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- W2018691261 abstract "Sesquiterpene lactones, natural constitutents of the Asteraceae, are toxic to the grasshopper, Melanoplus sanguinipes, when injected into the hemocoel at doses greater than 0.25 μmol/300 mg insect. Dose-dependent sublethal symptoms range from a slight reduction in normal locomotory ability to severe locomotory impairment or paralysis, leading to death. The symptoms appear to be irreversible. Of the four compounds subjected to dose-response testing, parthenin was the most toxic with and LD50 in adult male grasshoppers of 0.55 μmol/insect. Structure-activity relationships for four of the six lactones tested indicate that compounds containing a cyclopentenone ring are equitoxic to males and females, whereas those lacking this functional group are approximately 4 × more toxic to males than females. In contrast to their sensitivity to injected lactones, adult male grasshoppers can tolerate ingestion or topical administration of up to 4 μmol of these compounds without any adverse effects. These results suggest that the integument and alimentary canal in this species provide effective barriers limiting the bioavailability of sesquiterpene lactones to the hemolymph in nature. Possible target sites and mechanisms-of-action for sesquiterpene lactones (once in the bloodstream) are discussed." @default.
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- W2018691261 title "Toxicity and tolerance of sesquiterpene lactones in the migratory grasshopper, Melanoplus sanguinipes (Acrididae)" @default.
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- W2018691261 doi "https://doi.org/10.1016/0048-3575(85)90146-4" @default.
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