FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018641079> ?p ?o ?g. }

• W2018641079 abstract "Currently, the approach most widely used to examine bone loss is the measurement of bone mineral density (BMD) using dual X-ray absorptiometry (DXA). However, bone loss due to immobilization creates changes in bone microarchitecture, which in turn are related to changes in bone mechanical function and competence to resist fracture.Unfortunately, the relationship between microarchitecture and mechanical function within the framework of immobilization and antiresorptive therapy has not being fully investigated. The goal of the present study was to investigate the structure–function relationship in trabecular bone in the real-world situations of a rapidly evolving osteoporosis(disuse), both with and without antiresorptive treatment. We evaluated the structure–function relationship in trabecular bone after bone loss (disuse-induced osteoporosis)and bisphosphonate treatment (antiresorptive therapy using risedronate) in canine trabecular bone using lCT and ultrasound wave propagation. Microstructure values determined from lCT images were used into the anisotropic poroelastic model of wave propagation in order to compute the apparent elastic constants (EC) and elastic anisotropy pattern of bone. Immobilization resulted in a significant reduction in trabecular thickness (Tb.Th) and bone volume fraction (BV/TV), while risedronate treatment combined with immobilization exhibited a lesser reduction in Tb.Th and BV/TV, suggesting that risedronate treatment decelerates bone loss, but it was unable to fully stop it. Risedronate treatment also increased the tissue mineral density (TMD), which when combined with the decrease in Tb.Th and BV/TV may explain the lack of significant differences invBMD in both immobilization and risedronate treated groups. Interestingly, changes inapparent EC were much stronger in the superior–inferior (SI) direction than in the medial–lateral (ML) and anterior–posterior (AP) anatomical directions, producing changes in elastic anisotropy patterns. When data were pooled together, vBMD was able to explain 58% of ultrasound measurements variability, a poroelastic wave propagation analytical model (i.e., BMD modulated by fabric directionality) was able to predict 81%of experimental wave velocity variability, and also explained 91% of apparent EC and changes in elastic anisotropy patterns. Overall, measurements of vBMD were unable to distinguish changes in apparent EC due to immobilization or risedronate treatment.However, anisotropic poroelastic ultrasound (PEUS) wave propagation was able to distinguish functional changes in apparent EC and elastic anisotropy patterns due to immobilization and antiresorptive therapy, providing an enhanced discrimination of anisotropic bone loss and the structure–function relationship in immobilized and risedronate-treated bone, beyond vBMD." @default.
• W2018641079 created "2016-06-24" @default.
• W2018641079 creator A5007331870 @default.
• W2018641079 creator A5040053224 @default.
• W2018641079 date "2015-01-01" @default.
• W2018641079 modified "2023-09-23" @default.
• W2018641079 title "Changes of Elastic Constants and Anisotropy Patterns in Trabecular Bone During Disuse-Induced Bone Loss Assessed by Poroelastic Ultrasound" @default.
• W2018641079 cites W1858494428 @default.
• W2018641079 cites W1966159686 @default.
• W2018641079 cites W1967282904 @default.
• W2018641079 cites W1974259943 @default.
• W2018641079 cites W1974395735 @default.
• W2018641079 cites W1983743846 @default.
• W2018641079 cites W1985926612 @default.
• W2018641079 cites W1996805530 @default.
• W2018641079 cites W2000175914 @default.
• W2018641079 cites W2000474073 @default.
• W2018641079 cites W2003508313 @default.
• W2018641079 cites W2005243630 @default.
• W2018641079 cites W2008093555 @default.
• W2018641079 cites W2009542232 @default.
• W2018641079 cites W2017773625 @default.
• W2018641079 cites W2019076654 @default.
• W2018641079 cites W2019693617 @default.
• W2018641079 cites W2020671611 @default.
• W2018641079 cites W2024746709 @default.
• W2018641079 cites W2025305988 @default.
• W2018641079 cites W2025456497 @default.
• W2018641079 cites W2026787913 @default.
• W2018641079 cites W2027037159 @default.
• W2018641079 cites W2028724000 @default.
• W2018641079 cites W2028816366 @default.
• W2018641079 cites W2032104202 @default.
• W2018641079 cites W2032316203 @default.
• W2018641079 cites W2040645421 @default.
• W2018641079 cites W2042695653 @default.
• W2018641079 cites W2043833615 @default.
• W2018641079 cites W2045253161 @default.
• W2018641079 cites W2046355103 @default.
• W2018641079 cites W2058201651 @default.
• W2018641079 cites W2066749771 @default.
• W2018641079 cites W2068442791 @default.
• W2018641079 cites W2073191780 @default.
• W2018641079 cites W2076266647 @default.
• W2018641079 cites W2076330525 @default.
• W2018641079 cites W2081573154 @default.
• W2018641079 cites W2082695083 @default.
• W2018641079 cites W2090642220 @default.
• W2018641079 cites W2101634616 @default.
• W2018641079 cites W2106966271 @default.
• W2018641079 cites W2115971863 @default.
• W2018641079 cites W2122061180 @default.
• W2018641079 cites W2125321976 @default.
• W2018641079 cites W2127210664 @default.
• W2018641079 cites W2135170100 @default.
• W2018641079 cites W2137579759 @default.
• W2018641079 cites W2142908537 @default.
• W2018641079 cites W2163917673 @default.
• W2018641079 cites W2170334103 @default.
• W2018641079 cites W2170424332 @default.
• W2018641079 cites W2276528930 @default.
• W2018641079 cites W2345394035 @default.
• W2018641079 cites W2412061207 @default.
• W2018641079 cites W2466728614 @default.
• W2018641079 cites W3101779966 @default.
• W2018641079 cites W348881265 @default.
• W2018641079 cites W4211160782 @default.
• W2018641079 doi "https://doi.org/10.1115/1.4029179" @default.
• W2018641079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4290507" @default.
• W2018641079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25412022" @default.
• W2018641079 hasPublicationYear "2015" @default.
• W2018641079 type Work @default.
• W2018641079 sameAs 2018641079 @default.
• W2018641079 citedByCount "4" @default.
• W2018641079 countsByYear W20186410792018 @default.
• W2018641079 countsByYear W20186410792019 @default.
• W2018641079 countsByYear W20186410792020 @default.
• W2018641079 crossrefType "journal-article" @default.
• W2018641079 hasAuthorship W2018641079A5007331870 @default.
• W2018641079 hasAuthorship W2018641079A5040053224 @default.
• W2018641079 hasBestOaLocation W20186410792 @default.
• W2018641079 hasConcept C105569014 @default.
• W2018641079 hasConcept C111335779 @default.
• W2018641079 hasConcept C126838900 @default.
• W2018641079 hasConcept C126894567 @default.
• W2018641079 hasConcept C134018914 @default.
• W2018641079 hasConcept C143753070 @default.
• W2018641079 hasConcept C159985019 @default.
• W2018641079 hasConcept C181965411 @default.
• W2018641079 hasConcept C192562407 @default.
• W2018641079 hasConcept C2524010 @default.
• W2018641079 hasConcept C2776541429 @default.
• W2018641079 hasConcept C2776886416 @default.
• W2018641079 hasConcept C2777251235 @default.
• W2018641079 hasConcept C2911223091 @default.
• W2018641079 hasConcept C33923547 @default.
• W2018641079 hasConcept C6648577 @default.
• W2018641079 hasConcept C673006 @default.
• W2018641079 hasConcept C71924100 @default.
• W2018641079 hasConceptScore W2018641079C105569014 @default.

• next