FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018691246> ?p ?o ?g. }

• W2018691246 endingPage "e41460" @default.
• W2018691246 startingPage "e41460" @default.
• W2018691246 abstract "Signaling by Bone Morphogenetic Proteins (BMP) has been implicated in early lung development, adult lung homeostasis and tissue-injury repair. However, the precise mechanism of action and the spatio-temporal pattern of BMP-signaling during these processes remains inadequately described. To address this, we have utilized a transgenic line harboring a BMP-responsive eGFP-reporter allele (BRE-eGFP) to construct the first detailed spatiotemporal map of canonical BMP-pathway activation during lung development, homeostasis and adult-lung injury repair. We demonstrate that during the pseudoglandular stage, when branching morphogenesis progresses in the developing lung, canonical BMP-pathway is active mainly in the vascular network and the sub-epithelial smooth muscle layer of the proximal airways. Activation of the BMP-pathway becomes evident in epithelial compartments only after embryonic day (E) 14.5 primarily in cells negative for epithelial-lineage markers, located in the proximal portion of the airway-tree, clusters adjacent to neuro-epithelial-bodies (NEBs) and in a substantial portion of alveolar epithelial cells. The pathway becomes activated in isolated E12.5 mesenchyme-free distal epithelial buds cultured in Matrigel suggesting that absence of reporter activity in these regions stems from a dynamic cross-talk between endoderm and mesenchyme. Epithelial cells with activated BMP-pathway are enriched in progenitors capable of forming colonies in three-dimensional Matrigel cultures.As lung morphogenesis approaches completion, eGFP-expression declines and in adult lung its expression is barely detectable. However, upon tissue-injury, either with naphthalene or bleomycin, the canonical BMP-pathways is re-activated, in bronchial or alveolar epithelial cells respectively, in a manner reminiscent to early lung development and in tissue areas where reparatory progenitor cells reside. Our studies illustrate the dynamic activation of canonical BMP-pathway during lung development and adult lung tissue-repair and highlight its involvement in two important processes, namely, the early development of the pulmonary vasculature and the management of epithelial progenitor pools both during lung development and repair of adult lung tissue-injury." @default.
• W2018691246 created "2016-06-24" @default.
• W2018691246 creator A5006746843 @default.
• W2018691246 creator A5008592883 @default.
• W2018691246 creator A5013582491 @default.
• W2018691246 creator A5023293666 @default.
• W2018691246 creator A5035855773 @default.
• W2018691246 creator A5052962413 @default.
• W2018691246 creator A5062224123 @default.
• W2018691246 creator A5068869985 @default.
• W2018691246 creator A5076380731 @default.
• W2018691246 creator A5084286346 @default.
• W2018691246 creator A5085628953 @default.
• W2018691246 date "2012-08-20" @default.
• W2018691246 modified "2023-09-30" @default.
• W2018691246 title "Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair" @default.
• W2018691246 cites W1587087111 @default.
• W2018691246 cites W1606814949 @default.
• W2018691246 cites W1843560668 @default.
• W2018691246 cites W1963272169 @default.
• W2018691246 cites W1963750365 @default.
• W2018691246 cites W1974046709 @default.
• W2018691246 cites W1976213734 @default.
• W2018691246 cites W1976397516 @default.
• W2018691246 cites W1979091346 @default.
• W2018691246 cites W1980989951 @default.
• W2018691246 cites W1987724354 @default.
• W2018691246 cites W1990124144 @default.
• W2018691246 cites W1991156103 @default.
• W2018691246 cites W1992949513 @default.
• W2018691246 cites W1995620639 @default.
• W2018691246 cites W1997111185 @default.
• W2018691246 cites W1997948433 @default.
• W2018691246 cites W2001508112 @default.
• W2018691246 cites W2007610579 @default.
• W2018691246 cites W2012213575 @default.
• W2018691246 cites W2013575704 @default.
• W2018691246 cites W2024925152 @default.
• W2018691246 cites W2032918836 @default.
• W2018691246 cites W2042250615 @default.
• W2018691246 cites W2044585013 @default.
• W2018691246 cites W2048390041 @default.
• W2018691246 cites W2052316245 @default.
• W2018691246 cites W2053239277 @default.
• W2018691246 cites W2057700884 @default.
• W2018691246 cites W2065839331 @default.
• W2018691246 cites W2066198185 @default.
• W2018691246 cites W2071596110 @default.
• W2018691246 cites W2076044667 @default.
• W2018691246 cites W2076381257 @default.
• W2018691246 cites W2079666001 @default.
• W2018691246 cites W2080198224 @default.
• W2018691246 cites W2088465910 @default.
• W2018691246 cites W2089816526 @default.
• W2018691246 cites W2093271566 @default.
• W2018691246 cites W2096566481 @default.
• W2018691246 cites W2105902643 @default.
• W2018691246 cites W2107277218 @default.
• W2018691246 cites W2110042849 @default.
• W2018691246 cites W2112903125 @default.
• W2018691246 cites W2119835285 @default.
• W2018691246 cites W2121672537 @default.
• W2018691246 cites W2123921311 @default.
• W2018691246 cites W2126684945 @default.
• W2018691246 cites W2128603782 @default.
• W2018691246 cites W2130752844 @default.
• W2018691246 cites W2140082916 @default.
• W2018691246 cites W2141020926 @default.
• W2018691246 cites W2141317338 @default.
• W2018691246 cites W2142177295 @default.
• W2018691246 cites W2142325605 @default.
• W2018691246 cites W2143665658 @default.
• W2018691246 cites W2146701605 @default.
• W2018691246 cites W2152237832 @default.
• W2018691246 cites W2154294808 @default.
• W2018691246 cites W2154568166 @default.
• W2018691246 cites W2158958245 @default.
• W2018691246 cites W2159545748 @default.
• W2018691246 cites W2159836397 @default.
• W2018691246 cites W2161357967 @default.
• W2018691246 cites W2161616183 @default.
• W2018691246 cites W2164101293 @default.
• W2018691246 cites W2747915831 @default.
• W2018691246 cites W50406751 @default.
• W2018691246 cites W47838661 @default.
• W2018691246 doi "https://doi.org/10.1371/journal.pone.0041460" @default.
• W2018691246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3423416" @default.
• W2018691246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22916109" @default.
• W2018691246 hasPublicationYear "2012" @default.
• W2018691246 type Work @default.
• W2018691246 sameAs 2018691246 @default.
• W2018691246 citedByCount "54" @default.
• W2018691246 countsByYear W20186912462013 @default.
• W2018691246 countsByYear W20186912462014 @default.
• W2018691246 countsByYear W20186912462015 @default.
• W2018691246 countsByYear W20186912462016 @default.
• W2018691246 countsByYear W20186912462017 @default.
• W2018691246 countsByYear W20186912462018 @default.

• next