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• W2018678702 endingPage "265" @default.
• W2018678702 startingPage "252" @default.
• W2018678702 abstract "The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. GTP is hydrolytically opened, converted into 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction and dephosphorylation. Condensation with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate leads to 6,7-dimethyl-8-ribityllumazine. The final step in the biosynthesis of the vitamin involves the dismutation of 6,7-dimethyl-8-ribityllumazine catalyzed by riboflavin synthase. The mechanistically unusual reaction involves the transfer of a four-carbon fragment between two identical substrate molecules. The second product, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, is recycled in the biosynthetic pathway by 6,7-dimethyl-8-ribityllumazine synthase. This article will review structures and reaction mechanisms of riboflavin synthases and related proteins up to 2007 and 122 references are cited." @default.
• W2018678702 created "2016-06-24" @default.
• W2018678702 creator A5006304159 @default.
• W2018678702 creator A5068798153 @default.
• W2018678702 date "2008-06-01" @default.
• W2018678702 modified "2023-10-06" @default.
• W2018678702 title "Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase" @default.
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