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- W2018688544 abstract "Dihydroxycoprostane and trihydroxycoprostane, intermediates in normal bile acid synthesis in the liver, enhanced the rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinate synthetase, the rate-limiting enzyme for this pathway. Other 5beta-cholestane derivatives and cholest-5-ene derivatives were ineffective. The selectivity of the induction may indicate that the above-mentioned coprostanes have a physiological role in porphyrin synthesis." @default.
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- W2018688544 date "1973-11-23" @default.
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- W2018688544 title "Porphyrin-Heme Pathway: Regulation by Intermediates in Bile Acid Synthesis" @default.
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- W2018688544 doi "https://doi.org/10.1126/science.182.4114.841" @default.
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