FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018690457> ?p ?o ?g. }

• W2018690457 endingPage "e54452" @default.
• W2018690457 startingPage "e54452" @default.
• W2018690457 abstract "A strategy for antiviral drug discovery is the elucidation and imitation of viral interference mechanisms. HIV-1 patients benefit from a coinfection with GB Virus C (GBV-C), since HIV-positive individuals with long-term GBV-C viraemia show better survival rates than HIV-1 patients without persisting GBV-C. A direct influence of GBV-C on HIV-1 replication has been shown in coinfection experiments. GBV-C is a human non-pathogenic member of the flaviviridae family that can replicate in T and B cells. Therefore, GBV-C shares partly the same ecological niche with HIV-1. In earlier work we have demonstrated that recombinant glycoprotein E2 of GBV-C and peptides derived from the E2 N-terminus interfere with HIV entry. In this study we investigated the underlying mechanism. Performing a virus-cell fusion assay and temperature-arrested HIV-infection kinetics, we provide evidence that the HIV-inhibitory E2 peptides interfere with late HIV-1 entry steps after the engagement of gp120 with CD4 receptor and coreceptor. Binding and competition experiments revealed that the N-terminal E2 peptides bind to the disulfide loop region of HIV-1 transmembrane protein gp41. In conjunction with computational analyses, we identified sequence similarities between the N-termini of GBV-C E2 and the HIV-1 glycoprotein gp120. This similarity appears to enable the GBV-C E2 N-terminus to interact with the HIV-1 gp41 disulfide loop, a crucial domain involved in the gp120-gp41 interface. Furthermore, the results of the present study provide initial proof of concept that peptides targeted to the gp41 disulfide loop are able to inhibit HIV fusion and should inspire the development of this new class of HIV-1 entry inhibitors." @default.
• W2018690457 created "2016-06-24" @default.
• W2018690457 creator A5013034227 @default.
• W2018690457 creator A5038868099 @default.
• W2018690457 creator A5043855766 @default.
• W2018690457 creator A5056764808 @default.
• W2018690457 creator A5061260654 @default.
• W2018690457 creator A5065393453 @default.
• W2018690457 creator A5069302796 @default.
• W2018690457 creator A5077628487 @default.
• W2018690457 creator A5088639345 @default.
• W2018690457 creator A5088784630 @default.
• W2018690457 date "2013-01-22" @default.
• W2018690457 modified "2023-09-23" @default.
• W2018690457 title "HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop" @default.
• W2018690457 cites W1490369813 @default.
• W2018690457 cites W1895363198 @default.
• W2018690457 cites W1909984710 @default.
• W2018690457 cites W1963636589 @default.
• W2018690457 cites W1971057735 @default.
• W2018690457 cites W1980096897 @default.
• W2018690457 cites W1989035987 @default.
• W2018690457 cites W1991423866 @default.
• W2018690457 cites W1994930517 @default.
• W2018690457 cites W1996183144 @default.
• W2018690457 cites W1998885242 @default.
• W2018690457 cites W2005001815 @default.
• W2018690457 cites W2005155558 @default.
• W2018690457 cites W2005966087 @default.
• W2018690457 cites W2007376111 @default.
• W2018690457 cites W2008046418 @default.
• W2018690457 cites W2014733693 @default.
• W2018690457 cites W2016868458 @default.
• W2018690457 cites W2025005245 @default.
• W2018690457 cites W2026361605 @default.
• W2018690457 cites W2026899492 @default.
• W2018690457 cites W2027539258 @default.
• W2018690457 cites W2028446620 @default.
• W2018690457 cites W2029041011 @default.
• W2018690457 cites W2029379203 @default.
• W2018690457 cites W2036656105 @default.
• W2018690457 cites W2038063067 @default.
• W2018690457 cites W2043448829 @default.
• W2018690457 cites W2048336729 @default.
• W2018690457 cites W2053871841 @default.
• W2018690457 cites W2055193239 @default.
• W2018690457 cites W2059372215 @default.
• W2018690457 cites W2061894319 @default.
• W2018690457 cites W2063701397 @default.
• W2018690457 cites W2071297459 @default.
• W2018690457 cites W2075599499 @default.
• W2018690457 cites W2077684127 @default.
• W2018690457 cites W2082091832 @default.
• W2018690457 cites W2082261902 @default.
• W2018690457 cites W2083266836 @default.
• W2018690457 cites W2088292151 @default.
• W2018690457 cites W2088750194 @default.
• W2018690457 cites W2091254570 @default.
• W2018690457 cites W2092841704 @default.
• W2018690457 cites W2092875073 @default.
• W2018690457 cites W2094778792 @default.
• W2018690457 cites W2098265428 @default.
• W2018690457 cites W2098726090 @default.
• W2018690457 cites W2115235273 @default.
• W2018690457 cites W2120888945 @default.
• W2018690457 cites W2122798331 @default.
• W2018690457 cites W2123763815 @default.
• W2018690457 cites W2124296164 @default.
• W2018690457 cites W2129274180 @default.
• W2018690457 cites W2129478007 @default.
• W2018690457 cites W2130954786 @default.
• W2018690457 cites W2131317050 @default.
• W2018690457 cites W2134592415 @default.
• W2018690457 cites W2137978726 @default.
• W2018690457 cites W2140478082 @default.
• W2018690457 cites W2140900654 @default.
• W2018690457 cites W2141783940 @default.
• W2018690457 cites W2148349359 @default.
• W2018690457 cites W2151111558 @default.
• W2018690457 cites W2153543831 @default.
• W2018690457 cites W2160785432 @default.
• W2018690457 cites W2161836193 @default.
• W2018690457 cites W2165429311 @default.
• W2018690457 cites W2168357995 @default.
• W2018690457 cites W2169236651 @default.
• W2018690457 cites W2170710372 @default.
• W2018690457 cites W2297498980 @default.
• W2018690457 cites W2315848849 @default.
• W2018690457 cites W4237410627 @default.
• W2018690457 doi "https://doi.org/10.1371/journal.pone.0054452" @default.
• W2018690457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3551756" @default.
• W2018690457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349893" @default.
• W2018690457 hasPublicationYear "2013" @default.
• W2018690457 type Work @default.
• W2018690457 sameAs 2018690457 @default.
• W2018690457 citedByCount "18" @default.
• W2018690457 countsByYear W20186904572014 @default.
• W2018690457 countsByYear W20186904572015 @default.

• next