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• W2018651544 abstract "Significance Disassembly rates and patterns of nanoparticles used as drug carriers or diagnostic tools are important determinants of their performance and biocompatibility. Thus, understanding them is essential for the design and optimization of nanoparticle formulations for clinical use. Currently available strategies are not applicable to real-time, quantitative nanoparticle disassembly analysis directly in environments of interest, such as the cell interior or biomimetic media. In the present study, a quantitative strategy using Förster resonance energy transfer for monitoring integrity status of nanoparticles in situ was developed and applied for characterizing disassembly of biodegradable polymer-based magnetic nanoparticles in vascular cells and different types of model milieu. This methodology and study results may be relevant for a broad range of biomedical and analytical applications." @default.
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• W2018651544 date "2014-03-03" @default.
• W2018651544 modified "2023-10-14" @default.
• W2018651544 title "Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media" @default.
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• W2018651544 doi "https://doi.org/10.1073/pnas.1324104111" @default.
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