FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018647429> ?p ?o ?g. }

• W2018647429 endingPage "e236" @default.
• W2018647429 startingPage "e236" @default.
• W2018647429 abstract "Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. However, the molecular mechanisms regulating these signaling pathways are not fully understood. Here, we describe the regulation of bone morphogenic protein (BMP) signaling by Bat3 (also known as Scythe or BAG6). Bat3 overexpression in murine cell lines suppresses the activity of the Id1 promoter normally induced by BMP signaling. Conversely, Bat3 inactivation enhances the induction of direct BMP target genes, such as Id1, Smad6, and Smad7. Consequently, Bat3 deficiency accelerates the differentiation of primary osteoblasts into bone, with a concomitant increase in the bone differentiation markers Runx2, Osterix, and alkaline phosphatase. Using biochemical and cell biological analyses, we show that Bat3 inactivation sustains the C-terminal phosphorylation and nuclear localization of Smad1, 5, and 8 (Smad1/5/8), thereby enhancing biological responses to BMP treatment. At the mechanistic level, we show that Bat3 interacts with the nuclear phosphatase small C-terminal domain phosphatase (SCP) 2, which terminates BMP signaling by dephosphorylating Smad1/5/8. Notably, Bat3 enhances SCP2-Smad1 interaction only when the BMP signaling pathway is activated. Our results demonstrate that Bat3 is an important regulator of BMP signaling that functions by modulating SCP2-Smad interaction." @default.
• W2018647429 created "2016-06-24" @default.
• W2018647429 creator A5033939754 @default.
• W2018647429 creator A5035229281 @default.
• W2018647429 creator A5067952063 @default.
• W2018647429 creator A5069440644 @default.
• W2018647429 date "2011-12-01" @default.
• W2018647429 modified "2023-10-14" @default.
• W2018647429 title "HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling" @default.
• W2018647429 cites W1657005131 @default.
• W2018647429 cites W1968075576 @default.
• W2018647429 cites W1976454147 @default.
• W2018647429 cites W1982737034 @default.
• W2018647429 cites W1982757612 @default.
• W2018647429 cites W2017145792 @default.
• W2018647429 cites W2019848334 @default.
• W2018647429 cites W2020348993 @default.
• W2018647429 cites W2028070445 @default.
• W2018647429 cites W2034779933 @default.
• W2018647429 cites W2040194330 @default.
• W2018647429 cites W2042074752 @default.
• W2018647429 cites W2051190668 @default.
• W2018647429 cites W2075051169 @default.
• W2018647429 cites W2076305288 @default.
• W2018647429 cites W2076329388 @default.
• W2018647429 cites W2077243151 @default.
• W2018647429 cites W2080435694 @default.
• W2018647429 cites W2084414513 @default.
• W2018647429 cites W2088559146 @default.
• W2018647429 cites W2091756716 @default.
• W2018647429 cites W2091797313 @default.
• W2018647429 cites W2094298405 @default.
• W2018647429 cites W2098183783 @default.
• W2018647429 cites W2111786431 @default.
• W2018647429 cites W2112647530 @default.
• W2018647429 cites W2117200840 @default.
• W2018647429 cites W2121594380 @default.
• W2018647429 cites W2128484344 @default.
• W2018647429 cites W2130076355 @default.
• W2018647429 cites W2130766755 @default.
• W2018647429 cites W2136280424 @default.
• W2018647429 cites W2141860100 @default.
• W2018647429 cites W2146191765 @default.
• W2018647429 cites W2147420663 @default.
• W2018647429 cites W2155548828 @default.
• W2018647429 cites W2157710443 @default.
• W2018647429 cites W2161357967 @default.
• W2018647429 cites W2163018106 @default.
• W2018647429 cites W2190725551 @default.
• W2018647429 doi "https://doi.org/10.1038/cddis.2011.114" @default.
• W2018647429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3252739" @default.
• W2018647429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22130070" @default.
• W2018647429 hasPublicationYear "2011" @default.
• W2018647429 type Work @default.
• W2018647429 sameAs 2018647429 @default.
• W2018647429 citedByCount "7" @default.
• W2018647429 countsByYear W20186474292012 @default.
• W2018647429 countsByYear W20186474292016 @default.
• W2018647429 countsByYear W20186474292018 @default.
• W2018647429 countsByYear W20186474292020 @default.
• W2018647429 countsByYear W20186474292021 @default.
• W2018647429 crossrefType "journal-article" @default.
• W2018647429 hasAuthorship W2018647429A5033939754 @default.
• W2018647429 hasAuthorship W2018647429A5035229281 @default.
• W2018647429 hasAuthorship W2018647429A5067952063 @default.
• W2018647429 hasAuthorship W2018647429A5069440644 @default.
• W2018647429 hasBestOaLocation W20186474291 @default.
• W2018647429 hasConcept C104317684 @default.
• W2018647429 hasConcept C11960822 @default.
• W2018647429 hasConcept C2781080636 @default.
• W2018647429 hasConcept C31507581 @default.
• W2018647429 hasConcept C54355233 @default.
• W2018647429 hasConcept C62478195 @default.
• W2018647429 hasConcept C86803240 @default.
• W2018647429 hasConcept C95444343 @default.
• W2018647429 hasConceptScore W2018647429C104317684 @default.
• W2018647429 hasConceptScore W2018647429C11960822 @default.
• W2018647429 hasConceptScore W2018647429C2781080636 @default.
• W2018647429 hasConceptScore W2018647429C31507581 @default.
• W2018647429 hasConceptScore W2018647429C54355233 @default.
• W2018647429 hasConceptScore W2018647429C62478195 @default.
• W2018647429 hasConceptScore W2018647429C86803240 @default.
• W2018647429 hasConceptScore W2018647429C95444343 @default.
• W2018647429 hasIssue "12" @default.
• W2018647429 hasLocation W20186474291 @default.
• W2018647429 hasLocation W20186474292 @default.
• W2018647429 hasLocation W20186474293 @default.
• W2018647429 hasLocation W20186474294 @default.
• W2018647429 hasOpenAccess W2018647429 @default.
• W2018647429 hasPrimaryLocation W20186474291 @default.
• W2018647429 hasRelatedWork W1521595843 @default.
• W2018647429 hasRelatedWork W1558754969 @default.
• W2018647429 hasRelatedWork W2005440804 @default.
• W2018647429 hasRelatedWork W2071002222 @default.
• W2018647429 hasRelatedWork W2093271566 @default.
• W2018647429 hasRelatedWork W2112903125 @default.
• W2018647429 hasRelatedWork W2352788820 @default.
• W2018647429 hasRelatedWork W2358123883 @default.

• next