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- W2018668845 startingPage "3681" @default.
- W2018668845 abstract "There is a plethora of attractive drug targets in cancer, but their therapeutic exploitation proved more difficult than expected, and only rarely truly successful. One possibility not often considered in drug discovery is that cancer signaling pathways are not randomly arranged in cells, but orchestrated in specialized subcellular compartments. The identification of heat shock protein-90 (Hsp90) chaperones in mitochondria of tumors, but not most normal tissues, provides an example of a compartmentalized network of cell survival, opening fresh prospects for novel, subcellularly targeted cancer drug discovery." @default.
- W2018668845 created "2016-06-24" @default.
- W2018668845 creator A5021577151 @default.
- W2018668845 creator A5082346201 @default.
- W2018668845 date "2009-08-03" @default.
- W2018668845 modified "2023-09-30" @default.
- W2018668845 title "Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones" @default.
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- W2018668845 doi "https://doi.org/10.1038/onc.2009.227" @default.
- W2018668845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2766018" @default.
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