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• W2018643453 startingPage "4522" @default.
• W2018643453 abstract "Interaction of the alpha beta T cell receptor (TCR) with major histocompatibility (MHC) molecules occupied with any of a large collection of peptides derived from self proteins is a critical step in driving T cell positive selection in the thymus. Interaction with this same pool of self-peptide/MHC ligands deletes T cells with potential self-reactivity. To examine how T cells survive both of these processes to form a self-tolerant mature repertoire, mice were constructed whose entire class II MHC IEk specific repertoire was positively selected on a single peptide covalently attached to the IEk molecule. In these mice T cells were identified that could respond to a variant of the positively selecting peptide bound to IEk. The affinities of the TCRs from these T cells for the positively selecting ligand were extremely low and at least 10-fold less than those for the activating ligand. These results support the theory that positive selection is driven by TCR affinities lower than those involved in T cell deletion or activation and that, if present at high concentration, even very low affinity ligands can positively select." @default.
• W2018643453 created "2016-06-24" @default.
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• W2018643453 date "1998-04-14" @default.
• W2018643453 modified "2023-09-27" @default.
• W2018643453 title "T cell positive selection by a high density, low affinity ligand" @default.
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• W2018643453 doi "https://doi.org/10.1073/pnas.95.8.4522" @default.
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