Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018685909> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2018685909 endingPage "S151" @default.
- W2018685909 startingPage "S151" @default.
- W2018685909 abstract "GTP and Ca2+, two well-known modulators of intracellular signaling pathways, control a structural/functional switch between two vital and mutually exclusive activities, cross-linking and Gαactivity, in the same enzyme. The enzyme, a brain-derived tissue-type transglutaminase (TGase), was recently cloned by us in two forms, one of which (s-TGN) lacks a C-terminal region that is present in the other (l-TGN). Immunoreaction with antibodies directed against a peptide present in the C-terminus of l-TGN but missing in s-TGN suggested that this site, which is located in the C-terminal fourth domain, undergoes conformational changes as a result of interaction between l-TGN and GTP. Site-directed mutagenesis suggested that the third domain is involved in mediating the inhibition of the cross-linking activity. These results were supported by molecular modeling, which further suggested that domains III and IV both participate in conformational changes leading to the functional switch between the Ca2+-dependent cross-linking activity and the Gαactivity." @default.
- W2018685909 created "2016-06-24" @default.
- W2018685909 creator A5002191815 @default.
- W2018685909 creator A5012640343 @default.
- W2018685909 creator A5047203156 @default.
- W2018685909 creator A5069092257 @default.
- W2018685909 creator A5070396950 @default.
- W2018685909 creator A5082141287 @default.
- W2018685909 creator A5089573057 @default.
- W2018685909 date "2007-01-01" @default.
- W2018685909 modified "2023-09-27" @default.
- W2018685909 title "Treatment with a Fullerene Derivative (ABS-75) Reduces Disease Progression and Axonal Loss in MOG-induced Progressive EAE in NOD Mice" @default.
- W2018685909 doi "https://doi.org/10.1016/j.clim.2007.03.069" @default.
- W2018685909 hasPublicationYear "2007" @default.
- W2018685909 type Work @default.
- W2018685909 sameAs 2018685909 @default.
- W2018685909 citedByCount "0" @default.
- W2018685909 crossrefType "journal-article" @default.
- W2018685909 hasAuthorship W2018685909A5002191815 @default.
- W2018685909 hasAuthorship W2018685909A5012640343 @default.
- W2018685909 hasAuthorship W2018685909A5047203156 @default.
- W2018685909 hasAuthorship W2018685909A5069092257 @default.
- W2018685909 hasAuthorship W2018685909A5070396950 @default.
- W2018685909 hasAuthorship W2018685909A5082141287 @default.
- W2018685909 hasAuthorship W2018685909A5089573057 @default.
- W2018685909 hasConcept C103408237 @default.
- W2018685909 hasConcept C104317684 @default.
- W2018685909 hasConcept C118716 @default.
- W2018685909 hasConcept C143065580 @default.
- W2018685909 hasConcept C16318435 @default.
- W2018685909 hasConcept C178498320 @default.
- W2018685909 hasConcept C178790620 @default.
- W2018685909 hasConcept C181199279 @default.
- W2018685909 hasConcept C185592680 @default.
- W2018685909 hasConcept C32123652 @default.
- W2018685909 hasConcept C32909587 @default.
- W2018685909 hasConcept C501734568 @default.
- W2018685909 hasConcept C515207424 @default.
- W2018685909 hasConcept C55493867 @default.
- W2018685909 hasConcept C57711820 @default.
- W2018685909 hasConcept C79879829 @default.
- W2018685909 hasConcept C86803240 @default.
- W2018685909 hasConcept C95444343 @default.
- W2018685909 hasConceptScore W2018685909C103408237 @default.
- W2018685909 hasConceptScore W2018685909C104317684 @default.
- W2018685909 hasConceptScore W2018685909C118716 @default.
- W2018685909 hasConceptScore W2018685909C143065580 @default.
- W2018685909 hasConceptScore W2018685909C16318435 @default.
- W2018685909 hasConceptScore W2018685909C178498320 @default.
- W2018685909 hasConceptScore W2018685909C178790620 @default.
- W2018685909 hasConceptScore W2018685909C181199279 @default.
- W2018685909 hasConceptScore W2018685909C185592680 @default.
- W2018685909 hasConceptScore W2018685909C32123652 @default.
- W2018685909 hasConceptScore W2018685909C32909587 @default.
- W2018685909 hasConceptScore W2018685909C501734568 @default.
- W2018685909 hasConceptScore W2018685909C515207424 @default.
- W2018685909 hasConceptScore W2018685909C55493867 @default.
- W2018685909 hasConceptScore W2018685909C57711820 @default.
- W2018685909 hasConceptScore W2018685909C79879829 @default.
- W2018685909 hasConceptScore W2018685909C86803240 @default.
- W2018685909 hasConceptScore W2018685909C95444343 @default.
- W2018685909 hasLocation W20186859091 @default.
- W2018685909 hasOpenAccess W2018685909 @default.
- W2018685909 hasPrimaryLocation W20186859091 @default.
- W2018685909 hasRelatedWork W1526675429 @default.
- W2018685909 hasRelatedWork W1969664130 @default.
- W2018685909 hasRelatedWork W1971735296 @default.
- W2018685909 hasRelatedWork W1981715774 @default.
- W2018685909 hasRelatedWork W2019340689 @default.
- W2018685909 hasRelatedWork W2039213678 @default.
- W2018685909 hasRelatedWork W2053583806 @default.
- W2018685909 hasRelatedWork W2102431124 @default.
- W2018685909 hasRelatedWork W2792698313 @default.
- W2018685909 hasRelatedWork W2184681542 @default.
- W2018685909 hasVolume "123" @default.
- W2018685909 isParatext "false" @default.
- W2018685909 isRetracted "false" @default.
- W2018685909 magId "2018685909" @default.
- W2018685909 workType "article" @default.