Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018673669> ?p ?o ?g. }
- W2018673669 endingPage "e1002248" @default.
- W2018673669 startingPage "e1002248" @default.
- W2018673669 abstract "Replication of non-segmented negative-strand RNA viruses requires the continuous supply of the nucleoprotein (N) in the form of a complex with the phosphoprotein (P). Here, we present the structural characterization of a soluble, heterodimeric complex between a variant of vesicular stomatitis virus N lacking its 21 N-terminal residues (NΔ21) and a peptide of 60 amino acids (P60) encompassing the molecular recognition element (MoRE) of P that binds RNA-free N (N0). The complex crystallized in a decameric circular form, which was solved at 3.0 Å resolution, reveals how the MoRE folds upon binding to N and competes with RNA binding and N polymerization. Small-angle X-ray scattering experiment and NMR spectroscopy on the soluble complex confirms the binding of the MoRE and indicates that its flanking regions remain flexible in the complex. The structure of this complex also suggests a mechanism for the initiation of viral RNA synthesis." @default.
- W2018673669 created "2016-06-24" @default.
- W2018673669 creator A5001250430 @default.
- W2018673669 creator A5018221555 @default.
- W2018673669 creator A5028711445 @default.
- W2018673669 creator A5032811653 @default.
- W2018673669 creator A5047719348 @default.
- W2018673669 creator A5051779729 @default.
- W2018673669 creator A5089286435 @default.
- W2018673669 creator A5091634068 @default.
- W2018673669 date "2011-09-22" @default.
- W2018673669 modified "2023-10-04" @default.
- W2018673669 title "Structure of the Vesicular Stomatitis Virus N0-P Complex" @default.
- W2018673669 cites W1483117497 @default.
- W2018673669 cites W1504671519 @default.
- W2018673669 cites W1825536795 @default.
- W2018673669 cites W1862285788 @default.
- W2018673669 cites W1969542352 @default.
- W2018673669 cites W1972610556 @default.
- W2018673669 cites W1973063795 @default.
- W2018673669 cites W1973962907 @default.
- W2018673669 cites W1975601397 @default.
- W2018673669 cites W1982126789 @default.
- W2018673669 cites W1986191025 @default.
- W2018673669 cites W1986329853 @default.
- W2018673669 cites W1990775747 @default.
- W2018673669 cites W1991969703 @default.
- W2018673669 cites W1992191979 @default.
- W2018673669 cites W1994342014 @default.
- W2018673669 cites W1994553113 @default.
- W2018673669 cites W2008268465 @default.
- W2018673669 cites W2013445305 @default.
- W2018673669 cites W2021527318 @default.
- W2018673669 cites W2022987595 @default.
- W2018673669 cites W2031803237 @default.
- W2018673669 cites W2038840577 @default.
- W2018673669 cites W2041880200 @default.
- W2018673669 cites W2050091361 @default.
- W2018673669 cites W2057019124 @default.
- W2018673669 cites W2081380911 @default.
- W2018673669 cites W2086395824 @default.
- W2018673669 cites W2093486445 @default.
- W2018673669 cites W2102296603 @default.
- W2018673669 cites W2103223052 @default.
- W2018673669 cites W2119022697 @default.
- W2018673669 cites W2124026197 @default.
- W2018673669 cites W2124983865 @default.
- W2018673669 cites W2129879061 @default.
- W2018673669 cites W2140181549 @default.
- W2018673669 cites W2143815085 @default.
- W2018673669 cites W2145136550 @default.
- W2018673669 cites W2149885731 @default.
- W2018673669 cites W2152448366 @default.
- W2018673669 cites W2161795155 @default.
- W2018673669 cites W2163341755 @default.
- W2018673669 cites W2164209237 @default.
- W2018673669 doi "https://doi.org/10.1371/journal.ppat.1002248" @default.
- W2018673669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3178552" @default.
- W2018673669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21960769" @default.
- W2018673669 hasPublicationYear "2011" @default.
- W2018673669 type Work @default.
- W2018673669 sameAs 2018673669 @default.
- W2018673669 citedByCount "112" @default.
- W2018673669 countsByYear W20186736692012 @default.
- W2018673669 countsByYear W20186736692013 @default.
- W2018673669 countsByYear W20186736692014 @default.
- W2018673669 countsByYear W20186736692015 @default.
- W2018673669 countsByYear W20186736692016 @default.
- W2018673669 countsByYear W20186736692017 @default.
- W2018673669 countsByYear W20186736692018 @default.
- W2018673669 countsByYear W20186736692019 @default.
- W2018673669 countsByYear W20186736692020 @default.
- W2018673669 countsByYear W20186736692021 @default.
- W2018673669 countsByYear W20186736692022 @default.
- W2018673669 countsByYear W20186736692023 @default.
- W2018673669 crossrefType "journal-article" @default.
- W2018673669 hasAuthorship W2018673669A5001250430 @default.
- W2018673669 hasAuthorship W2018673669A5018221555 @default.
- W2018673669 hasAuthorship W2018673669A5028711445 @default.
- W2018673669 hasAuthorship W2018673669A5032811653 @default.
- W2018673669 hasAuthorship W2018673669A5047719348 @default.
- W2018673669 hasAuthorship W2018673669A5051779729 @default.
- W2018673669 hasAuthorship W2018673669A5089286435 @default.
- W2018673669 hasAuthorship W2018673669A5091634068 @default.
- W2018673669 hasBestOaLocation W20186736691 @default.
- W2018673669 hasConcept C104317684 @default.
- W2018673669 hasConcept C107824862 @default.
- W2018673669 hasConcept C12554922 @default.
- W2018673669 hasConcept C159047783 @default.
- W2018673669 hasConcept C185592680 @default.
- W2018673669 hasConcept C2522874641 @default.
- W2018673669 hasConcept C2777061661 @default.
- W2018673669 hasConcept C2779057330 @default.
- W2018673669 hasConcept C55493867 @default.
- W2018673669 hasConcept C60325843 @default.
- W2018673669 hasConcept C67705224 @default.
- W2018673669 hasConcept C86803240 @default.
- W2018673669 hasConceptScore W2018673669C104317684 @default.