FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018662989> ?p ?o ?g. }

• W2018662989 endingPage "435" @default.
• W2018662989 startingPage "424" @default.
• W2018662989 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) and the proopiomelanocortin (POMC)-derived peptide, α-melanocyte-stimulating hormone (α-MSH), exert anorexigenic activities. While α-MSH is known to inhibit food intake and stimulate catabolism via activation of the central melanocortin-receptor MC4-R, little is known regarding the mechanism by which PACAP inhibits food consumption. We have recently found that, in the arcuate nucleus of the hypothalamus, a high proportion of POMC neurons express PACAP receptors. This observation led us to investigate whether PACAP may inhibit food intake through a POMC-dependent mechanism. In mice deprived of food for 18 h, intracerebroventricular administration of PACAP significantly reduced food intake after 30 min, and this effect was reversed by the PACAP antagonist PACAP6-38. In contrast, vasoactive intestinal polypeptide did not affect feeding behavior. Pretreatment with the MC3-R/MC4-R antagonist SHU9119 significantly reduced the effect of PACAP on food consumption. Central administration of PACAP induced c-Fos mRNA expression and increased the proportion of POMC neuron-expressing c-Fos mRNA in the arcuate nucleus. Furthermore, PACAP provoked an increase in POMC and MC4-R mRNA expression in the hypothalamus, while MC3-R mRNA level was not affected. POMC mRNA level in the arcuate nucleus of PACAP-specific receptor (PAC1-R) knock-out mice was reduced as compared with wild-type animals. Finally, i.c.v. injection of PACAP provoked a significant increase in plasma glucose level. Altogether, these results indicate that PACAP, acting through PAC1-R, may inhibit food intake via a melanocortin-dependent pathway. These data also suggest a central action of PACAP in the control of glucose metabolism." @default.
• W2018662989 created "2016-06-24" @default.
• W2018662989 creator A5003795666 @default.
• W2018662989 creator A5004167802 @default.
• W2018662989 creator A5015125277 @default.
• W2018662989 creator A5027135372 @default.
• W2018662989 creator A5029615414 @default.
• W2018662989 creator A5031224564 @default.
• W2018662989 creator A5056192460 @default.
• W2018662989 creator A5071247559 @default.
• W2018662989 creator A5077903137 @default.
• W2018662989 creator A5085413597 @default.
• W2018662989 date "2008-06-04" @default.
• W2018662989 modified "2023-10-18" @default.
• W2018662989 title "Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System" @default.
• W2018662989 cites W11739137 @default.
• W2018662989 cites W1488596761 @default.
• W2018662989 cites W1539401343 @default.
• W2018662989 cites W1577371918 @default.
• W2018662989 cites W1607718154 @default.
• W2018662989 cites W1968309695 @default.
• W2018662989 cites W1968537133 @default.
• W2018662989 cites W1968916313 @default.
• W2018662989 cites W1969304868 @default.
• W2018662989 cites W1971371480 @default.
• W2018662989 cites W1972939738 @default.
• W2018662989 cites W1974983579 @default.
• W2018662989 cites W1979067492 @default.
• W2018662989 cites W1981423842 @default.
• W2018662989 cites W1989044425 @default.
• W2018662989 cites W1993137505 @default.
• W2018662989 cites W1996764763 @default.
• W2018662989 cites W1999332228 @default.
• W2018662989 cites W2002606463 @default.
• W2018662989 cites W2005658382 @default.
• W2018662989 cites W2008872075 @default.
• W2018662989 cites W2010142606 @default.
• W2018662989 cites W2013273018 @default.
• W2018662989 cites W2014585127 @default.
• W2018662989 cites W2016261339 @default.
• W2018662989 cites W2024697593 @default.
• W2018662989 cites W2025860749 @default.
• W2018662989 cites W2027740042 @default.
• W2018662989 cites W2030144601 @default.
• W2018662989 cites W2033650768 @default.
• W2018662989 cites W2034355463 @default.
• W2018662989 cites W2034760759 @default.
• W2018662989 cites W2036031897 @default.
• W2018662989 cites W2036471756 @default.
• W2018662989 cites W2042669795 @default.
• W2018662989 cites W2044571348 @default.
• W2018662989 cites W2048266255 @default.
• W2018662989 cites W2051841999 @default.
• W2018662989 cites W2058586676 @default.
• W2018662989 cites W2062084912 @default.
• W2018662989 cites W2065389660 @default.
• W2018662989 cites W2074828120 @default.
• W2018662989 cites W2088637181 @default.
• W2018662989 cites W2098181391 @default.
• W2018662989 cites W2104751353 @default.
• W2018662989 cites W2126757984 @default.
• W2018662989 cites W2136803357 @default.
• W2018662989 cites W2139571357 @default.
• W2018662989 cites W2160088320 @default.
• W2018662989 cites W2169222199 @default.
• W2018662989 cites W4236558664 @default.
• W2018662989 cites W4251405489 @default.
• W2018662989 cites W4294216491 @default.
• W2018662989 cites W4361743021 @default.
• W2018662989 doi "https://doi.org/10.1038/npp.2008.73" @default.
• W2018662989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18536705" @default.
• W2018662989 hasPublicationYear "2008" @default.
• W2018662989 type Work @default.
• W2018662989 sameAs 2018662989 @default.
• W2018662989 citedByCount "89" @default.
• W2018662989 countsByYear W20186629892012 @default.
• W2018662989 countsByYear W20186629892013 @default.
• W2018662989 countsByYear W20186629892014 @default.
• W2018662989 countsByYear W20186629892015 @default.
• W2018662989 countsByYear W20186629892016 @default.
• W2018662989 countsByYear W20186629892017 @default.
• W2018662989 countsByYear W20186629892018 @default.
• W2018662989 countsByYear W20186629892019 @default.
• W2018662989 countsByYear W20186629892020 @default.
• W2018662989 countsByYear W20186629892021 @default.
• W2018662989 countsByYear W20186629892022 @default.
• W2018662989 countsByYear W20186629892023 @default.
• W2018662989 crossrefType "journal-article" @default.
• W2018662989 hasAuthorship W2018662989A5003795666 @default.
• W2018662989 hasAuthorship W2018662989A5004167802 @default.
• W2018662989 hasAuthorship W2018662989A5015125277 @default.
• W2018662989 hasAuthorship W2018662989A5027135372 @default.
• W2018662989 hasAuthorship W2018662989A5029615414 @default.
• W2018662989 hasAuthorship W2018662989A5031224564 @default.
• W2018662989 hasAuthorship W2018662989A5056192460 @default.
• W2018662989 hasAuthorship W2018662989A5071247559 @default.
• W2018662989 hasAuthorship W2018662989A5077903137 @default.
• W2018662989 hasAuthorship W2018662989A5085413597 @default.

• next