasConcept C134018914 @default.
• W2018625136 hasConcept C170493617 @default.
• W2018625136 hasConcept C185592680 @default.
• W2018625136 hasConcept C22885893 @default.
• W2018625136 hasConcept C2775910092 @default.
• W2018625136 hasConcept C2776370428 @default.
• W2018625136 hasConcept C2776885963 @default.
• W2018625136 hasConcept C2778501154 @default.
• W2018625136 hasConcept C2778997900 @default.
• W2018625136 hasConcept C50156730 @default.
• W2018625136 hasConcept C529278444 @default.
• W2018625136 hasConcept C63180777 @default.
• W2018625136 hasConcept C71924100 @default.
• W2018625136 hasConceptScore W2018625136C1122143 @default.
• W2018625136 hasConceptScore W2018625136C126322002 @default.
• W2018625136 hasConceptScore W2018625136C134018914 @default.
• W2018625136 hasConceptScore W2018625136C170493617 @default.
• W2018625136 hasConceptScore W2018625136C185592680 @default.
• W2018625136 hasConceptScore W2018625136C22885893 @default.
• W2018625136 hasConceptScore W2018625136C2775910092 @default.
• W2018625136 hasConceptScore W2018625136C2776370428 @default.
• W2018625136 hasConceptScore W2018625136C2776885963 @default.
• W2018625136 hasConceptScore W2018625136C2778501154 @default.
• W2018625136 hasConceptScore W2018625136C2778997900 @default.
• W2018625136 hasConceptScore W2018625136C50156730 @default.
• W2018625136 hasConceptScore W2018625136C529278444 @default.
• W2018625136 hasConceptScore W2018625136C63180777 @default.
• W2018625136 hasConceptScore W2018625136C71924100 @default.
• W2018625136 hasLocation W20186251361 @default.
• W2018625136 hasLocation W20186251362 @default.
• W2018625136 hasOpenAccess W2018625136 @default.

• next