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• W2018660612 abstract "Lycopene, obtained from fresh tomatoes, was incorporated into the chicks diet. The treatments were: (1) Control, (2) 1.5 mg T-2 toxin/kg body weight/day; (3) 25 mg lycopene/kg body weight/day, (4) 1.5 mg T-2 toxin plus 25 mg lycopene/kg body weight/day. Male broiler chicks, 7–28 days of age, were provided with feed and water ad libitum. Every 7 days, malondialdehyde (MDA) and glutathione (GSH) levels, and enzymatic activities of glutathione-S-transferase (GST), γ-glutamyltransferase (GGT) and glutathione peroxidase (GP) were evaluated in liver homogenates. Compared to the controls after 7 days of treatment, T-2 toxin increased hepatic MDA concentration (128%). A significant consumption of endogenous antioxidant GSH (45%) was induced as well as a marked increase in hepatic enzymatic activities of GST, GGT, and GP (312, 187, and 324%, respectively). Addition of T-2 plus lycopene, at an approximate ratio of 1:17 in the diet, diminished some parameters measured (P<0.05). Apparently lycopene participated as an antioxidant agent and also protecting the cellular level of GSH." @default.
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• W2018660612 date "1999-09-01" @default.
• W2018660612 modified "2023-09-30" @default.
• W2018660612 title "Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo" @default.
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• W2018660612 doi "https://doi.org/10.1016/s0378-4274(99)00062-4" @default.
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