FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018676819> ?p ?o ?g. }

• W2018676819 endingPage "1761" @default.
• W2018676819 startingPage "1756" @default.
• W2018676819 abstract "Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hospital (Boston, MA) from 1983 to 1995 to assess whether cell-mediated cytotoxicity, determined in vitro and measured before transplantation, was predictive of chronic rejection.Eighty-three patients were studied retrospectively. Fifty-seven patients with one haplotype-matched renal transplants from living related donors were studied to determine the association between cell-mediated lympholysis (CML) level, acute rejection, chronic rejection, and graft failure. Acute rejection was defined by the decision to treat. Chronic rejection was defined by histology and/or the absolute serum creatinine value using an increasing serum creatinine level >1.0 mg/dl for children less than 3, a creatinine level >1.5 mg/dl for children between 3 and 10 years of age, and a creatinine level >2.0 mg/dl for children above 10 years of age. Return to dialysis or retransplantation was considered graft failure.Of the 57 haploidentical patients, there were 33 males and 24 females. The mean age at transplant was 11.1 years (SD=6.7). Twelve patients developed chronic rejection, 24 patients developed acute rejection, and 7 patients had graft failure. Pretransplant cytotoxic T lymphocyte activity was associated with chronic rejection (P=0.001) and graft failure (P=0.013) but only marginally with acute rejection (P=0.058). Controlling for age and sex, Cox's proportional hazards model revealed that CML level was predictive of time to chronic rejection (P<0.01) but not acute rejection (P=0.11). It was estimated that every 1-unit increase in CML level raises the monthly risk of chronic rejection by 7%. Ten children received HLA-identical kidneys from their siblings. There were no episodes of chronic rejection after 5 years. Two patients with high CML levels had episodes of acute rejection; both patients responded to treatment.Our data demonstrate an association between pretransplant cell-mediated cytotoxicity and the occurrence of chronic rejection in living related one-haploidentical renal transplants in pediatric patients." @default.
• W2018676819 created "2016-06-24" @default.
• W2018676819 creator A5008733728 @default.
• W2018676819 creator A5011532156 @default.
• W2018676819 creator A5017712810 @default.
• W2018676819 creator A5029802394 @default.
• W2018676819 creator A5039072840 @default.
• W2018676819 creator A5055741201 @default.
• W2018676819 creator A5078957704 @default.
• W2018676819 creator A5081707167 @default.
• W2018676819 creator A5091442072 @default.
• W2018676819 date "1997-06-01" @default.
• W2018676819 modified "2023-09-23" @default.
• W2018676819 title "CELL-MEDIATED CYTOTOXICITY: A PREDICTOR OF CHRONIC REJECTION IN PEDIATRIC HLA HAPLOIDENTICAL RENAL TRANSPLANTS1" @default.
• W2018676819 cites W1969971113 @default.
• W2018676819 cites W1970744236 @default.
• W2018676819 cites W1973647958 @default.
• W2018676819 cites W1997211407 @default.
• W2018676819 cites W2023893380 @default.
• W2018676819 cites W2036039626 @default.
• W2018676819 cites W2040712999 @default.
• W2018676819 cites W2044812679 @default.
• W2018676819 cites W2052977840 @default.
• W2018676819 cites W2060145044 @default.
• W2018676819 cites W2065505727 @default.
• W2018676819 cites W2073564921 @default.
• W2018676819 cites W2093603781 @default.
• W2018676819 cites W2119202441 @default.
• W2018676819 cites W2316601436 @default.
• W2018676819 cites W2324342306 @default.
• W2018676819 cites W4245480267 @default.
• W2018676819 cites W4245875333 @default.
• W2018676819 cites W4293241248 @default.
• W2018676819 doi "https://doi.org/10.1097/00007890-199706270-00009" @default.
• W2018676819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9210500" @default.
• W2018676819 hasPublicationYear "1997" @default.
• W2018676819 type Work @default.
• W2018676819 sameAs 2018676819 @default.
• W2018676819 citedByCount "6" @default.
• W2018676819 crossrefType "journal-article" @default.
• W2018676819 hasAuthorship W2018676819A5008733728 @default.
• W2018676819 hasAuthorship W2018676819A5011532156 @default.
• W2018676819 hasAuthorship W2018676819A5017712810 @default.
• W2018676819 hasAuthorship W2018676819A5029802394 @default.
• W2018676819 hasAuthorship W2018676819A5039072840 @default.
• W2018676819 hasAuthorship W2018676819A5055741201 @default.
• W2018676819 hasAuthorship W2018676819A5078957704 @default.
• W2018676819 hasAuthorship W2018676819A5081707167 @default.
• W2018676819 hasAuthorship W2018676819A5091442072 @default.
• W2018676819 hasBestOaLocation W20186768191 @default.
• W2018676819 hasConcept C126322002 @default.
• W2018676819 hasConcept C126894567 @default.
• W2018676819 hasConcept C141071460 @default.
• W2018676819 hasConcept C147483822 @default.
• W2018676819 hasConcept C154317977 @default.
• W2018676819 hasConcept C159641895 @default.
• W2018676819 hasConcept C185592680 @default.
• W2018676819 hasConcept C188280979 @default.
• W2018676819 hasConcept C202751555 @default.
• W2018676819 hasConcept C203014093 @default.
• W2018676819 hasConcept C2779978075 @default.
• W2018676819 hasConcept C2780306776 @default.
• W2018676819 hasConcept C2911091166 @default.
• W2018676819 hasConcept C55493867 @default.
• W2018676819 hasConcept C71924100 @default.
• W2018676819 hasConcept C90924648 @default.
• W2018676819 hasConceptScore W2018676819C126322002 @default.
• W2018676819 hasConceptScore W2018676819C126894567 @default.
• W2018676819 hasConceptScore W2018676819C141071460 @default.
• W2018676819 hasConceptScore W2018676819C147483822 @default.
• W2018676819 hasConceptScore W2018676819C154317977 @default.
• W2018676819 hasConceptScore W2018676819C159641895 @default.
• W2018676819 hasConceptScore W2018676819C185592680 @default.
• W2018676819 hasConceptScore W2018676819C188280979 @default.
• W2018676819 hasConceptScore W2018676819C202751555 @default.
• W2018676819 hasConceptScore W2018676819C203014093 @default.
• W2018676819 hasConceptScore W2018676819C2779978075 @default.
• W2018676819 hasConceptScore W2018676819C2780306776 @default.
• W2018676819 hasConceptScore W2018676819C2911091166 @default.
• W2018676819 hasConceptScore W2018676819C55493867 @default.
• W2018676819 hasConceptScore W2018676819C71924100 @default.
• W2018676819 hasConceptScore W2018676819C90924648 @default.
• W2018676819 hasIssue "12" @default.
• W2018676819 hasLocation W20186768191 @default.
• W2018676819 hasLocation W20186768192 @default.
• W2018676819 hasLocation W20186768193 @default.
• W2018676819 hasOpenAccess W2018676819 @default.
• W2018676819 hasPrimaryLocation W20186768191 @default.
• W2018676819 hasRelatedWork W1486584413 @default.
• W2018676819 hasRelatedWork W1544023406 @default.
• W2018676819 hasRelatedWork W1973741567 @default.
• W2018676819 hasRelatedWork W1974378936 @default.
• W2018676819 hasRelatedWork W2046899919 @default.
• W2018676819 hasRelatedWork W2087086071 @default.
• W2018676819 hasRelatedWork W2509590939 @default.
• W2018676819 hasRelatedWork W3117263584 @default.
• W2018676819 hasRelatedWork W393698729 @default.
• W2018676819 hasRelatedWork W4296385806 @default.

• next