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- W2018682712 abstract "In order to develop slowly dissolving particles containing the antileprotic drug dapsone (4,4'-sulfonylbisbenzamine, that would be suitable for a sustained-release intramuscular injection, the dilauryl and monolauryl derivatives of dapsone, N,N'-didodecanoyl-4,4'-sulfonylbisbenzamine and N-dodecanoyl-4,4'-sulfonylbisbenzamine, respectively, were studied for their ability to form solid dispersions with the parent compound. The 1:2 binary phase diagram showed these two compounds were partially miscible in the liquid state, leading to the coexistence of a monotectic and a eutectic system in the phase diagram. The 1:3 phase diagram showed that these compounds were completely miscible in the liquid state and formed discontinuous solid solutions in the solid state. At a cooling rate of 2.5 degrees C min-1, eutectic mixtures lying on the dapsone side of the eutectic point formed glass solutions. Taken as a whole, the results demonstrate that the molecular interactions between 1 and 3 are stronger than those between 1 and 2. Accordingly, 3 would appear to be the better carrier for reducing the rate of dissolution of dapsone from a solid dispersion." @default.
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- W2018682712 date "1986-01-01" @default.
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- W2018682712 title "Sustained-Release Delivery Systems, I: Phase Diagram Studies of Dapsone and Selected Derivatives" @default.
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- W2018682712 doi "https://doi.org/10.1002/jps.2600750112" @default.
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