FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018626506> ?p ?o ?g. }

• W2018626506 endingPage "1434" @default.
• W2018626506 startingPage "1419" @default.
• W2018626506 abstract "Riboflavin synthase (RS) catalyzes the last step of riboflavin biosynthesis in microorganisms and plants, which corresponds to the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine to yield one molecule of riboflavin and one molecule of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione. Owing to the absence of this enzyme in animals and the fact that most pathogenic bacteria show a strict dependence on riboflavin biosynthesis, RS has been proposed as a potential target for antimicrobial drug development. Eubacterial, fungal and plant RSs assemble as homotrimers lacking C3 symmetry. Each monomer can bind two substrate molecules, yet there is only one active site for the whole enzyme, which is located at the interface between two neighbouring chains. This work reports the crystallographic structure of RS from the pathogenic bacterium Brucella abortus (the aetiological agent of the disease brucellosis) in its apo form, in complex with riboflavin and in complex with two different product analogues, being the first time that the structure of an intact RS trimer with bound ligands has been solved. These crystal models support the hypothesis of enhanced flexibility in the particle and also highlight the role of the ligands in assembling the unique active site. Kinetic and binding studies were also performed to complement these findings. The structural and biochemical information generated may be useful for the rational design of novel RS inhibitors with antimicrobial activity." @default.
• W2018626506 created "2016-06-24" @default.
• W2018626506 creator A5040549977 @default.
• W2018626506 creator A5045373023 @default.
• W2018626506 creator A5047482740 @default.
• W2018626506 creator A5061308652 @default.
• W2018626506 creator A5077686769 @default.
• W2018626506 creator A5089234644 @default.
• W2018626506 date "2014-04-30" @default.
• W2018626506 modified "2023-10-09" @default.
• W2018626506 title "Crystallographic and kinetic study of riboflavin synthase from<i>Brucella abortus</i>, a chemotherapeutic target with an enhanced intrinsic flexibility" @default.
• W2018626506 cites W1670177375 @default.
• W2018626506 cites W1966766357 @default.
• W2018626506 cites W1967517192 @default.
• W2018626506 cites W1973603811 @default.
• W2018626506 cites W1974449587 @default.
• W2018626506 cites W1975395286 @default.
• W2018626506 cites W1980532193 @default.
• W2018626506 cites W1988969394 @default.
• W2018626506 cites W1991659634 @default.
• W2018626506 cites W1992447641 @default.
• W2018626506 cites W2006128326 @default.
• W2018626506 cites W2012643496 @default.
• W2018626506 cites W2018678702 @default.
• W2018626506 cites W2023642165 @default.
• W2018626506 cites W2035503835 @default.
• W2018626506 cites W2042258122 @default.
• W2018626506 cites W2057741724 @default.
• W2018626506 cites W2065252029 @default.
• W2018626506 cites W2066950435 @default.
• W2018626506 cites W2067133614 @default.
• W2018626506 cites W2080476827 @default.
• W2018626506 cites W2080765791 @default.
• W2018626506 cites W2080875065 @default.
• W2018626506 cites W2082277228 @default.
• W2018626506 cites W2082637821 @default.
• W2018626506 cites W2085865075 @default.
• W2018626506 cites W2093815823 @default.
• W2018626506 cites W2103832206 @default.
• W2018626506 cites W2107412098 @default.
• W2018626506 cites W2108921801 @default.
• W2018626506 cites W2116275717 @default.
• W2018626506 cites W2124026197 @default.
• W2018626506 cites W2126865613 @default.
• W2018626506 cites W2137015675 @default.
• W2018626506 cites W2142635246 @default.
• W2018626506 cites W2144998676 @default.
• W2018626506 cites W2154714625 @default.
• W2018626506 cites W2156404282 @default.
• W2018626506 cites W2158660006 @default.
• W2018626506 cites W2159211495 @default.
• W2018626506 cites W2159407190 @default.
• W2018626506 cites W2159859043 @default.
• W2018626506 cites W2166071706 @default.
• W2018626506 cites W2166679810 @default.
• W2018626506 cites W2171881772 @default.
• W2018626506 cites W2172094400 @default.
• W2018626506 cites W2616645268 @default.
• W2018626506 cites W4210675630 @default.
• W2018626506 cites W4248872320 @default.
• W2018626506 cites W4248914259 @default.
• W2018626506 cites W4249530148 @default.
• W2018626506 doi "https://doi.org/10.1107/s1399004714005161" @default.
• W2018626506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014124" @default.
• W2018626506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24816110" @default.
• W2018626506 hasPublicationYear "2014" @default.
• W2018626506 type Work @default.
• W2018626506 sameAs 2018626506 @default.
• W2018626506 citedByCount "7" @default.
• W2018626506 countsByYear W20186265062018 @default.
• W2018626506 countsByYear W20186265062019 @default.
• W2018626506 countsByYear W20186265062021 @default.
• W2018626506 countsByYear W20186265062022 @default.
• W2018626506 countsByYear W20186265062023 @default.
• W2018626506 crossrefType "journal-article" @default.
• W2018626506 hasAuthorship W2018626506A5040549977 @default.
• W2018626506 hasAuthorship W2018626506A5045373023 @default.
• W2018626506 hasAuthorship W2018626506A5047482740 @default.
• W2018626506 hasAuthorship W2018626506A5061308652 @default.
• W2018626506 hasAuthorship W2018626506A5077686769 @default.
• W2018626506 hasAuthorship W2018626506A5089234644 @default.
• W2018626506 hasBestOaLocation W20186265062 @default.
• W2018626506 hasConcept C159110408 @default.
• W2018626506 hasConcept C161624437 @default.
• W2018626506 hasConcept C178790620 @default.
• W2018626506 hasConcept C181199279 @default.
• W2018626506 hasConcept C185592680 @default.
• W2018626506 hasConcept C2776155809 @default.
• W2018626506 hasConcept C32909587 @default.
• W2018626506 hasConcept C41183919 @default.
• W2018626506 hasConcept C41685203 @default.
• W2018626506 hasConcept C4937899 @default.
• W2018626506 hasConcept C553450214 @default.
• W2018626506 hasConcept C55493867 @default.
• W2018626506 hasConcept C71240020 @default.
• W2018626506 hasConcept C71924100 @default.
• W2018626506 hasConceptScore W2018626506C159110408 @default.
• W2018626506 hasConceptScore W2018626506C161624437 @default.

• next