Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018683003> ?p ?o ?g. }
- W2018683003 endingPage "1029" @default.
- W2018683003 startingPage "1013" @default.
- W2018683003 abstract "Genetic analysis has revealed an important function in myogenesis for Myostatin, a member of the TGF-beta superfamily. However, the cascade of genes that responds to Myostatin signalling to regulate myogenesis is not well understood. Thus, a suppressive subtraction hybridization to identify such genes was undertaken and here we report the cloning and characterization of a novel gene, Mighty. Mighty is expressed in a variety of different tissues but appears to be specifically regulated by Myostatin in skeletal muscle. Overexpression of Mighty in C2C12 cells results in early withdrawal of myoblasts from the cell cycle, enhanced and accelerated differentiation and hypertrophy of myotubes. Most importantly, Mighty overexpression leads to increased and earlier expression of MyoD and increased secretion of another known differentiation inducing factor, IGF-II. Furthermore, viral expression of Mighty in mdx mice resulted in an increase in the number of larger healthy muscle fibers. Given its role in myogenesis, we propose that Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin." @default.
- W2018683003 created "2016-06-24" @default.
- W2018683003 creator A5004736114 @default.
- W2018683003 creator A5011018903 @default.
- W2018683003 creator A5024586091 @default.
- W2018683003 creator A5053827994 @default.
- W2018683003 creator A5056823565 @default.
- W2018683003 creator A5058024376 @default.
- W2018683003 creator A5065948214 @default.
- W2018683003 creator A5066707974 @default.
- W2018683003 creator A5075076266 @default.
- W2018683003 creator A5077881176 @default.
- W2018683003 creator A5081375937 @default.
- W2018683003 creator A5091615720 @default.
- W2018683003 date "2008-03-01" @default.
- W2018683003 modified "2023-10-16" @default.
- W2018683003 title "Mighty is a novel promyogenic factor in skeletal myogenesis" @default.
- W2018683003 cites W1964733862 @default.
- W2018683003 cites W1973546377 @default.
- W2018683003 cites W1979046428 @default.
- W2018683003 cites W1982864167 @default.
- W2018683003 cites W1992001551 @default.
- W2018683003 cites W2025301493 @default.
- W2018683003 cites W2025463260 @default.
- W2018683003 cites W2038318576 @default.
- W2018683003 cites W2042663178 @default.
- W2018683003 cites W2052651806 @default.
- W2018683003 cites W2053079324 @default.
- W2018683003 cites W2054027756 @default.
- W2018683003 cites W2055789788 @default.
- W2018683003 cites W2060874227 @default.
- W2018683003 cites W2061937899 @default.
- W2018683003 cites W2063631572 @default.
- W2018683003 cites W2067486237 @default.
- W2018683003 cites W2070667194 @default.
- W2018683003 cites W2071203800 @default.
- W2018683003 cites W2079643152 @default.
- W2018683003 cites W2082476308 @default.
- W2018683003 cites W2082867992 @default.
- W2018683003 cites W2092731915 @default.
- W2018683003 cites W2106562809 @default.
- W2018683003 cites W2110074960 @default.
- W2018683003 cites W2116961946 @default.
- W2018683003 cites W2122059149 @default.
- W2018683003 cites W2123477786 @default.
- W2018683003 cites W2130122556 @default.
- W2018683003 cites W2137814808 @default.
- W2018683003 cites W2138808656 @default.
- W2018683003 cites W2140771257 @default.
- W2018683003 cites W2141725752 @default.
- W2018683003 cites W2152128819 @default.
- W2018683003 cites W2152264745 @default.
- W2018683003 cites W2153289066 @default.
- W2018683003 cites W2160199212 @default.
- W2018683003 cites W2164552342 @default.
- W2018683003 cites W2164615751 @default.
- W2018683003 cites W2165868509 @default.
- W2018683003 cites W2420065591 @default.
- W2018683003 doi "https://doi.org/10.1016/j.yexcr.2008.01.004" @default.
- W2018683003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18255059" @default.
- W2018683003 hasPublicationYear "2008" @default.
- W2018683003 type Work @default.
- W2018683003 sameAs 2018683003 @default.
- W2018683003 citedByCount "75" @default.
- W2018683003 countsByYear W20186830032012 @default.
- W2018683003 countsByYear W20186830032013 @default.
- W2018683003 countsByYear W20186830032014 @default.
- W2018683003 countsByYear W20186830032015 @default.
- W2018683003 countsByYear W20186830032016 @default.
- W2018683003 countsByYear W20186830032017 @default.
- W2018683003 countsByYear W20186830032018 @default.
- W2018683003 countsByYear W20186830032019 @default.
- W2018683003 countsByYear W20186830032020 @default.
- W2018683003 countsByYear W20186830032021 @default.
- W2018683003 countsByYear W20186830032022 @default.
- W2018683003 countsByYear W20186830032023 @default.
- W2018683003 crossrefType "journal-article" @default.
- W2018683003 hasAuthorship W2018683003A5004736114 @default.
- W2018683003 hasAuthorship W2018683003A5011018903 @default.
- W2018683003 hasAuthorship W2018683003A5024586091 @default.
- W2018683003 hasAuthorship W2018683003A5053827994 @default.
- W2018683003 hasAuthorship W2018683003A5056823565 @default.
- W2018683003 hasAuthorship W2018683003A5058024376 @default.
- W2018683003 hasAuthorship W2018683003A5065948214 @default.
- W2018683003 hasAuthorship W2018683003A5066707974 @default.
- W2018683003 hasAuthorship W2018683003A5075076266 @default.
- W2018683003 hasAuthorship W2018683003A5077881176 @default.
- W2018683003 hasAuthorship W2018683003A5081375937 @default.
- W2018683003 hasAuthorship W2018683003A5091615720 @default.
- W2018683003 hasConcept C104317684 @default.
- W2018683003 hasConcept C134018914 @default.
- W2018683003 hasConcept C207200792 @default.
- W2018683003 hasConcept C2777488582 @default.
- W2018683003 hasConcept C2778106681 @default.
- W2018683003 hasConcept C2779959927 @default.
- W2018683003 hasConcept C2909166674 @default.
- W2018683003 hasConcept C3763915 @default.
- W2018683003 hasConcept C54355233 @default.