FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018642709> ?p ?o ?g. }

• W2018642709 endingPage "443" @default.
• W2018642709 startingPage "434" @default.
• W2018642709 abstract "The p38 MAP kinase inhibitor, SB 242235, was evaluated for its effects on the metabolism of bovine and human cartilage and primary chondrocyte cultures. SB 242235 had no effect on proteoglycan synthesis (PG) in bovine articular cartilage explants (BAC), as measured by [(35)S]-sulfate incorporation into glycosaminoglycans (GAGs). In addition, the compound had no effect on IL-1 alpha-induced GAG release from these cultures. However, there was a potent, dose-dependent inhibition of nitric oxide (NO) release from IL-1 alpha-stimulated BAC with an IC(50)of approximately 0.6 microM, with similar effects observed in primary chondrocytes. The effect on BAC was time dependent, and mechanistically did not appear to be the result of inhibition of protein kinase C (PKC), protein kinase A (PKA) or MEK-1. The effect on NO release in bovine chondrocytes was at the level of inducible nitric oxide synthase (iNOS) gene expression, which was inhibited at similar concentrations as nitrite production. In primary human chondrocytes, IL-1 beta induction of p38 MAP kinase was inhibited by SB 242235 with an IC(50)of approximately 1 microM. Surprisingly, however, treatment of IL-beta-stimulated human cartilage or chondrocytes with SB 242235 did not inhibit either NO production or the induction of iNOS. On the other hand, the natural product hymenialdisine (HYM), a protein tyrosine kinase (PTK) inhibitor, inhibited NO production and iNOS in both species. In contrast to the differential control of iNOS, PGE(2)was inhibited by SB 242235 in both IL-1-stimulated bovine and human chondrocyte cultures. These studies indicate that there are species differences in the control of iNOS by p38 inhibitors and also that different pathways may control IL-1-induced proteoglycan breakdown and NO production." @default.
• W2018642709 created "2016-06-24" @default.
• W2018642709 creator A5013116316 @default.
• W2018642709 creator A5019335559 @default.
• W2018642709 creator A5027461408 @default.
• W2018642709 creator A5036349622 @default.
• W2018642709 creator A5038338413 @default.
• W2018642709 creator A5041317341 @default.
• W2018642709 creator A5050948761 @default.
• W2018642709 creator A5054879837 @default.
• W2018642709 creator A5065451393 @default.
• W2018642709 creator A5070870574 @default.
• W2018642709 creator A5078659062 @default.
• W2018642709 date "2000-11-01" @default.
• W2018642709 modified "2023-10-06" @default.
• W2018642709 title "Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures" @default.
• W2018642709 cites W1491342058 @default.
• W2018642709 cites W1533808086 @default.
• W2018642709 cites W1572176725 @default.
• W2018642709 cites W1660988713 @default.
• W2018642709 cites W1915946375 @default.
• W2018642709 cites W1927941125 @default.
• W2018642709 cites W1972338749 @default.
• W2018642709 cites W1973766879 @default.
• W2018642709 cites W1976005750 @default.
• W2018642709 cites W1976462601 @default.
• W2018642709 cites W1980831535 @default.
• W2018642709 cites W1984344092 @default.
• W2018642709 cites W1985888026 @default.
• W2018642709 cites W1990802251 @default.
• W2018642709 cites W1991040567 @default.
• W2018642709 cites W1996542645 @default.
• W2018642709 cites W1998019270 @default.
• W2018642709 cites W2001399809 @default.
• W2018642709 cites W2010018399 @default.
• W2018642709 cites W2016687652 @default.
• W2018642709 cites W2018961569 @default.
• W2018642709 cites W2024191096 @default.
• W2018642709 cites W2025166922 @default.
• W2018642709 cites W2032731042 @default.
• W2018642709 cites W2033077711 @default.
• W2018642709 cites W2033123803 @default.
• W2018642709 cites W2038170564 @default.
• W2018642709 cites W2048383047 @default.
• W2018642709 cites W2057635936 @default.
• W2018642709 cites W2063580118 @default.
• W2018642709 cites W2080801901 @default.
• W2018642709 cites W2084365684 @default.
• W2018642709 cites W2092867618 @default.
• W2018642709 cites W2093195099 @default.
• W2018642709 cites W2105367621 @default.
• W2018642709 cites W2115021310 @default.
• W2018642709 cites W2116450468 @default.
• W2018642709 cites W2119887587 @default.
• W2018642709 cites W2120005533 @default.
• W2018642709 cites W2124962639 @default.
• W2018642709 cites W2125345402 @default.
• W2018642709 cites W2131177227 @default.
• W2018642709 cites W2131369444 @default.
• W2018642709 cites W2152685208 @default.
• W2018642709 cites W2167869180 @default.
• W2018642709 cites W2335815491 @default.
• W2018642709 cites W2341881834 @default.
• W2018642709 cites W4313333801 @default.
• W2018642709 doi "https://doi.org/10.1053/joca.1999.0319" @default.
• W2018642709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11069728" @default.
• W2018642709 hasPublicationYear "2000" @default.
• W2018642709 type Work @default.
• W2018642709 sameAs 2018642709 @default.
• W2018642709 citedByCount "47" @default.
• W2018642709 countsByYear W20186427092012 @default.
• W2018642709 countsByYear W20186427092013 @default.
• W2018642709 countsByYear W20186427092015 @default.
• W2018642709 countsByYear W20186427092016 @default.
• W2018642709 countsByYear W20186427092017 @default.
• W2018642709 countsByYear W20186427092021 @default.
• W2018642709 countsByYear W20186427092022 @default.
• W2018642709 countsByYear W20186427092023 @default.
• W2018642709 crossrefType "journal-article" @default.
• W2018642709 hasAuthorship W2018642709A5013116316 @default.
• W2018642709 hasAuthorship W2018642709A5019335559 @default.
• W2018642709 hasAuthorship W2018642709A5027461408 @default.
• W2018642709 hasAuthorship W2018642709A5036349622 @default.
• W2018642709 hasAuthorship W2018642709A5038338413 @default.
• W2018642709 hasAuthorship W2018642709A5041317341 @default.
• W2018642709 hasAuthorship W2018642709A5050948761 @default.
• W2018642709 hasAuthorship W2018642709A5054879837 @default.
• W2018642709 hasAuthorship W2018642709A5065451393 @default.
• W2018642709 hasAuthorship W2018642709A5070870574 @default.
• W2018642709 hasAuthorship W2018642709A5078659062 @default.
• W2018642709 hasBestOaLocation W20186427091 @default.
• W2018642709 hasConcept C105702510 @default.
• W2018642709 hasConcept C153074725 @default.
• W2018642709 hasConcept C153911025 @default.
• W2018642709 hasConcept C178790620 @default.
• W2018642709 hasConcept C184235292 @default.
• W2018642709 hasConcept C185592680 @default.
• W2018642709 hasConcept C195794163 @default.

• next