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• W2018660714 abstract "The haemoglobinopathies commonly encountered in the context of childbirth are described, both in terms of their molecular pathology and their clinical features. The important distinctions between the haemoglobin variants and the thalassaemias, and between homozygotes and heterozygotes are explained. The inheritance of these disorders is discussed, and the principles of genetic counselling and antenatal diagnosis which can be applied to them. Some of the haemoglobinopathies have features which have major effects during fetal life or in infancy, and thus adults of child-bearing age are not encountered with these conditions. Sickle cell disease, however, which does not manifest itself clinically until an infant is about 6-months-old, is seen in a small but significant number of antenatal patients (probably some 30 per year in the UK), and is associated with serious complication rates both for the mother and the fetus. The appropriate management of women with haemoglobinopathies during pregnancy is outlined, and the choice of methods of contraception for these women is discussed." @default.
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• W2018660714 date "1985-09-01" @default.
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• W2018660714 title "Haemoglobinopathies and their effect on childbirth" @default.
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• W2018660714 doi "https://doi.org/10.1016/s0266-6138(85)80035-8" @default.
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