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- W2018690209 abstract "Abstract Background & Aims The long‐term clinical outcomes in initial survivors with acute liver failure ( ALF ) are not well known. The aim of this study was to provide an overview of the 2‐year clinical outcomes among initial survivors and liver transplant ( LT ) recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group ( ALFSG ). Methods Outcomes in adult ALFSG patients that were enrolled between 1998 and 2010 were reviewed. Results Two‐year patient survival was significantly higher in the 262 LT recipients (92.4%) compared to the 306 acetaminophen ( APAP ) spontaneous survivors ( SS ) (89.5%) and 200 non‐ APAP SS (75.5%) ( P < 0.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the LT recipients ( P < 0.0001). Independent predictors of 2‐year mortality in the APAP group were a high serum phosphate level and patient age (c‐statistic = 0.65 (0.54, 0.76)), patient age and days from jaundice to ALF onset in the non‐ APAP group (c‐statistic = 0.69 (0.60, 0.78)), and patient age, days from jaundice, and higher coma grade in the LT recipients (c‐statistic = 0.74 (0.61, 0.87)). The LT recipients were significantly more likely to be employed and have a higher educational level ( P < 0.05). Conclusions Two‐year outcomes in initial survivors of ALF are generally good but non‐ APAP patients have a significantly lower survival which may relate to pre‐existing medical comorbidities. Spontaneous survivors with APAP overdose experience substantial morbidity during follow‐up from ongoing psychiatric and substance abuse issues." @default.
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- W2018690209 date "2014-07-28" @default.
- W2018690209 modified "2023-10-15" @default.
- W2018690209 title "Two‐year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study" @default.
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- W2018690209 doi "https://doi.org/10.1111/liv.12632" @default.
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