FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018647053> ?p ?o ?g. }

• W2018647053 endingPage "782" @default.
• W2018647053 startingPage "773" @default.
• W2018647053 abstract "ObjectivePost-traumatic osteoarthritis (PTOA) is a common consequence of traumatic joint injury, with 50% of anterior cruciate ligament (ACL) rupture patients developing PTOA within 10–20 years. Currently accepted mouse models of PTOA initiate symptoms using various methods, none of which faithfully mimic clinically-relevant injury conditions. In this study we characterize a novel non-invasive mouse model of PTOA that injures the ACL with a single load of tibial compression overload. We utilize this model to determine the time course of articular cartilage and subchondral bone changes following knee injury.DesignMice were euthanized 1, 3, 7, 14, 28, or 56 days after non-invasive knee injury. Knees were scanned using micro-computed tomography (μCT) in order to quantify subchondral trabecular bone, subchondral bone plate, and non-native bone formation (heterotopic ossification). Development of osteoarthritis (OA) was graded using the osteoarthritis research society international (OARSI) scale on histological sections of injured and uninjured knees.ResultsFollowing injury we observed a rapid loss of trabecular bone in injured knees compared to uninjured knees by 7 days post-injury, followed by a partial recovery of trabecular bone to a new steady state by 28 days post-injury. We also observed considerable non-native bone formation by 56 days post-injury. Grading of histological sections revealed deterioration of articular cartilage by 56 days post-injury, consistent with development of mild OA.ConclusionsThis study establishes a novel mouse model of PTOA, and describes the time course of musculoskeletal changes following knee injury, helping to establish the window of opportunity for preventative treatment. Post-traumatic osteoarthritis (PTOA) is a common consequence of traumatic joint injury, with 50% of anterior cruciate ligament (ACL) rupture patients developing PTOA within 10–20 years. Currently accepted mouse models of PTOA initiate symptoms using various methods, none of which faithfully mimic clinically-relevant injury conditions. In this study we characterize a novel non-invasive mouse model of PTOA that injures the ACL with a single load of tibial compression overload. We utilize this model to determine the time course of articular cartilage and subchondral bone changes following knee injury. Mice were euthanized 1, 3, 7, 14, 28, or 56 days after non-invasive knee injury. Knees were scanned using micro-computed tomography (μCT) in order to quantify subchondral trabecular bone, subchondral bone plate, and non-native bone formation (heterotopic ossification). Development of osteoarthritis (OA) was graded using the osteoarthritis research society international (OARSI) scale on histological sections of injured and uninjured knees. Following injury we observed a rapid loss of trabecular bone in injured knees compared to uninjured knees by 7 days post-injury, followed by a partial recovery of trabecular bone to a new steady state by 28 days post-injury. We also observed considerable non-native bone formation by 56 days post-injury. Grading of histological sections revealed deterioration of articular cartilage by 56 days post-injury, consistent with development of mild OA. This study establishes a novel mouse model of PTOA, and describes the time course of musculoskeletal changes following knee injury, helping to establish the window of opportunity for preventative treatment." @default.
• W2018647053 created "2016-06-24" @default.
• W2018647053 creator A5022082036 @default.
• W2018647053 creator A5029704717 @default.
• W2018647053 creator A5032448354 @default.
• W2018647053 creator A5066596486 @default.
• W2018647053 creator A5071065759 @default.
• W2018647053 creator A5073670709 @default.
• W2018647053 date "2012-07-01" @default.
• W2018647053 modified "2023-10-16" @default.
• W2018647053 title "Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis" @default.
• W2018647053 cites W1977765236 @default.
• W2018647053 cites W1978107016 @default.
• W2018647053 cites W1985842679 @default.
• W2018647053 cites W2002251686 @default.
• W2018647053 cites W2011227409 @default.
• W2018647053 cites W2025398368 @default.
• W2018647053 cites W2028920679 @default.
• W2018647053 cites W2032716638 @default.
• W2018647053 cites W2054729774 @default.
• W2018647053 cites W2057231343 @default.
• W2018647053 cites W2066749771 @default.
• W2018647053 cites W2068063049 @default.
• W2018647053 cites W2078910654 @default.
• W2018647053 cites W2079010022 @default.
• W2018647053 cites W2110901553 @default.
• W2018647053 cites W2118963985 @default.
• W2018647053 cites W2139762892 @default.
• W2018647053 cites W2143461769 @default.
• W2018647053 cites W2157231484 @default.
• W2018647053 cites W4232024554 @default.
• W2018647053 cites W4243694479 @default.
• W2018647053 cites W4322702225 @default.
• W2018647053 doi "https://doi.org/10.1016/j.joca.2012.04.014" @default.
• W2018647053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22531459" @default.
• W2018647053 hasPublicationYear "2012" @default.
• W2018647053 type Work @default.
• W2018647053 sameAs 2018647053 @default.
• W2018647053 citedByCount "168" @default.
• W2018647053 countsByYear W20186470532013 @default.
• W2018647053 countsByYear W20186470532014 @default.
• W2018647053 countsByYear W20186470532015 @default.
• W2018647053 countsByYear W20186470532016 @default.
• W2018647053 countsByYear W20186470532017 @default.
• W2018647053 countsByYear W20186470532018 @default.
• W2018647053 countsByYear W20186470532019 @default.
• W2018647053 countsByYear W20186470532020 @default.
• W2018647053 countsByYear W20186470532021 @default.
• W2018647053 countsByYear W20186470532022 @default.
• W2018647053 countsByYear W20186470532023 @default.
• W2018647053 crossrefType "journal-article" @default.
• W2018647053 hasAuthorship W2018647053A5022082036 @default.
• W2018647053 hasAuthorship W2018647053A5029704717 @default.
• W2018647053 hasAuthorship W2018647053A5032448354 @default.
• W2018647053 hasAuthorship W2018647053A5066596486 @default.
• W2018647053 hasAuthorship W2018647053A5071065759 @default.
• W2018647053 hasAuthorship W2018647053A5073670709 @default.
• W2018647053 hasBestOaLocation W20186470531 @default.
• W2018647053 hasConcept C105702510 @default.
• W2018647053 hasConcept C141071460 @default.
• W2018647053 hasConcept C142724271 @default.
• W2018647053 hasConcept C204787440 @default.
• W2018647053 hasConcept C2776164576 @default.
• W2018647053 hasConcept C2778434673 @default.
• W2018647053 hasConcept C2780550940 @default.
• W2018647053 hasConcept C2780650075 @default.
• W2018647053 hasConcept C2781032047 @default.
• W2018647053 hasConcept C2781170992 @default.
• W2018647053 hasConcept C2908736133 @default.
• W2018647053 hasConcept C3018615303 @default.
• W2018647053 hasConcept C3020332539 @default.
• W2018647053 hasConcept C71924100 @default.
• W2018647053 hasConceptScore W2018647053C105702510 @default.
• W2018647053 hasConceptScore W2018647053C141071460 @default.
• W2018647053 hasConceptScore W2018647053C142724271 @default.
• W2018647053 hasConceptScore W2018647053C204787440 @default.
• W2018647053 hasConceptScore W2018647053C2776164576 @default.
• W2018647053 hasConceptScore W2018647053C2778434673 @default.
• W2018647053 hasConceptScore W2018647053C2780550940 @default.
• W2018647053 hasConceptScore W2018647053C2780650075 @default.
• W2018647053 hasConceptScore W2018647053C2781032047 @default.
• W2018647053 hasConceptScore W2018647053C2781170992 @default.
• W2018647053 hasConceptScore W2018647053C2908736133 @default.
• W2018647053 hasConceptScore W2018647053C3018615303 @default.
• W2018647053 hasConceptScore W2018647053C3020332539 @default.
• W2018647053 hasConceptScore W2018647053C71924100 @default.
• W2018647053 hasIssue "7" @default.
• W2018647053 hasLocation W20186470531 @default.
• W2018647053 hasLocation W20186470532 @default.
• W2018647053 hasOpenAccess W2018647053 @default.
• W2018647053 hasPrimaryLocation W20186470531 @default.
• W2018647053 hasRelatedWork W1974970489 @default.
• W2018647053 hasRelatedWork W2018647053 @default.
• W2018647053 hasRelatedWork W2091383881 @default.
• W2018647053 hasRelatedWork W2461893715 @default.
• W2018647053 hasRelatedWork W2519009268 @default.
• W2018647053 hasRelatedWork W2919612068 @default.
• W2018647053 hasRelatedWork W3016889489 @default.

• next