Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018644522> ?p ?o ?g. }
- W2018644522 endingPage "96" @default.
- W2018644522 startingPage "71" @default.
- W2018644522 abstract "DNA replication is a primary mechanism for maintaining genome integrity, but it serves this purpose best by cooperating with other proteins involved in DNA repair and recombination. Unlike leading strand synthesis, lagging strand synthesis has a greater risk of faulty replication for several reasons: First, a significant part of DNA is synthesized by polymerase alpha, which lacks a proofreading function. Second, a great number of Okazaki fragments are synthesized, processed and ligated per cell division. Third, the principal mechanism of Okazaki fragment processing is via generation of flaps, which have the potential to form a variety of structures in their sequence context. Finally, many proteins for the lagging strand interact with factors involved in repair and recombination. Thus, lagging strand DNA synthesis could be the best example of a converging place of both replication and repair proteins. To achieve the risky task with extraordinary fidelity, Okazaki fragment processing may depend on multiple layers of redundant, but connected pathways. An essential Dna2 endonuclease/helicase plays a pivotal role in processing common structural intermediates that occur during diverse DNA metabolisms (e.g. lagging strand synthesis and telomere maintenance). Many roles of Dna2 suggest that the preemptive removal of long or structured flaps ultimately contributes to genome maintenance in eukaryotes. In this review, we describe the function of Dna2 in Okazaki fragment processing, and discuss its role in the maintenance of genome integrity with an emphasis on its functional interactions with other factors required for genome maintenance." @default.
- W2018644522 created "2016-06-24" @default.
- W2018644522 creator A5004143966 @default.
- W2018644522 creator A5027717102 @default.
- W2018644522 creator A5039796941 @default.
- W2018644522 date "2010-02-04" @default.
- W2018644522 modified "2023-10-10" @default.
- W2018644522 title "Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes" @default.
- W2018644522 cites W1490159978 @default.
- W2018644522 cites W1496127239 @default.
- W2018644522 cites W1506492200 @default.
- W2018644522 cites W1550656265 @default.
- W2018644522 cites W1559981481 @default.
- W2018644522 cites W1566131689 @default.
- W2018644522 cites W1573865605 @default.
- W2018644522 cites W161351823 @default.
- W2018644522 cites W1642366110 @default.
- W2018644522 cites W1683995796 @default.
- W2018644522 cites W1729887059 @default.
- W2018644522 cites W1754682352 @default.
- W2018644522 cites W1774053018 @default.
- W2018644522 cites W1901832225 @default.
- W2018644522 cites W1922687004 @default.
- W2018644522 cites W1944079546 @default.
- W2018644522 cites W1948260762 @default.
- W2018644522 cites W1964699435 @default.
- W2018644522 cites W1965573008 @default.
- W2018644522 cites W1966219094 @default.
- W2018644522 cites W1966464105 @default.
- W2018644522 cites W1967779036 @default.
- W2018644522 cites W1969003098 @default.
- W2018644522 cites W1969459765 @default.
- W2018644522 cites W1972746487 @default.
- W2018644522 cites W1973535211 @default.
- W2018644522 cites W1981447455 @default.
- W2018644522 cites W1982041480 @default.
- W2018644522 cites W1982647833 @default.
- W2018644522 cites W1983441569 @default.
- W2018644522 cites W1986435856 @default.
- W2018644522 cites W1988134095 @default.
- W2018644522 cites W1990299164 @default.
- W2018644522 cites W1993026474 @default.
- W2018644522 cites W1994495961 @default.
- W2018644522 cites W1994552302 @default.
- W2018644522 cites W1994569839 @default.
- W2018644522 cites W1996783278 @default.
- W2018644522 cites W1997002747 @default.
- W2018644522 cites W1997909925 @default.
- W2018644522 cites W2001231205 @default.
- W2018644522 cites W2003329456 @default.
- W2018644522 cites W2003847336 @default.
- W2018644522 cites W2003885077 @default.
- W2018644522 cites W2003902368 @default.
- W2018644522 cites W2004008931 @default.
- W2018644522 cites W2004099247 @default.
- W2018644522 cites W2006220727 @default.
- W2018644522 cites W2006538713 @default.
- W2018644522 cites W2009167909 @default.
- W2018644522 cites W2010302368 @default.
- W2018644522 cites W2010544809 @default.
- W2018644522 cites W2010711320 @default.
- W2018644522 cites W2014223000 @default.
- W2018644522 cites W2015631455 @default.
- W2018644522 cites W2016357039 @default.
- W2018644522 cites W2016520126 @default.
- W2018644522 cites W2017146141 @default.
- W2018644522 cites W2017285840 @default.
- W2018644522 cites W2017782528 @default.
- W2018644522 cites W2018284593 @default.
- W2018644522 cites W2019068162 @default.
- W2018644522 cites W2019197460 @default.
- W2018644522 cites W2019404529 @default.
- W2018644522 cites W2020390201 @default.
- W2018644522 cites W2021084223 @default.
- W2018644522 cites W2021345772 @default.
- W2018644522 cites W2021483139 @default.
- W2018644522 cites W2021889880 @default.
- W2018644522 cites W2022524226 @default.
- W2018644522 cites W2027532032 @default.
- W2018644522 cites W2028774533 @default.
- W2018644522 cites W2029146269 @default.
- W2018644522 cites W2029440030 @default.
- W2018644522 cites W2033240783 @default.
- W2018644522 cites W2033676950 @default.
- W2018644522 cites W2034535098 @default.
- W2018644522 cites W2035561771 @default.
- W2018644522 cites W2035746057 @default.
- W2018644522 cites W2038336865 @default.
- W2018644522 cites W2038477871 @default.
- W2018644522 cites W2038529419 @default.
- W2018644522 cites W2039653473 @default.
- W2018644522 cites W2040167235 @default.
- W2018644522 cites W2040392790 @default.
- W2018644522 cites W2041945142 @default.
- W2018644522 cites W2043577829 @default.
- W2018644522 cites W2045069136 @default.
- W2018644522 cites W2046356778 @default.
- W2018644522 cites W2048650842 @default.