FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018655134> ?p ?o ?g. }

• W2018655134 endingPage "3306" @default.
• W2018655134 startingPage "3300" @default.
• W2018655134 abstract "Previous studies have suggested an important role of the cytokine adjuvant IL-6 in the induction of mucosal immune responses in animals, including mice. Here, we report the in vivo ability of bovine adenovirus (BAdV)-3 expressing bovine (Bo) IL-6, to influence the systemic and mucosal immune responses against bovine herpesvirus (BHV)-1 gDt in calves. To co-express both antigen and cytokine, we first constructed a recombinant BAdV-3 expressing chimeric gDt.BoIL-6 protein (BAV326). Secondly, we constructed another recombinant BAdV-3 simultaneously expressing gDt and BoIL-6 using IRES containing a bicistronic cassette gDt-IRES.IL-6, (BAV327). Recombinant proteins expressed by BAV326 and BAV327 retained antigenicity (gDt) and biological activity (BoIL-6). Intranasal immunization of calves with recombinant BAV326, BAV327 or BAV308 (gDt alone) resulted in demonstrable levels of gDt-specific IgG responses in sera and IgA response in nasal secretions, in all animals. In addition, all calves developed complement-independent neutralizing antibody responses against BHV-1. However, no significant difference could be observed in the induction of systemic or mucosal immune response in animals immunized with recombinant BAV326 or BAV327 co-expressing BoIL-6. Moreover, there was no difference in the protection against BHV-1 challenge particularly in the amount of virus excretion in the nasal cavity in calves immunized with BAV326, BAV327 or BAV308. These data suggest that the BoIL-6 had no modulating effect on the induction of gDt specific mucosal and systemic immune responses in calves." @default.
• W2018655134 created "2016-06-24" @default.
• W2018655134 creator A5019279273 @default.
• W2018655134 creator A5028351806 @default.
• W2018655134 creator A5049654457 @default.
• W2018655134 creator A5057902245 @default.
• W2018655134 creator A5079330921 @default.
• W2018655134 creator A5085793553 @default.
• W2018655134 date "2014-05-01" @default.
• W2018655134 modified "2023-10-18" @default.
• W2018655134 title "Mucosal immunization of calves with recombinant bovine adenovirus-3 coexpressing truncated form of bovine herpesvirus-1 gD and bovine IL-6" @default.
• W2018655134 cites W1526324407 @default.
• W2018655134 cites W1541174496 @default.
• W2018655134 cites W1582536607 @default.
• W2018655134 cites W1853022482 @default.
• W2018655134 cites W1899708280 @default.
• W2018655134 cites W1917885463 @default.
• W2018655134 cites W1964006302 @default.
• W2018655134 cites W1970623056 @default.
• W2018655134 cites W1984915036 @default.
• W2018655134 cites W1992344690 @default.
• W2018655134 cites W1993630121 @default.
• W2018655134 cites W1995315280 @default.
• W2018655134 cites W2000471385 @default.
• W2018655134 cites W2000853857 @default.
• W2018655134 cites W2014261133 @default.
• W2018655134 cites W2017873272 @default.
• W2018655134 cites W2025568005 @default.
• W2018655134 cites W2030087392 @default.
• W2018655134 cites W2045086064 @default.
• W2018655134 cites W2045508783 @default.
• W2018655134 cites W2047154075 @default.
• W2018655134 cites W2049771938 @default.
• W2018655134 cites W2054945280 @default.
• W2018655134 cites W2067976882 @default.
• W2018655134 cites W2076506003 @default.
• W2018655134 cites W2082150927 @default.
• W2018655134 cites W2083033324 @default.
• W2018655134 cites W2088251586 @default.
• W2018655134 cites W2089690542 @default.
• W2018655134 cites W2090147724 @default.
• W2018655134 cites W2091064926 @default.
• W2018655134 cites W2103092501 @default.
• W2018655134 cites W2106389211 @default.
• W2018655134 cites W2107651416 @default.
• W2018655134 cites W2110840013 @default.
• W2018655134 cites W2111492240 @default.
• W2018655134 cites W2114315319 @default.
• W2018655134 cites W2122576851 @default.
• W2018655134 cites W2126022534 @default.
• W2018655134 cites W2135392289 @default.
• W2018655134 cites W2144315197 @default.
• W2018655134 cites W2149339351 @default.
• W2018655134 cites W2154075915 @default.
• W2018655134 cites W2155642886 @default.
• W2018655134 cites W2159076362 @default.
• W2018655134 cites W2291946607 @default.
• W2018655134 cites W2332756899 @default.
• W2018655134 cites W4313308328 @default.
• W2018655134 doi "https://doi.org/10.1016/j.vaccine.2014.03.073" @default.
• W2018655134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24731813" @default.
• W2018655134 hasPublicationYear "2014" @default.
• W2018655134 type Work @default.
• W2018655134 sameAs 2018655134 @default.
• W2018655134 citedByCount "13" @default.
• W2018655134 countsByYear W20186551342014 @default.
• W2018655134 countsByYear W20186551342015 @default.
• W2018655134 countsByYear W20186551342016 @default.
• W2018655134 countsByYear W20186551342017 @default.
• W2018655134 countsByYear W20186551342018 @default.
• W2018655134 countsByYear W20186551342020 @default.
• W2018655134 crossrefType "journal-article" @default.
• W2018655134 hasAuthorship W2018655134A5019279273 @default.
• W2018655134 hasAuthorship W2018655134A5028351806 @default.
• W2018655134 hasAuthorship W2018655134A5049654457 @default.
• W2018655134 hasAuthorship W2018655134A5057902245 @default.
• W2018655134 hasAuthorship W2018655134A5079330921 @default.
• W2018655134 hasAuthorship W2018655134A5085793553 @default.
• W2018655134 hasConcept C104317684 @default.
• W2018655134 hasConcept C147483822 @default.
• W2018655134 hasConcept C159047783 @default.
• W2018655134 hasConcept C159654299 @default.
• W2018655134 hasConcept C203014093 @default.
• W2018655134 hasConcept C2522874641 @default.
• W2018655134 hasConcept C2776409557 @default.
• W2018655134 hasConcept C2777594917 @default.
• W2018655134 hasConcept C2777863537 @default.
• W2018655134 hasConcept C2779261636 @default.
• W2018655134 hasConcept C2780727368 @default.
• W2018655134 hasConcept C2780801004 @default.
• W2018655134 hasConcept C40767141 @default.
• W2018655134 hasConcept C55493867 @default.
• W2018655134 hasConcept C86803240 @default.
• W2018655134 hasConcept C8891405 @default.
• W2018655134 hasConceptScore W2018655134C104317684 @default.
• W2018655134 hasConceptScore W2018655134C147483822 @default.
• W2018655134 hasConceptScore W2018655134C159047783 @default.
• W2018655134 hasConceptScore W2018655134C159654299 @default.

• next