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• W2018649613 endingPage "524" @default.
• W2018649613 startingPage "509" @default.
• W2018649613 abstract "While clinical studies show maternal consumption of palatable fat-rich diets during pregnancy to negatively impact the children’s behaviors and increase their vulnerability to drug abuse, the precise behavioral and neurochemical mechanisms mediating these phenomena have yet to be examined. The study examined in rats whether gestational exposure to a high-fat diet (HFD) can increase the offspring’s propensity to use nicotine and whether disturbances in central nicotinic cholinergic signaling accompany this behavioral effect. Rat offspring exposed perinatally to a HFD or chow diet were characterized in terms of their nicotine self-administration behavior in a series of operant response experiments and the activity of acetylcholinesterase (AChE) and density of nicotinic ACh receptors (nAChRs) in different brain areas. Perinatal HFD compared to chow exposure increased nicotine-self administration behavior during fixed ratio and dose–response testing and caused an increase in breakpoint using progressive ratio testing, while nicotine seeking in response to nicotine prime-induced reinstatement was reduced. This behavioral change induced by the HFD was associated with a significant reduction in activity of AChE in the midbrain, hypothalamus, and striatum and increased density of β2-nAChRs in the ventral tegmental area and substantia nigra and of α7-nAChRs in the lateral and ventromedial hypothalamus. Perinatal exposure to a HFD increases the vulnerability of the offspring to excessive nicotine use by enhancing its reward potential, and these behavioral changes are accompanied by a stimulation of nicotinic cholinergic signaling in mesostriatal and hypothalamic brain areas important for reinforcement and consummatory behavior." @default.
• W2018649613 created "2016-06-24" @default.
• W2018649613 creator A5008041769 @default.
• W2018649613 creator A5028898765 @default.
• W2018649613 creator A5055944768 @default.
• W2018649613 creator A5075462630 @default.
• W2018649613 creator A5082982173 @default.
• W2018649613 creator A5084900431 @default.
• W2018649613 creator A5090507281 @default.
• W2018649613 date "2013-07-09" @default.
• W2018649613 modified "2023-10-06" @default.
• W2018649613 title "Stimulation of nicotine reward and central cholinergic activity in Sprague–Dawley rats exposed perinatally to a fat-rich diet" @default.
• W2018649613 cites W1485185596 @default.
• W2018649613 cites W1557320868 @default.
• W2018649613 cites W1562859000 @default.
• W2018649613 cites W1571140265 @default.
• W2018649613 cites W1905817477 @default.
• W2018649613 cites W194496750 @default.
• W2018649613 cites W1964841322 @default.
• W2018649613 cites W1965657682 @default.
• W2018649613 cites W1966793802 @default.
• W2018649613 cites W1967008808 @default.
• W2018649613 cites W1967015515 @default.
• W2018649613 cites W1971048984 @default.
• W2018649613 cites W1972857557 @default.
• W2018649613 cites W1973162581 @default.
• W2018649613 cites W1974133478 @default.
• W2018649613 cites W1975680543 @default.
• W2018649613 cites W1976835056 @default.
• W2018649613 cites W1978262730 @default.
• W2018649613 cites W1978702556 @default.
• W2018649613 cites W1982407988 @default.
• W2018649613 cites W1983069408 @default.
• W2018649613 cites W1984670879 @default.
• W2018649613 cites W1984963637 @default.
• W2018649613 cites W1987029855 @default.
• W2018649613 cites W1987537389 @default.
• W2018649613 cites W1989434614 @default.
• W2018649613 cites W1992865170 @default.
• W2018649613 cites W1993918745 @default.
• W2018649613 cites W1997784122 @default.
• W2018649613 cites W2003511025 @default.
• W2018649613 cites W2003726198 @default.
• W2018649613 cites W2004027717 @default.
• W2018649613 cites W2005537897 @default.
• W2018649613 cites W2005820418 @default.
• W2018649613 cites W2006670955 @default.
• W2018649613 cites W2011154525 @default.
• W2018649613 cites W2013474060 @default.
• W2018649613 cites W2014366175 @default.
• W2018649613 cites W2017101804 @default.
• W2018649613 cites W2019309426 @default.
• W2018649613 cites W2025160989 @default.
• W2018649613 cites W2026258613 @default.
• W2018649613 cites W2027624603 @default.
• W2018649613 cites W2028033845 @default.
• W2018649613 cites W2034426909 @default.
• W2018649613 cites W2034708714 @default.
• W2018649613 cites W2034888872 @default.
• W2018649613 cites W2035142210 @default.
• W2018649613 cites W2036245127 @default.
• W2018649613 cites W2036402431 @default.
• W2018649613 cites W2037618955 @default.
• W2018649613 cites W2039493738 @default.
• W2018649613 cites W2043762754 @default.
• W2018649613 cites W2044452923 @default.
• W2018649613 cites W2045971161 @default.
• W2018649613 cites W2048909283 @default.
• W2018649613 cites W2049120523 @default.
• W2018649613 cites W2051648601 @default.
• W2018649613 cites W2053179419 @default.
• W2018649613 cites W2056200715 @default.
• W2018649613 cites W2058104740 @default.
• W2018649613 cites W2059533109 @default.
• W2018649613 cites W2060628788 @default.
• W2018649613 cites W2061344417 @default.
• W2018649613 cites W2063127944 @default.
• W2018649613 cites W2063759245 @default.
• W2018649613 cites W2065585470 @default.
• W2018649613 cites W2065661642 @default.
• W2018649613 cites W2066556624 @default.
• W2018649613 cites W2067885578 @default.
• W2018649613 cites W2077043367 @default.
• W2018649613 cites W2078676430 @default.
• W2018649613 cites W2078886196 @default.
• W2018649613 cites W2081934997 @default.
• W2018649613 cites W2083684337 @default.
• W2018649613 cites W2084376094 @default.
• W2018649613 cites W2085784683 @default.
• W2018649613 cites W2086333794 @default.
• W2018649613 cites W2087886990 @default.
• W2018649613 cites W2091193926 @default.
• W2018649613 cites W2091374932 @default.
• W2018649613 cites W2092736562 @default.
• W2018649613 cites W2094514430 @default.
• W2018649613 cites W2103923698 @default.
• W2018649613 cites W2105124652 @default.
• W2018649613 cites W2107042561 @default.

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