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• W2018681063 abstract "Cardiac remodelling is a progressive process after myocardial infarction (MI). However, currently there are no data regarding the effect of elapsed time from MI on the benefit of cardiac resynchronization therapy with defibrillator (CRT-D). The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM). The risk of heart failure (HF) or death as a function of elapsed time from MI to enrolment, by treatment with CRT-D vs. implantable cardioverter defibrillator (ICD)-only therapy, was assessed among 704 ICM patients with a documented MI enrolled in MADIT-CRT, and separately in a subset of ICM patients without a documented prior MI (n = 237). In ICD patients, the adjusted risk of HF or death increased by 4% (P = 0.01) for each year elapsed from MI. Multivariate analysis demonstrated that patients with remote MI [categorized at the median value (≥8 years)] derived a significantly greater benefit from CRT-D [HR = 0.42 (P < 0.001)] than those with a more recent MI [HR = 1.26 (P = 0.35); P-value for interaction <0.001]. Consistently, the benefit of CRT-D was directly related to increasing quartiles of elapsed time from MI [Q1 (<3 years): HR = 1.67; P = 0.20, Q2 (3–8 years): HR = 1.12; P = 0.71, Q3 (8–15 years): HR = 0.47; P = 0.02, and Q4 (≥15 years): HR = 0.38; P = 0.001]. The ICM subgroup with no documented MI also derived enhanced benefit from CRT-D (HR = 0.43; P = 0.003). In patients with ischaemic cardiomyopathy, the risk of HF or death and the magnitude of CRT-D benefit are directly related to elapsed time from MI." @default.
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• W2018681063 date "2010-11-12" @default.
• W2018681063 modified "2023-09-26" @default.
• W2018681063 title "Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarction" @default.
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• W2018681063 doi "https://doi.org/10.1093/eurheartj/ehq392" @default.
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